FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124307002> ?p ?o ?g. }

• W3124307002 endingPage "846" @default.
• W3124307002 startingPage "835" @default.
• W3124307002 abstract "Primary biliary cholangitis (PBC) is a prototypical organ-specific autoimmune disease that is mediated by autoreactive T-cell attack and destruction of cholangiocytes. Despite the clear role of autoimmunity in PBC, immune-directed therapies have failed to halt PBC, including biologic therapies effective in other autoimmune diseases. MicroRNA (miRNA) dysregulation is implicated in the pathogenesis (PBC). In the dominant-negative TGF-β receptor type II (dnTGFβRII) mouse model of PBC, autoreactive CD8 T cells play a major pathogenic role and demonstrate a striking pattern of miRNA down-regulation. Enoxacin is a small molecule fluoroquinolone that enhances miRNA biogenesis, partly by stabilizing the interaction of transactivation response RNA-binding protein with Argonaute (Ago) 2.We hypothesized that correcting aberrant T-cell miRNA expression with enoxacin in dnTGFβRII mice could modulate autoreactive T-cell function and prevent PBC. Here, we show that liver-infiltrating dnTGFβRII CD8 T cells have significantly decreased levels of the miRNA biogenesis molecules prolyl 4-hydroxylase subunit alpha 1 (P4HA1) and Ago2 along with significantly increased levels of granzyme B and perforin. Enoxacin treatment significantly up-regulated miRNAs in dnTGFβRII CD8 T cells and effectively treated autoimmune cholangitis in dnTGFβRII mice. Enoxacin treatment directly altered T cells both ex vivo and in vitro, resulting in altered memory subset numbers, decreased proliferation, and decreased interferon-γ production. Enoxacin significantly decreased CD8 T-cell expression of the transcription factor, Runx3, and significantly decreased perforin expression at both the mRNA and protein levels.Enoxacin increases miRNA expression in dnTGFβRII CD8 T cells, reduces CD8 T-cell pathogenicity, and effectively halted progression of autoimmune biliary disease. Targeting the miRNA pathway is a therapeutic approach to autoimmunity that corrects pathological miRNA abnormalities in autoreactive T cells." @default.
• W3124307002 created "2021-02-01" @default.
• W3124307002 creator A5000573586 @default.
• W3124307002 creator A5016645912 @default.
• W3124307002 creator A5022981941 @default.
• W3124307002 creator A5025186777 @default.
• W3124307002 creator A5026873284 @default.
• W3124307002 creator A5029678899 @default.
• W3124307002 creator A5041755596 @default.
• W3124307002 creator A5053663550 @default.
• W3124307002 creator A5057344751 @default.
• W3124307002 creator A5064443404 @default.
• W3124307002 creator A5066462726 @default.
• W3124307002 date "2021-08-01" @default.
• W3124307002 modified "2023-10-18" @default.
• W3124307002 title "Enoxacin Up‐Regulates MicroRNA Biogenesis and Down‐Regulates Cytotoxic CD8 T‐Cell Function in Autoimmune Cholangitis" @default.
• W3124307002 cites W1649262326 @default.
• W3124307002 cites W1650215555 @default.
• W3124307002 cites W1759915812 @default.
• W3124307002 cites W1941480039 @default.
• W3124307002 cites W1987265108 @default.
• W3124307002 cites W1999771079 @default.
• W3124307002 cites W2005075246 @default.
• W3124307002 cites W2006268101 @default.
• W3124307002 cites W2009341609 @default.
• W3124307002 cites W2018134941 @default.
• W3124307002 cites W2018693913 @default.
• W3124307002 cites W2020940277 @default.
• W3124307002 cites W2034563022 @default.
• W3124307002 cites W2043644749 @default.
• W3124307002 cites W2047628040 @default.
• W3124307002 cites W2049907435 @default.
• W3124307002 cites W2064792413 @default.
• W3124307002 cites W2071282345 @default.
• W3124307002 cites W2082678538 @default.
• W3124307002 cites W2082997857 @default.
• W3124307002 cites W2087972419 @default.
• W3124307002 cites W2092989362 @default.
• W3124307002 cites W2095905881 @default.
• W3124307002 cites W2099293835 @default.
• W3124307002 cites W2099774208 @default.
• W3124307002 cites W2101443221 @default.
• W3124307002 cites W2101543035 @default.
• W3124307002 cites W2103005112 @default.
• W3124307002 cites W2107101690 @default.
• W3124307002 cites W2113209482 @default.
• W3124307002 cites W2130000937 @default.
• W3124307002 cites W2137135650 @default.
• W3124307002 cites W2143657331 @default.
• W3124307002 cites W2159998849 @default.
• W3124307002 cites W2162599367 @default.
• W3124307002 cites W2167441884 @default.
• W3124307002 cites W2251277318 @default.
• W3124307002 cites W2295821227 @default.
• W3124307002 cites W2389330309 @default.
• W3124307002 cites W2562330267 @default.
• W3124307002 cites W2576456099 @default.
• W3124307002 cites W2587742079 @default.
• W3124307002 cites W2588845501 @default.
• W3124307002 cites W2803659521 @default.
• W3124307002 cites W2940912914 @default.
• W3124307002 cites W2974278736 @default.
• W3124307002 cites W4292540530 @default.
• W3124307002 doi "https://doi.org/10.1002/hep.31724" @default.
• W3124307002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33462854" @default.
• W3124307002 hasPublicationYear "2021" @default.
• W3124307002 type Work @default.
• W3124307002 sameAs 3124307002 @default.
• W3124307002 citedByCount "8" @default.
• W3124307002 countsByYear W31243070022022 @default.
• W3124307002 crossrefType "journal-article" @default.
• W3124307002 hasAuthorship W3124307002A5000573586 @default.
• W3124307002 hasAuthorship W3124307002A5016645912 @default.
• W3124307002 hasAuthorship W3124307002A5022981941 @default.
• W3124307002 hasAuthorship W3124307002A5025186777 @default.
• W3124307002 hasAuthorship W3124307002A5026873284 @default.
• W3124307002 hasAuthorship W3124307002A5029678899 @default.
• W3124307002 hasAuthorship W3124307002A5041755596 @default.
• W3124307002 hasAuthorship W3124307002A5053663550 @default.
• W3124307002 hasAuthorship W3124307002A5057344751 @default.
• W3124307002 hasAuthorship W3124307002A5064443404 @default.
• W3124307002 hasAuthorship W3124307002A5066462726 @default.
• W3124307002 hasBestOaLocation W31243070021 @default.
• W3124307002 hasConcept C154317977 @default.
• W3124307002 hasConcept C167672396 @default.
• W3124307002 hasConcept C202751555 @default.
• W3124307002 hasConcept C203014093 @default.
• W3124307002 hasConcept C2776062744 @default.
• W3124307002 hasConcept C2776072828 @default.
• W3124307002 hasConcept C2776090121 @default.
• W3124307002 hasConcept C2778512257 @default.
• W3124307002 hasConcept C2778746504 @default.
• W3124307002 hasConcept C2780380082 @default.
• W3124307002 hasConcept C502942594 @default.
• W3124307002 hasConcept C523546767 @default.
• W3124307002 hasConcept C54355233 @default.
• W3124307002 hasConcept C55493867 @default.
• W3124307002 hasConcept C86803240 @default.

• next