FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124609808> ?p ?o ?g. }

• W3124609808 abstract "The success of boron neutron capture therapy (BNCT) mainly depends on the boron concentration in the tumor and a high tumor/normal tissue (T/N) boron ratio or a high tumor/blood (T/B) boron ratio. Therefore, the effective enhancement of boron ratios is the first priority. Our study investigated whether a low-dose of γ-radiation (LDR) could improve boron ratios and enhance the therapeutic effects of BNCT in an orthotopic human oral squamous cell carcinoma-bearing animal model. SAS/luc cells were used to establish the orthotopic tumor-bearing model. The pharmacokinetics of boronophenylalanine (BPA) administration with 400 mg/kg of body weight both alone and in combination with LDR (0.1 Gy) was evaluated, and BNCT was performed at the Tsing Hua Open-pool Reactor (THOR). The radiation doses were evaluated using a treatment planning system. Moreover, tumor growth and metastasis were monitored via bioluminescence imaging (BLI). The therapeutic effects after BNCT were evaluated using BLI, histopathological findings and the overall survival rate. LDR increased the BPA accumulation in tumors by 52.2%. T/N and T/B ratios were enhanced from 3.77 to 5.31 and from 3.47 to 4.46, respectively. Radiation dose was increased by 44.3%. Notably, tumor recurrence and cervical lymph node metastasis were observed in the BNCT group, which had a survival rate of 50%. Complete responses were found in the combined-treatment group, which had a survival rate of 100%. No toxicity was found according to the histopathological findings. Conclusively, LDR increased BPA accumulation in the tumor and the T/N and T/B ratios, resulting in BNCT efficacy improvement and the overall survival rate extension." @default.
• W3124609808 created "2021-02-01" @default.
• W3124609808 creator A5007089802 @default.
• W3124609808 creator A5016720033 @default.
• W3124609808 creator A5034616182 @default.
• W3124609808 creator A5043017120 @default.
• W3124609808 creator A5054687824 @default.
• W3124609808 date "2021-01-29" @default.
• W3124609808 modified "2023-10-14" @default.
• W3124609808 title "The Effect of Low-Dose Gamma Irradiation on the Uptake of Boronophenylalanine to Enhance the Efficacy of Boron Neutron Capture Therapy in an Orthotopic Oral Cancer Model" @default.
• W3124609808 cites W1168856847 @default.
• W3124609808 cites W1965158281 @default.
• W3124609808 cites W1971792212 @default.
• W3124609808 cites W2003801353 @default.
• W3124609808 cites W2013053295 @default.
• W3124609808 cites W2015050762 @default.
• W3124609808 cites W2044943937 @default.
• W3124609808 cites W2049135568 @default.
• W3124609808 cites W2057194309 @default.
• W3124609808 cites W2078957432 @default.
• W3124609808 cites W2081016347 @default.
• W3124609808 cites W2090091212 @default.
• W3124609808 cites W2104592429 @default.
• W3124609808 cites W2106976207 @default.
• W3124609808 cites W2112347545 @default.
• W3124609808 cites W2115832489 @default.
• W3124609808 cites W2120447583 @default.
• W3124609808 cites W2120942865 @default.
• W3124609808 cites W2147454124 @default.
• W3124609808 cites W2155784435 @default.
• W3124609808 cites W2158351882 @default.
• W3124609808 cites W2166455547 @default.
• W3124609808 cites W2560334792 @default.
• W3124609808 cites W2563101083 @default.
• W3124609808 cites W2605003554 @default.
• W3124609808 cites W2806411025 @default.
• W3124609808 cites W2816342421 @default.
• W3124609808 cites W2900804204 @default.
• W3124609808 cites W2945898219 @default.
• W3124609808 cites W2957724045 @default.
• W3124609808 cites W2963262695 @default.
• W3124609808 cites W2964225845 @default.
• W3124609808 cites W2979874806 @default.
• W3124609808 cites W2997990572 @default.
• W3124609808 cites W2999458027 @default.
• W3124609808 cites W3016717930 @default.
• W3124609808 cites W2092150050 @default.
• W3124609808 doi "https://doi.org/10.1667/rade-20-00102.1" @default.
• W3124609808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33513230" @default.
• W3124609808 hasPublicationYear "2021" @default.
• W3124609808 type Work @default.
• W3124609808 sameAs 3124609808 @default.
• W3124609808 citedByCount "5" @default.
• W3124609808 countsByYear W31246098082021 @default.
• W3124609808 countsByYear W31246098082022 @default.
• W3124609808 countsByYear W31246098082023 @default.
• W3124609808 crossrefType "journal-article" @default.
• W3124609808 hasAuthorship W3124609808A5007089802 @default.
• W3124609808 hasAuthorship W3124609808A5016720033 @default.
• W3124609808 hasAuthorship W3124609808A5034616182 @default.
• W3124609808 hasAuthorship W3124609808A5043017120 @default.
• W3124609808 hasAuthorship W3124609808A5054687824 @default.
• W3124609808 hasConcept C121608353 @default.
• W3124609808 hasConcept C126322002 @default.
• W3124609808 hasConcept C178790620 @default.
• W3124609808 hasConcept C185592680 @default.
• W3124609808 hasConcept C29730261 @default.
• W3124609808 hasConcept C2989005 @default.
• W3124609808 hasConcept C30421969 @default.
• W3124609808 hasConcept C501308230 @default.
• W3124609808 hasConcept C502942594 @default.
• W3124609808 hasConcept C509974204 @default.
• W3124609808 hasConcept C71924100 @default.
• W3124609808 hasConceptScore W3124609808C121608353 @default.
• W3124609808 hasConceptScore W3124609808C126322002 @default.
• W3124609808 hasConceptScore W3124609808C178790620 @default.
• W3124609808 hasConceptScore W3124609808C185592680 @default.
• W3124609808 hasConceptScore W3124609808C29730261 @default.
• W3124609808 hasConceptScore W3124609808C2989005 @default.
• W3124609808 hasConceptScore W3124609808C30421969 @default.
• W3124609808 hasConceptScore W3124609808C501308230 @default.
• W3124609808 hasConceptScore W3124609808C502942594 @default.
• W3124609808 hasConceptScore W3124609808C509974204 @default.
• W3124609808 hasConceptScore W3124609808C71924100 @default.
• W3124609808 hasIssue "4" @default.
• W3124609808 hasLocation W31246098081 @default.
• W3124609808 hasOpenAccess W3124609808 @default.
• W3124609808 hasPrimaryLocation W31246098081 @default.
• W3124609808 hasRelatedWork W1972359505 @default.
• W3124609808 hasRelatedWork W1998853347 @default.
• W3124609808 hasRelatedWork W2023059804 @default.
• W3124609808 hasRelatedWork W2060363677 @default.
• W3124609808 hasRelatedWork W2063366986 @default.
• W3124609808 hasRelatedWork W2072718271 @default.
• W3124609808 hasRelatedWork W2358117442 @default.
• W3124609808 hasRelatedWork W2384708512 @default.
• W3124609808 hasRelatedWork W2952817325 @default.
• W3124609808 hasRelatedWork W30066336 @default.
• W3124609808 hasVolume "195" @default.
• W3124609808 isParatext "false" @default.

• next