FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124442391> ?p ?o ?g. }

• W3124442391 endingPage "696" @default.
• W3124442391 startingPage "690" @default.
• W3124442391 abstract "Abstract Objective To assess the correlation between Z‐scores of positive noninvasive prenatal testing (NIPT) results and the positive predictive value (PPV) of NIPT. Methods Pregnancies with positive NIPT results at Guangzhou Women and Children's Medical Centre between July 2017 and May 2020 were included in this study. Fetal karyotyping or microarray analysis was provided to patients with abnormal NIPT results for confirmatory testing. Logistic regression analyses was applied to study the relationship between the Z scores and the PPV performance. The optimal cutoff values for indicating fetal common trisomies were obtained based on receiver operating characteristic (ROC) curve analysis, and then the PPV were calculated in pregnancies with positive NIPT results at Z‐score greater than or equal to cutoff value and in patients with a Z‐score between 3 and cutoff value respectively. Results A total of 214 pregnancies with positive NIPT results for fetal common trisomies were validated by invasive prenatal diagnosis and follow up in this study. Of these, NIPT indicated trisomy 13 in 25 cases, trisomy 18 in 54 cases and trisomy 21 in 135 patients. Logistic regression analyses showed a significant association ( p < 0.05) between the Z‐scores and true positive results for T21 and T18. For T13, the significant association was not observed ( p > 0.05). The ROC curve analysis showed that the optimal cutoff Z‐score for indicating fetal trisomies 13, 18, and 21 were 6.889, 7.574 and 6.612 respectively, and the corresponding area under curve were 0.706, 0.916, and 0.954. In this cohort with abnormal NIPT results, the cutoff values revealed a sensitivity of 96.8% and a specificity of 90% for indicating trisomies 21, and a sensitivity of 88.9% and a specificity of 92.6% for trisomies 18. However, probably due to the sample size, the sensitivity and specificity for indicating trisomy 13 were lower (85.7% and 61.1%) than that for trisomies 21 and 18. The PPVs in pregnancies with positive NIPT results at Z‐score greater than or equal to cutoff value were 99.18% (121/122) for trisomy 21, 92.31% (24/26) for trisomy 18 and 46.15% (6/13) for trisomy 13. In patients with a Z‐score between 3 and cutoff Z‐score, the PPV of NIPT for trisomies 21, 18, and 13 were 30.77% (4/13), 10.71% (3/28), and 8.33% (1/12) respectively. Moreover, by classifying Z scores as 3 ≤ Z < 5, 5 ≤ Z < 10, and Z ≥ 10, the majority of Z scores were above 10 with a PPV of 99% for T21 and just 5.2% were between 3 and 5 with a PPV of 14.3%. In contrast for T18, over a third of tests had Z scores between 3 and 5. The PPV in this group is just over 5%. Conclusions The present results show that the PPV performance of NIPT for fetal trisomies 13, 18, and 21 are closely associated with Z‐score. The higher the Z‐score, the greater the likelihood that the aneuploidy result is correct. Our experience in evaluating the Z‐score accuracy of NIPT in this study could be of use in similar work." @default.
• W3124442391 created "2021-02-01" @default.
• W3124442391 creator A5000534970 @default.
• W3124442391 creator A5006038456 @default.
• W3124442391 creator A5011444305 @default.
• W3124442391 creator A5019373008 @default.
• W3124442391 creator A5025340656 @default.
• W3124442391 creator A5028683686 @default.
• W3124442391 creator A5028855927 @default.
• W3124442391 creator A5033224484 @default.
• W3124442391 creator A5046388547 @default.
• W3124442391 creator A5047778449 @default.
• W3124442391 creator A5054243548 @default.
• W3124442391 creator A5056523704 @default.
• W3124442391 creator A5058188339 @default.
• W3124442391 creator A5060053516 @default.
• W3124442391 creator A5063400789 @default.
• W3124442391 creator A5070855835 @default.
• W3124442391 creator A5073226700 @default.
• W3124442391 creator A5076123883 @default.
• W3124442391 creator A5084492388 @default.
• W3124442391 date "2021-02-11" @default.
• W3124442391 modified "2023-09-27" @default.
• W3124442391 title "Evaluation of the Z‐score accuracy of noninvasive prenatal testing for fetal trisomies 13, 18 and 21 at a single center" @default.
