FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124555438> ?p ?o ?g. }

• W3124555438 endingPage "e1009240" @default.
• W3124555438 startingPage "e1009240" @default.
• W3124555438 abstract "Dengue human infection studies present an opportunity to address many longstanding questions in the field of flavivirus biology. However, limited data are available on how the immunological and transcriptional response elicited by an attenuated challenge virus compares to that associated with a wild-type DENV infection. To determine the kinetic transcriptional signature associated with experimental primary DENV-1 infection and to assess how closely this profile correlates with the transcriptional signature accompanying natural primary DENV-1 infection, we utilized scRNAseq to analyze PBMC from individuals enrolled in a DENV-1 human challenge study and from individuals experiencing a natural primary DENV-1 infection. While both experimental and natural primary DENV-1 infection resulted in overlapping patterns of inflammatory gene upregulation, natural primary DENV-1 infection was accompanied with a more pronounced suppression in gene products associated with protein translation and mitochondrial function, principally in monocytes. This suggests that the immune response elicited by experimental and natural primary DENV infection are similar, but that natural primary DENV-1 infection has a more pronounced impact on basic cellular processes to induce a multi-layered anti-viral state." @default.
• W3124555438 created "2021-02-01" @default.
• W3124555438 creator A5026217717 @default.
• W3124555438 creator A5026726369 @default.
• W3124555438 creator A5027812508 @default.
• W3124555438 creator A5031439855 @default.
• W3124555438 creator A5039786822 @default.
• W3124555438 creator A5041727836 @default.
• W3124555438 creator A5042897977 @default.
• W3124555438 creator A5042963422 @default.
• W3124555438 creator A5044428939 @default.
• W3124555438 creator A5059606373 @default.
• W3124555438 creator A5070380632 @default.
• W3124555438 creator A5072639843 @default.
• W3124555438 creator A5077522136 @default.
• W3124555438 creator A5082727233 @default.
• W3124555438 creator A5083213220 @default.
• W3124555438 creator A5086326013 @default.
• W3124555438 date "2021-01-29" @default.
• W3124555438 modified "2023-10-09" @default.
• W3124555438 title "Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections" @default.
• W3124555438 cites W1883847976 @default.
• W3124555438 cites W1918880335 @default.
• W3124555438 cites W1941946914 @default.
• W3124555438 cites W1971409853 @default.
• W3124555438 cites W2015611314 @default.
• W3124555438 cites W2035509260 @default.
• W3124555438 cites W2055383445 @default.
• W3124555438 cites W2078646756 @default.
• W3124555438 cites W2102826951 @default.
• W3124555438 cites W2105870506 @default.
• W3124555438 cites W2110628545 @default.
• W3124555438 cites W2115005895 @default.
• W3124555438 cites W2116437087 @default.
• W3124555438 cites W2117545797 @default.
• W3124555438 cites W2120756289 @default.
• W3124555438 cites W2123858885 @default.
• W3124555438 cites W2131222241 @default.
• W3124555438 cites W2133402546 @default.
• W3124555438 cites W2134717733 @default.
• W3124555438 cites W2143100474 @default.
• W3124555438 cites W2144628854 @default.
• W3124555438 cites W2149682742 @default.
• W3124555438 cites W2170809965 @default.
• W3124555438 cites W2171200548 @default.
• W3124555438 cites W2184191761 @default.
• W3124555438 cites W2303279226 @default.
• W3124555438 cites W2346569937 @default.
• W3124555438 cites W2763354058 @default.
• W3124555438 cites W2794480084 @default.
• W3124555438 cites W2809307202 @default.
• W3124555438 cites W2905194441 @default.
• W3124555438 cites W2949177718 @default.
• W3124555438 cites W2951506174 @default.
• W3124555438 cites W2993700551 @default.
• W3124555438 cites W2997280954 @default.
• W3124555438 cites W3030274445 @default.
• W3124555438 cites W4211135732 @default.
• W3124555438 doi "https://doi.org/10.1371/journal.ppat.1009240" @default.
• W3124555438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7875406" @default.
• W3124555438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33513191" @default.
• W3124555438 hasPublicationYear "2021" @default.
• W3124555438 type Work @default.
• W3124555438 sameAs 3124555438 @default.
• W3124555438 citedByCount "18" @default.
• W3124555438 countsByYear W31245554382021 @default.
• W3124555438 countsByYear W31245554382022 @default.
• W3124555438 countsByYear W31245554382023 @default.
• W3124555438 crossrefType "journal-article" @default.
• W3124555438 hasAuthorship W3124555438A5026217717 @default.
• W3124555438 hasAuthorship W3124555438A5026726369 @default.
• W3124555438 hasAuthorship W3124555438A5027812508 @default.
• W3124555438 hasAuthorship W3124555438A5031439855 @default.
• W3124555438 hasAuthorship W3124555438A5039786822 @default.
• W3124555438 hasAuthorship W3124555438A5041727836 @default.
• W3124555438 hasAuthorship W3124555438A5042897977 @default.
• W3124555438 hasAuthorship W3124555438A5042963422 @default.
• W3124555438 hasAuthorship W3124555438A5044428939 @default.
• W3124555438 hasAuthorship W3124555438A5059606373 @default.
• W3124555438 hasAuthorship W3124555438A5070380632 @default.
• W3124555438 hasAuthorship W3124555438A5072639843 @default.
• W3124555438 hasAuthorship W3124555438A5077522136 @default.
• W3124555438 hasAuthorship W3124555438A5082727233 @default.
• W3124555438 hasAuthorship W3124555438A5083213220 @default.
• W3124555438 hasAuthorship W3124555438A5086326013 @default.
• W3124555438 hasBestOaLocation W31245554381 @default.
• W3124555438 hasConcept C104317684 @default.
• W3124555438 hasConcept C137061746 @default.
• W3124555438 hasConcept C159047783 @default.
• W3124555438 hasConcept C202751555 @default.
• W3124555438 hasConcept C203014093 @default.
• W3124555438 hasConcept C2522874641 @default.
• W3124555438 hasConcept C2779635636 @default.
• W3124555438 hasConcept C2780568436 @default.
• W3124555438 hasConcept C533803919 @default.
• W3124555438 hasConcept C54355233 @default.
• W3124555438 hasConcept C86803240 @default.
• W3124555438 hasConcept C8891405 @default.

• next