Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124360018> ?p ?o ?g. }
- W3124360018 abstract "DNA double-strand breaks (DSBs) are harmful to the cell as it could lead to genomic instability and cell death when left unrepaired. Homologous recombination and nonhomologous end-joining (NHEJ) are two major DSB repair pathways, responsible for ensuring genome integrity in mammals. There have been multiple efforts using small molecule inhibitors to target these DNA repair pathways in cancers. SCR7 is a very well-studied anticancer molecule that blocks NHEJ by targeting one of the critical enzymes, Ligase IV.In this review, we have highlighted the anticancer effects of SCR7 as a single agent and in combination with other chemotherapeutic agents and radiation. SCR7 blocked NHEJ effectively both in vitro and ex vivo. SCR7 has been used for biochemical studies like chromosomal territory resetting and in understanding the role of repair proteins in cell cycle phases. Various forms of SCR7 and its derivatives are discussed. SCR7 is also used as a potent biochemical inhibitor of NHEJ, which has found its application in improving genome editing using a CRISPR-Cas system.SCR7 is a potent NHEJ inhibitor with unique properties and wide applications as an anticancer agent. Most importantly, SCR7 has become a handy aid for improving genome editing across different model systems." @default.
- W3124360018 created "2021-02-01" @default.
- W3124360018 creator A5003508566 @default.
- W3124360018 creator A5010681275 @default.
- W3124360018 creator A5028589689 @default.
- W3124360018 date "2021-01-26" @default.
- W3124360018 modified "2023-10-18" @default.
- W3124360018 title "SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining" @default.
- W3124360018 cites W1603039152 @default.
- W3124360018 cites W1841331176 @default.
- W3124360018 cites W1906870688 @default.
- W3124360018 cites W1911522267 @default.
- W3124360018 cites W1973268287 @default.
- W3124360018 cites W1977314726 @default.
- W3124360018 cites W1979240756 @default.
- W3124360018 cites W1986947222 @default.
- W3124360018 cites W1997571629 @default.
- W3124360018 cites W1998605457 @default.
- W3124360018 cites W2008147758 @default.
- W3124360018 cites W2009007206 @default.
- W3124360018 cites W2015461126 @default.
- W3124360018 cites W2024101825 @default.
- W3124360018 cites W2045058134 @default.
- W3124360018 cites W2048250731 @default.
- W3124360018 cites W2055890925 @default.
- W3124360018 cites W2064194162 @default.
- W3124360018 cites W2069983649 @default.
- W3124360018 cites W2096261947 @default.
- W3124360018 cites W2102003117 @default.
- W3124360018 cites W2110565227 @default.
- W3124360018 cites W2111583990 @default.
- W3124360018 cites W2117094974 @default.
- W3124360018 cites W2131561597 @default.
- W3124360018 cites W2137602599 @default.
- W3124360018 cites W2147477441 @default.
- W3124360018 cites W2163248265 @default.
- W3124360018 cites W2164995160 @default.
- W3124360018 cites W2168493348 @default.
- W3124360018 cites W2281629727 @default.
- W3124360018 cites W2328913237 @default.
- W3124360018 cites W2468114878 @default.
- W3124360018 cites W2495749767 @default.
- W3124360018 cites W2560312390 @default.
- W3124360018 cites W2625686290 @default.
- W3124360018 cites W2734990550 @default.
- W3124360018 cites W2767210716 @default.
- W3124360018 cites W2792500887 @default.
- W3124360018 cites W2796986527 @default.
- W3124360018 cites W2804797444 @default.
- W3124360018 cites W2886132864 @default.
- W3124360018 cites W2889820084 @default.
- W3124360018 cites W2904077352 @default.
- W3124360018 cites W2945540316 @default.
- W3124360018 cites W2979285267 @default.
- W3124360018 cites W2991449575 @default.
- W3124360018 cites W3006063841 @default.
- W3124360018 cites W3010836932 @default.
- W3124360018 cites W3047763723 @default.
- W3124360018 cites W3048617515 @default.
- W3124360018 cites W3082458310 @default.
- W3124360018 doi "https://doi.org/10.1002/cnr2.1341" @default.
- W3124360018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8222562" @default.
- W3124360018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33496064" @default.
- W3124360018 hasPublicationYear "2021" @default.
- W3124360018 type Work @default.
- W3124360018 sameAs 3124360018 @default.
- W3124360018 citedByCount "6" @default.
- W3124360018 countsByYear W31243600182021 @default.
- W3124360018 countsByYear W31243600182022 @default.
- W3124360018 countsByYear W31243600182023 @default.
- W3124360018 crossrefType "journal-article" @default.
- W3124360018 hasAuthorship W3124360018A5003508566 @default.
- W3124360018 hasAuthorship W3124360018A5010681275 @default.
- W3124360018 hasAuthorship W3124360018A5028589689 @default.
- W3124360018 hasBestOaLocation W31243600181 @default.
- W3124360018 hasConcept C102744134 @default.
- W3124360018 hasConcept C104317684 @default.
- W3124360018 hasConcept C104451858 @default.
- W3124360018 hasConcept C121608353 @default.
- W3124360018 hasConcept C122917832 @default.
- W3124360018 hasConcept C134935766 @default.
- W3124360018 hasConcept C143425029 @default.
- W3124360018 hasConcept C144501496 @default.
- W3124360018 hasConcept C175114707 @default.
- W3124360018 hasConcept C178169997 @default.
- W3124360018 hasConcept C185592680 @default.
- W3124360018 hasConcept C54355233 @default.
- W3124360018 hasConcept C552990157 @default.
- W3124360018 hasConcept C70721500 @default.
- W3124360018 hasConcept C74054111 @default.
- W3124360018 hasConcept C86803240 @default.
- W3124360018 hasConcept C95444343 @default.
- W3124360018 hasConcept C96232424 @default.
- W3124360018 hasConcept C98108389 @default.
- W3124360018 hasConceptScore W3124360018C102744134 @default.
- W3124360018 hasConceptScore W3124360018C104317684 @default.
- W3124360018 hasConceptScore W3124360018C104451858 @default.
- W3124360018 hasConceptScore W3124360018C121608353 @default.
- W3124360018 hasConceptScore W3124360018C122917832 @default.
- W3124360018 hasConceptScore W3124360018C134935766 @default.