FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124603615> ?p ?o ?g. }

• W3124603615 endingPage "e656" @default.
• W3124603615 startingPage "e656" @default.
• W3124603615 abstract "Donor-derived cell-free DNA (dd-cfDNA) is a useful biomarker of rejection that originates from allograft cells undergoing injury. Plasma levels <1% in kidney transplant recipients have a high negative predictive value for active allograft rejection. The utility of this biomarker in kidney transplant recipients receiving immune checkpoint inhibitor therapy is unknown.We describe a case in which serial dd-cfDNA monitoring facilitated the use of immune checkpoint inhibitor therapy, which is known to be associated with high rates of rejection, in a kidney transplant recipient with metastatic cancer.A 72-y-old man with end-stage kidney disease secondary to autosomal dominant polycystic kidney disease underwent living unrelated kidney transplant in December 2010. His immunosuppression regimen included tacrolimus, mycophenolate, and prednisone. In July 2017, he presented with metastatic cutaneous squamous cell carcinoma. After his disease progressed through radiation therapy and cetuximab, he received pembrolizumab (antiprogrammed cell death protein 1). His dd-cfDNA level was undetectable at baseline, then increased during treatment but remained <1%. This trend, despite fluctuations in serum creatinine levels during therapy, allowed for continuation of pembrolizumab and successful treatment of his metastatic cancer without clinically evident allograft rejection. After discontinuation of pembrolizumab, dd-cfDNA levels fell below the level of detection. Genetic analysis of the cutaneous squamous cell carcinoma demonstrated a genetic profile distinct from the dd-cfDNA, indicating that tumor lysis did not impact increases in dd-cfDNA.Serial dd-cfDNA measurements may provide a useful, noninvasive biomarker for detecting allograft injury that may facilitate the use of immunomodulatory therapies in organ transplant recipients with cancer." @default.
• W3124603615 created "2021-02-01" @default.
• W3124603615 creator A5004351247 @default.
• W3124603615 creator A5014494747 @default.
• W3124603615 creator A5020054424 @default.
• W3124603615 creator A5020912643 @default.
• W3124603615 creator A5035931636 @default.
• W3124603615 creator A5040976474 @default.
• W3124603615 creator A5061348184 @default.
• W3124603615 creator A5067744023 @default.
• W3124603615 creator A5076711740 @default.
• W3124603615 date "2021-01-15" @default.
• W3124603615 modified "2023-10-01" @default.
• W3124603615 title "Utility of Serial Donor-derived Cell-free DNA Measurements for Detecting Allograft Rejection in a Kidney Transplant Recipient After PD-1 Checkpoint Inhibitor Administration" @default.
• W3124603615 cites W2019607817 @default.
• W3124603615 cites W2024692616 @default.
• W3124603615 cites W2161855894 @default.
• W3124603615 cites W2303235652 @default.
• W3124603615 cites W2528115971 @default.
• W3124603615 cites W2572174216 @default.
• W3124603615 cites W2592945756 @default.
• W3124603615 cites W2593637053 @default.
• W3124603615 cites W2899970113 @default.
• W3124603615 cites W2914696936 @default.
• W3124603615 cites W2944291759 @default.
• W3124603615 cites W2958442515 @default.
• W3124603615 doi "https://doi.org/10.1097/txd.0000000000001113" @default.
• W3124603615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7817285" @default.
• W3124603615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33490381" @default.
• W3124603615 hasPublicationYear "2021" @default.
• W3124603615 type Work @default.
• W3124603615 sameAs 3124603615 @default.
• W3124603615 citedByCount "6" @default.
• W3124603615 countsByYear W31246036152021 @default.
• W3124603615 countsByYear W31246036152022 @default.
• W3124603615 crossrefType "journal-article" @default.
• W3124603615 hasAuthorship W3124603615A5004351247 @default.
• W3124603615 hasAuthorship W3124603615A5014494747 @default.
• W3124603615 hasAuthorship W3124603615A5020054424 @default.
• W3124603615 hasAuthorship W3124603615A5020912643 @default.
• W3124603615 hasAuthorship W3124603615A5035931636 @default.
• W3124603615 hasAuthorship W3124603615A5040976474 @default.
• W3124603615 hasAuthorship W3124603615A5061348184 @default.
• W3124603615 hasAuthorship W3124603615A5067744023 @default.
• W3124603615 hasAuthorship W3124603615A5076711740 @default.
• W3124603615 hasBestOaLocation W31246036151 @default.
• W3124603615 hasConcept C121608353 @default.
• W3124603615 hasConcept C126322002 @default.
• W3124603615 hasConcept C143998085 @default.
• W3124603615 hasConcept C152110520 @default.
• W3124603615 hasConcept C172680121 @default.
• W3124603615 hasConcept C185592680 @default.
• W3124603615 hasConcept C203014093 @default.
• W3124603615 hasConcept C2777701055 @default.
• W3124603615 hasConcept C2778258057 @default.
• W3124603615 hasConcept C2779234561 @default.
• W3124603615 hasConcept C2780057760 @default.
• W3124603615 hasConcept C2780252810 @default.
• W3124603615 hasConcept C2780303639 @default.
• W3124603615 hasConcept C2781068499 @default.
• W3124603615 hasConcept C2781197716 @default.
• W3124603615 hasConcept C2911091166 @default.
• W3124603615 hasConcept C54355233 @default.
• W3124603615 hasConcept C55493867 @default.
• W3124603615 hasConcept C71924100 @default.
• W3124603615 hasConcept C86803240 @default.
• W3124603615 hasConceptScore W3124603615C121608353 @default.
• W3124603615 hasConceptScore W3124603615C126322002 @default.
• W3124603615 hasConceptScore W3124603615C143998085 @default.
• W3124603615 hasConceptScore W3124603615C152110520 @default.
• W3124603615 hasConceptScore W3124603615C172680121 @default.
• W3124603615 hasConceptScore W3124603615C185592680 @default.
• W3124603615 hasConceptScore W3124603615C203014093 @default.
• W3124603615 hasConceptScore W3124603615C2777701055 @default.
• W3124603615 hasConceptScore W3124603615C2778258057 @default.
• W3124603615 hasConceptScore W3124603615C2779234561 @default.
• W3124603615 hasConceptScore W3124603615C2780057760 @default.
• W3124603615 hasConceptScore W3124603615C2780252810 @default.
• W3124603615 hasConceptScore W3124603615C2780303639 @default.
• W3124603615 hasConceptScore W3124603615C2781068499 @default.
• W3124603615 hasConceptScore W3124603615C2781197716 @default.
• W3124603615 hasConceptScore W3124603615C2911091166 @default.
• W3124603615 hasConceptScore W3124603615C54355233 @default.
• W3124603615 hasConceptScore W3124603615C55493867 @default.
• W3124603615 hasConceptScore W3124603615C71924100 @default.
• W3124603615 hasConceptScore W3124603615C86803240 @default.
• W3124603615 hasIssue "2" @default.
• W3124603615 hasLocation W31246036151 @default.
• W3124603615 hasLocation W31246036152 @default.
• W3124603615 hasLocation W31246036153 @default.
• W3124603615 hasLocation W31246036154 @default.
• W3124603615 hasLocation W31246036155 @default.
• W3124603615 hasOpenAccess W3124603615 @default.
• W3124603615 hasPrimaryLocation W31246036151 @default.
• W3124603615 hasRelatedWork W1993894307 @default.
• W3124603615 hasRelatedWork W2018191311 @default.
• W3124603615 hasRelatedWork W2053685147 @default.
• W3124603615 hasRelatedWork W2084149893 @default.

• next