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• W3124422910 abstract "Purpose of review Superficial vascular anomalies are a heterogeneous group of malformative and tumoral lesions, developed from various types of abnormal lymphatic and/or blood vessels. They are mostly benign but their clinical evolution can lead to dramatic cosmetic concern, functional impairment and even life-threatening conditions. Until recently, treatments relied on invasive procedures such as embotherapy/sclerotherapy and/or surgery. Recent molecular findings pave the way of new medical therapies. Recent findings Two main signaling pathways PI3K-AKT-mTOR and RAS-MAPK-ERK are now identified to encounter for the causative pathogenic genetic variants of most vascular anomalies. Involved genes are also responsible for several common neoplasms for which targeted therapies are already available or under development. Repurposing treatment strategy is considered for vascular anomalies treatment with promising results. Summary The mTOR inhibitor sirolimus is the most used targeted therapy so far but new molecules are tested currently." @default.
• W3124422910 created "2021-02-01" @default.
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• W3124422910 date "2021-01-19" @default.
• W3124422910 modified "2023-10-13" @default.
• W3124422910 title "Congenital vascular lesions, could MAPK and PI3K inhibitors pave the way to new therapies?" @default.
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• W3124422910 doi "https://doi.org/10.1097/cco.0000000000000712" @default.
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