Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124566670> ?p ?o ?g. }
- W3124566670 abstract "Actinomycetes are a rich source of bioactive natural products important for novel drug leads. Recent genome mining approaches have revealed an enormous number of secondary metabolite biosynthetic gene clusters (smBGCs) in actinomycetes. However, under standard laboratory culture conditions, many smBGCs are silent or cryptic. To activate these dormant smBGCs, several approaches, including culture-based or genetic engineering-based strategies, have been developed. Above all, coculture is a promising approach to induce novel secondary metabolite production from actinomycetes by mimicking an ecological habitat where cryptic smBGCs may be activated. In this review, we introduce coculture studies that aim to expand the chemical diversity of actinomycetes, by categorizing the cases by the type of coculture partner. Furthermore, we discuss the current challenges that need to be overcome to support the elicitation of novel bioactive compounds from actinomycetes." @default.
- W3124566670 created "2021-02-01" @default.
- W3124566670 creator A5009338187 @default.
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- W3124566670 creator A5037895785 @default.
- W3124566670 creator A5040782225 @default.
- W3124566670 creator A5091067470 @default.
- W3124566670 date "2021-01-25" @default.
- W3124566670 modified "2023-10-17" @default.
- W3124566670 title "Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture" @default.
- W3124566670 cites W1494067485 @default.
- W3124566670 cites W1575478532 @default.
- W3124566670 cites W1595519404 @default.
- W3124566670 cites W1617751947 @default.
- W3124566670 cites W1701148520 @default.
- W3124566670 cites W1931880308 @default.
- W3124566670 cites W1942636041 @default.
- W3124566670 cites W1967709900 @default.
- W3124566670 cites W1974054733 @default.
- W3124566670 cites W1977485429 @default.
- W3124566670 cites W1977739164 @default.
- W3124566670 cites W1978439945 @default.
- W3124566670 cites W1980713037 @default.
- W3124566670 cites W1987235628 @default.
- W3124566670 cites W1987498936 @default.
- W3124566670 cites W1988032281 @default.
- W3124566670 cites W1988815096 @default.
- W3124566670 cites W1990119536 @default.
- W3124566670 cites W1991470340 @default.
- W3124566670 cites W1991631485 @default.
- W3124566670 cites W1996255717 @default.
- W3124566670 cites W1999742995 @default.
- W3124566670 cites W2006437796 @default.
- W3124566670 cites W2007055380 @default.
- W3124566670 cites W2008288423 @default.
- W3124566670 cites W2008343440 @default.
- W3124566670 cites W2025155908 @default.
- W3124566670 cites W2029783392 @default.
- W3124566670 cites W2031539920 @default.
- W3124566670 cites W2036014552 @default.
- W3124566670 cites W2040539560 @default.
- W3124566670 cites W2040871312 @default.
- W3124566670 cites W2041537722 @default.
- W3124566670 cites W2041612826 @default.
- W3124566670 cites W2044571773 @default.
- W3124566670 cites W2045229137 @default.
- W3124566670 cites W2047114772 @default.
- W3124566670 cites W2047168915 @default.
- W3124566670 cites W2058128635 @default.
- W3124566670 cites W2059857497 @default.
- W3124566670 cites W2061320487 @default.
- W3124566670 cites W2061424627 @default.
- W3124566670 cites W2074812843 @default.
- W3124566670 cites W2077820923 @default.
- W3124566670 cites W2079770491 @default.
- W3124566670 cites W2082658471 @default.
- W3124566670 cites W2087205613 @default.
- W3124566670 cites W2087220873 @default.
- W3124566670 cites W2095895682 @default.
- W3124566670 cites W2097655674 @default.
- W3124566670 cites W2099898297 @default.
- W3124566670 cites W2101916288 @default.
- W3124566670 cites W2108153887 @default.
- W3124566670 cites W2108313755 @default.
- W3124566670 cites W2115486016 @default.
- W3124566670 cites W2117047085 @default.
- W3124566670 cites W2119938020 @default.
- W3124566670 cites W2127240188 @default.
- W3124566670 cites W2127577603 @default.
- W3124566670 cites W2127681878 @default.
- W3124566670 cites W2130083654 @default.
- W3124566670 cites W2130839195 @default.
- W3124566670 cites W2143999510 @default.
- W3124566670 cites W2144181899 @default.
- W3124566670 cites W2146157756 @default.
- W3124566670 cites W2146401071 @default.
- W3124566670 cites W2150262536 @default.
- W3124566670 cites W2151582223 @default.
- W3124566670 cites W2152083550 @default.
- W3124566670 cites W2159105557 @default.
- W3124566670 cites W2164143799 @default.
- W3124566670 cites W2167141095 @default.
- W3124566670 cites W2168519960 @default.
- W3124566670 cites W2169942471 @default.
- W3124566670 cites W2189116376 @default.
- W3124566670 cites W2204847601 @default.
- W3124566670 cites W2295389415 @default.
- W3124566670 cites W2316939010 @default.
- W3124566670 cites W2340649325 @default.
- W3124566670 cites W2343629880 @default.
- W3124566670 cites W2397457481 @default.
- W3124566670 cites W2406620869 @default.
- W3124566670 cites W2413548399 @default.
- W3124566670 cites W24300855 @default.
- W3124566670 cites W2434779010 @default.
- W3124566670 cites W2436067889 @default.
- W3124566670 cites W2505121947 @default.