• W3124442391 cites W1499684505 @default.
• W3124442391 cites W1680591717 @default.
• W3124442391 cites W1973063821 @default.
• W3124442391 cites W1990320383 @default.
• W3124442391 cites W2053145197 @default.
• W3124442391 cites W2056703831 @default.
• W3124442391 cites W2078927009 @default.
• W3124442391 cites W2079508370 @default.
• W3124442391 cites W2104478010 @default.
• W3124442391 cites W2124605516 @default.
• W3124442391 cites W2145868259 @default.
• W3124442391 cites W2150176199 @default.
• W3124442391 cites W2151548570 @default.
• W3124442391 cites W2258532034 @default.
• W3124442391 cites W2399534034 @default.
• W3124442391 cites W2413895862 @default.
• W3124442391 cites W2485046853 @default.
• W3124442391 cites W2560057336 @default.
• W3124442391 cites W2604396959 @default.
• W3124442391 cites W2755802330 @default.
• W3124442391 cites W2888023430 @default.
• W3124442391 cites W2901547318 @default.
• W3124442391 cites W2946730479 @default.
• W3124442391 cites W3083641967 @default.
• W3124442391 doi "https://doi.org/10.1002/pd.5908" @default.
• W3124442391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33480032" @default.
• W3124442391 hasPublicationYear "2021" @default.
• W3124442391 type Work @default.
• W3124442391 sameAs 3124442391 @default.
• W3124442391 citedByCount "12" @default.
• W3124442391 countsByYear W31244423912021 @default.
• W3124442391 countsByYear W31244423912022 @default.
• W3124442391 countsByYear W31244423912023 @default.
• W3124442391 crossrefType "journal-article" @default.
• W3124442391 hasAuthorship W3124442391A5000534970 @default.
• W3124442391 hasAuthorship W3124442391A5006038456 @default.
• W3124442391 hasAuthorship W3124442391A5011444305 @default.
• W3124442391 hasAuthorship W3124442391A5019373008 @default.
• W3124442391 hasAuthorship W3124442391A5025340656 @default.
• W3124442391 hasAuthorship W3124442391A5028683686 @default.
• W3124442391 hasAuthorship W3124442391A5028855927 @default.
• W3124442391 hasAuthorship W3124442391A5033224484 @default.
• W3124442391 hasAuthorship W3124442391A5046388547 @default.
• W3124442391 hasAuthorship W3124442391A5047778449 @default.
• W3124442391 hasAuthorship W3124442391A5054243548 @default.
• W3124442391 hasAuthorship W3124442391A5056523704 @default.
• W3124442391 hasAuthorship W3124442391A5058188339 @default.
• W3124442391 hasAuthorship W3124442391A5060053516 @default.
• W3124442391 hasAuthorship W3124442391A5063400789 @default.
• W3124442391 hasAuthorship W3124442391A5070855835 @default.
• W3124442391 hasAuthorship W3124442391A5073226700 @default.
• W3124442391 hasAuthorship W3124442391A5076123883 @default.
• W3124442391 hasAuthorship W3124442391A5084492388 @default.
• W3124442391 hasConcept C121332964 @default.
• W3124442391 hasConcept C126322002 @default.
• W3124442391 hasConcept C131872663 @default.
• W3124442391 hasConcept C151956035 @default.
• W3124442391 hasConcept C172680121 @default.
• W3124442391 hasConcept C2776229224 @default.
• W3124442391 hasConcept C2778217198 @default.
• W3124442391 hasConcept C2778258057 @default.
• W3124442391 hasConcept C2779234561 @default.
• W3124442391 hasConcept C29456083 @default.
• W3124442391 hasConcept C54355233 @default.
• W3124442391 hasConcept C58471807 @default.
• W3124442391 hasConcept C62520636 @default.
• W3124442391 hasConcept C71924100 @default.
• W3124442391 hasConcept C76318530 @default.
• W3124442391 hasConcept C86803240 @default.
• W3124442391 hasConceptScore W3124442391C121332964 @default.
• W3124442391 hasConceptScore W3124442391C126322002 @default.
• W3124442391 hasConceptScore W3124442391C131872663 @default.
• W3124442391 hasConceptScore W3124442391C151956035 @default.
• W3124442391 hasConceptScore W3124442391C172680121 @default.

• next