Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124401574> ?p ?o ?g. }
- W3124401574 endingPage "386" @default.
- W3124401574 startingPage "386" @default.
- W3124401574 abstract "Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local recurrence remains high and is the major cause of death for patients with STS. A better understanding of cell fates in response to RT could provide new therapeutic options to enhance tumour cell killing by RT and facilitate surgical resection. Here, we showed that irradiated STS cell cultures do not die but instead undergo therapy-induced senescence (TIS), which is characterized by proliferation arrest, senescence-associated β-galactosidase activity, secretion of inflammatory cytokines and persistent DNA damage. STS-TIS was also associated with increased levels of the anti-apoptotic Bcl-2 family of proteins which rendered cells targetable using senolytic Bcl-2 inhibitors. As oppose to radiation alone, the addition of senolytic agents Venetoclax (ABT-199) or Navitoclax (ABT-263) after irradiation induced a rapid apoptotic cell death in STS monolayer cultures and in a more complex three-dimensional culture model. Together, these data suggest a new promising therapeutic approach for sarcoma patients who receive neoadjuvant RT. The addition of senolytic agents to radiation treatments may significantly reduce tumour volume prior to surgery and thereby improve the clinical outcome of patients." @default.
- W3124401574 created "2021-02-01" @default.
- W3124401574 creator A5004902119 @default.
- W3124401574 creator A5014358655 @default.
- W3124401574 creator A5036894393 @default.
- W3124401574 creator A5047080227 @default.
- W3124401574 creator A5049046475 @default.
- W3124401574 creator A5078309950 @default.
- W3124401574 date "2021-01-21" @default.
- W3124401574 modified "2023-10-13" @default.
- W3124401574 title "Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells" @default.
- W3124401574 cites W1790125969 @default.
- W3124401574 cites W1966955663 @default.
- W3124401574 cites W1970891016 @default.
- W3124401574 cites W1976197588 @default.
- W3124401574 cites W1980920506 @default.
- W3124401574 cites W1994474279 @default.
- W3124401574 cites W2010417927 @default.
- W3124401574 cites W2017343188 @default.
- W3124401574 cites W2026885876 @default.
- W3124401574 cites W2030795773 @default.
- W3124401574 cites W2034183402 @default.
- W3124401574 cites W2036291018 @default.
- W3124401574 cites W2044341880 @default.
- W3124401574 cites W2047741179 @default.
- W3124401574 cites W2051346698 @default.
- W3124401574 cites W2052566970 @default.
- W3124401574 cites W2053956988 @default.
- W3124401574 cites W2059416155 @default.
- W3124401574 cites W2061619522 @default.
- W3124401574 cites W2068567746 @default.
- W3124401574 cites W2068840787 @default.
- W3124401574 cites W2077814905 @default.
- W3124401574 cites W2078884678 @default.
- W3124401574 cites W2084484454 @default.
- W3124401574 cites W2085419794 @default.
- W3124401574 cites W2100457375 @default.
- W3124401574 cites W2102461774 @default.
- W3124401574 cites W2104908670 @default.
- W3124401574 cites W2108387330 @default.
- W3124401574 cites W2110525250 @default.
- W3124401574 cites W2116054786 @default.
- W3124401574 cites W2119316461 @default.
- W3124401574 cites W2120794369 @default.
- W3124401574 cites W2128807350 @default.
- W3124401574 cites W2131078803 @default.
- W3124401574 cites W2150680216 @default.
- W3124401574 cites W2153477869 @default.
- W3124401574 cites W2157411658 @default.
- W3124401574 cites W2162118018 @default.
- W3124401574 cites W2168632005 @default.
- W3124401574 cites W2170725518 @default.
- W3124401574 cites W2172242534 @default.
- W3124401574 cites W2175189903 @default.
- W3124401574 cites W2178124407 @default.
- W3124401574 cites W2192121806 @default.
- W3124401574 cites W2210634983 @default.
- W3124401574 cites W2224886002 @default.
- W3124401574 cites W2319232270 @default.
- W3124401574 cites W2342672703 @default.
- W3124401574 cites W2411937682 @default.
- W3124401574 cites W2504155943 @default.
- W3124401574 cites W2514200009 @default.
- W3124401574 cites W2534349779 @default.
- W3124401574 cites W2589060305 @default.
- W3124401574 cites W2591114726 @default.
- W3124401574 cites W2593208709 @default.
- W3124401574 cites W2620804057 @default.
- W3124401574 cites W2735901092 @default.
- W3124401574 cites W2765905079 @default.
- W3124401574 cites W2769935557 @default.
- W3124401574 cites W2774171294 @default.
- W3124401574 cites W2777786283 @default.
- W3124401574 cites W2788548733 @default.
- W3124401574 cites W2790056846 @default.
- W3124401574 cites W2892573863 @default.
- W3124401574 cites W2896878953 @default.
- W3124401574 cites W2900339571 @default.
- W3124401574 cites W2902257786 @default.
- W3124401574 cites W2903003302 @default.
- W3124401574 cites W2905070646 @default.
- W3124401574 cites W2912091820 @default.
- W3124401574 cites W2939228953 @default.
- W3124401574 cites W2942007182 @default.
- W3124401574 cites W2947567945 @default.
- W3124401574 cites W2947905501 @default.
- W3124401574 cites W2951114010 @default.
- W3124401574 cites W2962935165 @default.
- W3124401574 cites W2971405778 @default.
- W3124401574 cites W3009181538 @default.
- W3124401574 cites W3011410517 @default.
- W3124401574 cites W3015152600 @default.
- W3124401574 cites W3045938047 @default.
- W3124401574 cites W3104295652 @default.
- W3124401574 doi "https://doi.org/10.3390/cancers13030386" @default.
- W3124401574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7866159" @default.
- W3124401574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33494434" @default.
- W3124401574 hasPublicationYear "2021" @default.