FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124433332> ?p ?o ?g. }

• W3124433332 endingPage "1787" @default.
• W3124433332 startingPage "1779" @default.
• W3124433332 abstract "This work examines the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. Ibuprofen (pKa = 5.3) is in its anionic form, whereas paracetamol (pKa 9.4) is only partially ionized at the synthesis pH (9.0), and thus intercalation is expected to be different in the two cases. Chemical analyses, X-ray diffraction, electron microscopy, infrared spectroscopy and thermal analyses were applied to characterize the materials. Dissolution kinetics and drug release kinetics were also investigated, in an ample range of pH (3.0–9.0) in NaCl solutions, and in physiological buffers (1.2, 4.5 and 6.8). All characterization techniques showed that an efficient intercalation of ibuprofen took place, resulting in a material with 30% of its weight corresponding to the drug. On the contrary, all techniques revealed a very poor intercalation of paracetamol (1.2%). The dissolution kinetics of LDHs was highly pH-dependent, being higher as pH decreased. The drug release kinetics, conversely, increased as pH increased. In physiological buffers the release rate depended not only on the pH but also on the type of buffer. This last behavior is useful to control the release in different parts of the digestive system." @default.
• W3124433332 created "2021-02-01" @default.
• W3124433332 creator A5016994685 @default.
• W3124433332 creator A5050951921 @default.
• W3124433332 creator A5087132647 @default.
• W3124433332 creator A5089921705 @default.
• W3124433332 date "2021-04-01" @default.
• W3124433332 modified "2023-09-23" @default.
• W3124433332 title "Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol" @default.
• W3124433332 cites W1557738707 @default.
• W3124433332 cites W174401547 @default.
• W3124433332 cites W1964686432 @default.
• W3124433332 cites W1969876654 @default.
• W3124433332 cites W1972295548 @default.
• W3124433332 cites W1973710255 @default.
• W3124433332 cites W1975506845 @default.
• W3124433332 cites W1981239858 @default.
• W3124433332 cites W1990531990 @default.
• W3124433332 cites W2013744733 @default.
• W3124433332 cites W2023271753 @default.
• W3124433332 cites W2024332630 @default.
• W3124433332 cites W2024392823 @default.
• W3124433332 cites W2030794501 @default.
• W3124433332 cites W2037931064 @default.
• W3124433332 cites W2037954532 @default.
• W3124433332 cites W2047522840 @default.
• W3124433332 cites W2053245497 @default.
• W3124433332 cites W2066450568 @default.
• W3124433332 cites W2069079851 @default.
• W3124433332 cites W2070161113 @default.
• W3124433332 cites W2071364139 @default.
• W3124433332 cites W2073707850 @default.
• W3124433332 cites W2074293847 @default.
• W3124433332 cites W2081339712 @default.
• W3124433332 cites W2085064706 @default.
• W3124433332 cites W2086957099 @default.
• W3124433332 cites W2088199766 @default.
• W3124433332 cites W2088588880 @default.
• W3124433332 cites W2106480132 @default.
• W3124433332 cites W2119804777 @default.
• W3124433332 cites W2137330015 @default.
• W3124433332 cites W2140529950 @default.
• W3124433332 cites W2141621229 @default.
• W3124433332 cites W2601714866 @default.
• W3124433332 cites W2609090528 @default.
• W3124433332 cites W2941612261 @default.
• W3124433332 cites W2972379464 @default.
• W3124433332 cites W382496296 @default.
• W3124433332 doi "https://doi.org/10.1016/j.xphs.2021.01.023" @default.
• W3124433332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33513404" @default.
• W3124433332 hasPublicationYear "2021" @default.
• W3124433332 type Work @default.
• W3124433332 sameAs 3124433332 @default.
• W3124433332 citedByCount "8" @default.
• W3124433332 countsByYear W31244333322021 @default.
• W3124433332 countsByYear W31244333322022 @default.
• W3124433332 countsByYear W31244333322023 @default.
• W3124433332 crossrefType "journal-article" @default.
• W3124433332 hasAuthorship W3124433332A5016994685 @default.
• W3124433332 hasAuthorship W3124433332A5050951921 @default.
• W3124433332 hasAuthorship W3124433332A5087132647 @default.
• W3124433332 hasAuthorship W3124433332A5089921705 @default.
• W3124433332 hasConcept C121332964 @default.
• W3124433332 hasConcept C127413603 @default.
• W3124433332 hasConcept C137824038 @default.
• W3124433332 hasConcept C13965031 @default.
• W3124433332 hasConcept C148898269 @default.
• W3124433332 hasConcept C160892712 @default.
• W3124433332 hasConcept C178790620 @default.
• W3124433332 hasConcept C179104552 @default.
• W3124433332 hasConcept C185592680 @default.
• W3124433332 hasConcept C2775896084 @default.
• W3124433332 hasConcept C2778002958 @default.
• W3124433332 hasConcept C2779944601 @default.
• W3124433332 hasConcept C42360764 @default.
• W3124433332 hasConcept C62520636 @default.
• W3124433332 hasConcept C71924100 @default.
• W3124433332 hasConcept C88380143 @default.
• W3124433332 hasConcept C98274493 @default.
• W3124433332 hasConceptScore W3124433332C121332964 @default.
• W3124433332 hasConceptScore W3124433332C127413603 @default.
• W3124433332 hasConceptScore W3124433332C137824038 @default.
• W3124433332 hasConceptScore W3124433332C13965031 @default.
• W3124433332 hasConceptScore W3124433332C148898269 @default.
• W3124433332 hasConceptScore W3124433332C160892712 @default.
• W3124433332 hasConceptScore W3124433332C178790620 @default.
• W3124433332 hasConceptScore W3124433332C179104552 @default.
• W3124433332 hasConceptScore W3124433332C185592680 @default.
• W3124433332 hasConceptScore W3124433332C2775896084 @default.
• W3124433332 hasConceptScore W3124433332C2778002958 @default.
• W3124433332 hasConceptScore W3124433332C2779944601 @default.
• W3124433332 hasConceptScore W3124433332C42360764 @default.
• W3124433332 hasConceptScore W3124433332C62520636 @default.
• W3124433332 hasConceptScore W3124433332C71924100 @default.
• W3124433332 hasConceptScore W3124433332C88380143 @default.
• W3124433332 hasConceptScore W3124433332C98274493 @default.
• W3124433332 hasFunder F4320321594 @default.
• W3124433332 hasFunder F4320323402 @default.

• next