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- W3124391322 abstract "In long-term stress exposure, excess glucocorticoids disturb the balance of monoamine neurotransmitters leading to mood disorders and memory impairment. Venlafaxine and Agomelatin are currently used to treat these disorders. Voluntary exercise also has beneficial effects on mental health. In this work, we analyzed 1. the time-dependent changes in stress-induced mood disorders, 2. the modulating effect of voluntary exercise on the hypothalamic pituitary adrenal axis, 3. the effectiveness of Agomelatin, Venlafaxine and exercise to prevent stress-related behaviors and 4. the localization of MT1 and MT2 receptors in transgenic reporter mice. We demonstrate that stress caused physical, emotional and behavioral abnormalities in stressed rats. Pre-treatment with Agomelatin, Venlafaxine and exercise reduced the chronic stress-related behaviors and prevented anxiety, depression and memory deficits. The mapping of MT1 and MT2 receptors identified potential sites of action of Agomelatin." @default.
- W3124391322 created "2021-02-01" @default.
- W3124391322 creator A5036019617 @default.
- W3124391322 date "2017-06-07" @default.
- W3124391322 modified "2023-09-27" @default.
- W3124391322 title "Neuroprotective effects of voluntary exercise and monoaminergic modulators in stressed male rats" @default.
- W3124391322 hasPublicationYear "2017" @default.
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