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- W3124326164 abstract "espanolObjetivos. El diagnostico correcto de la sepsis en urgencias es clave para iniciar el tratamiento de forma adecuada. Para ello, se han estudiado multiples biomarcadores que podrian ser de utilidad. El objetivo principal de este estudio fue evaluar la capacidad diagnostica de presepsina en sangre, en comparacion con procalcitonina (PCT), proteina C reactiva (PCR) y lactato, para predecir sepsis o shock septico segun la definicion de Sepsis-3. El objetivo secundario fue valorar la capacidad de estos biomarcadores para predecir bacteriemia, independientemente del diagnostico final de sepsis o shock septico. Metodo. Estudio prospectivo de cohorte observacional, realizado en un unico servicio de urgencias (SU) de un hospital universitario. Se incluyeron pacientes con sospecha clinica de infeccion y al menos dos criterios de sindrome de respuesta inflamatoria sistemica. En todos los pacientes se determino en sangre presepsina, PCT, PCR y lactato en el momento de la visita en el SU. Resultados. Se analizaron 359 pacientes, de los que 228 (63,5%) presentaban criterios de sepsis y 20 (5,6%) de shock septico. PCT y presepsina fueron los mejores biomarcadores para predecir la sepsis/shock septico con un area bajo la curva (ABC) de la capacidad operativa del receptor (ROC) de 0,711 (IC 95% 0,660-0,758; p Conclusion. La presepsina y la PCT son los biomarcadores con mejor rendimiento para el diagnostico de sepsis y shock septico en el SU. EnglishObjectives. An accurate diagnosis of sepsis in the emergency department must be made before appropriate treatment can be started. Many biomarkers that are potentially useful have been studied. The main aim of this study was to compare the diagnostic accuracy of blood levels of presepsin, lactate, C-reactive protein (CRP), and procalcitonin (PCT) for predicting sepsis as defined by the Sepsis-3 criteria. The secondary aim was to evaluate the diagnostic accuracy of these biomarkers for predicting bacteremia whether or not sepsis or septic shock was present. Methods. Single-center, prospective, observational cohort study in the emergency department of a university hospital. Consecutive patients suspected of having infection were enrolled prospectively if they had at least 2 criteria for systemic inflammatory response syndrome. We measured presepsin, PCT, CRP, and lactate in blood extracted on admission. Results. Blood samples from 359 patients were analyzed; 228 (63.5%) met the criteria for sepsis and 20 (5.6%) met the criteria for septic shock. PCT and presepsin levels were the best predictors of sepsis and septic shock with areas under the receiver operating characteristic curve (AUC) of 0.711 (95% CI, 0.660–0.758) and 0.709 (95% CI, 0.658– 0.756), respectively (P Conclusion. Presepsin and PCT seem to be the best predictors of a diagnosis of sepsis or septic shock in emergency department patients." @default.
- W3124326164 created "2021-02-01" @default.
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- W3124326164 date "2019-01-01" @default.
- W3124326164 modified "2023-09-27" @default.
- W3124326164 title "Capacidad diagnóstica de presepsina comparada con otros biomarcadores para predecir sepsis y shock séptico en pacientes con infección siguiendo la definición Sepsis-3 (estudio PREDI)" @default.
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