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• W3124324712 abstract "Hyperlipidemia can easily cause atherosclerosis and induce cardiovascular and cerebrovascular diseases. Red yeast rice (RYR) contains a variety of active ingredients and is commonly used as medicine and food, and has pharmacological effects such as lowering blood lipids. In this study, we select Monascus strain SHM1105 with a high yield of Monacolin K and monascus pigment (PIG), and studied the effects of the RYR and PIG fermented by this strain on blood lipids, intestinal flora, and liver transcriptome in hyperlipidemia model rats. The experimental results show that, compared with the high-fat model group, the weight growth rate, liver weight ratio, kidney weight ratio, spleen weight ratio, and fat weight ratio of rats in the gavage lovastatin (LOV), RYR, and PIG group were all significantly decreased ( p &lt; 0.05). Intervention with RYR and PIG can significantly reduce the serum TC, TG, and LDL-C levels, which has the effect of lowering blood lipids. The 16SrDNA sequencing results showed that the ratio of Firmicutes/Bacteroidetes decreased significantly ( p ≤ 0.01) after the intervention of LOV, RYR, and PIG; the abundance of the ratio of Lachnospiraceae , Ruminococcaceae , Prevotellaceae , and Bacteroidales-S24-7-group also changed. The combined analysis of transcriptome and metabolome showed that lovastatin, RYR, and PIG can all improve lipid metabolism in rats by regulating Steroid hormone biosynthesis, Glycerolipid metabolism, and the Arachidonic acid metabolism pathway. In addition, RYR and PIG also have a unique way of regulating blood lipids. Although a lot of research on the lipid-lowering components of Monascus rice and the single pigment component of Monascus has been carried out, the actual application is RYR and pigments as mixtures, as a mixture of RYR and PIG contains a variety of biologically active ingredients, and each component may have a synergistic effect. Hence it has a lipid-lowering mechanism that lovastatin does not have. Therefore, RYR and PIG are effective in reducing lipid potential development and can be utilized in functional foods." @default.
• W3124324712 created "2021-02-01" @default.
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• W3124324712 date "2021-01-21" @default.
• W3124324712 modified "2023-10-02" @default.
• W3124324712 title "Modulation of the Gut Microbiota and Liver Transcriptome by Red Yeast Rice and Monascus Pigment Fermented by Purple Monascus SHM1105 in Rats Fed with a High-Fat Diet" @default.
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• W3124324712 cites W1714765228 @default.
• W3124324712 cites W1745058254 @default.
• W3124324712 cites W1966922165 @default.
• W3124324712 cites W1968105193 @default.
• W3124324712 cites W1993169389 @default.
• W3124324712 cites W1997240104 @default.
• W3124324712 cites W1999574084 @default.
• W3124324712 cites W2000984739 @default.
• W3124324712 cites W2001889721 @default.
• W3124324712 cites W2006404454 @default.
• W3124324712 cites W2017818975 @default.
• W3124324712 cites W2020867225 @default.
• W3124324712 cites W2031355202 @default.
• W3124324712 cites W2045708560 @default.
• W3124324712 cites W2051315228 @default.
• W3124324712 cites W2057135977 @default.
• W3124324712 cites W2074005494 @default.
• W3124324712 cites W2087795243 @default.
• W3124324712 cites W2110389012 @default.
• W3124324712 cites W2111699021 @default.
• W3124324712 cites W2115801316 @default.
• W3124324712 cites W2128705098 @default.
• W3124324712 cites W2151714890 @default.
• W3124324712 cites W2165417071 @default.
• W3124324712 cites W2168287213 @default.
• W3124324712 cites W2206854629 @default.
• W3124324712 cites W2214388745 @default.
• W3124324712 cites W2258370467 @default.
• W3124324712 cites W2317122257 @default.
• W3124324712 cites W2334748203 @default.
• W3124324712 cites W2345752308 @default.
• W3124324712 cites W2409620799 @default.
• W3124324712 cites W2409656339 @default.
• W3124324712 cites W2413004278 @default.
• W3124324712 cites W2441277973 @default.
• W3124324712 cites W2473313158 @default.
• W3124324712 cites W2477547149 @default.
• W3124324712 cites W2495627383 @default.
• W3124324712 cites W2508828471 @default.
• W3124324712 cites W2509121705 @default.
• W3124324712 cites W2515285081 @default.
• W3124324712 cites W2600254651 @default.
• W3124324712 cites W2607843717 @default.
• W3124324712 cites W2620098478 @default.
• W3124324712 cites W2625861313 @default.
• W3124324712 cites W2734037486 @default.
• W3124324712 cites W2734372941 @default.
• W3124324712 cites W2743820880 @default.
• W3124324712 cites W2749437927 @default.
• W3124324712 cites W2773643620 @default.
• W3124324712 cites W2777658932 @default.
• W3124324712 cites W2781676045 @default.
• W3124324712 cites W2791492145 @default.
• W3124324712 cites W2791901121 @default.
• W3124324712 cites W2810309731 @default.
• W3124324712 cites W2898905022 @default.
• W3124324712 cites W2910147931 @default.
• W3124324712 cites W2911179086 @default.
• W3124324712 cites W2914075272 @default.
• W3124324712 cites W2914725672 @default.
• W3124324712 cites W2916965173 @default.
• W3124324712 cites W2949067868 @default.
• W3124324712 cites W2963560867 @default.
• W3124324712 cites W2972739903 @default.
• W3124324712 cites W2981499784 @default.
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• W3124324712 cites W2996037132 @default.
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• W3124324712 doi "https://doi.org/10.3389/fphar.2020.599760" @default.
• W3124324712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7859525" @default.
• W3124324712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33551805" @default.
• W3124324712 hasPublicationYear "2021" @default.
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