FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124678149> ?p ?o ?g. }

• W3124678149 endingPage "860" @default.
• W3124678149 startingPage "852" @default.
• W3124678149 abstract "Chronic kidney disease (CKD) is associated with activated inflammatory responses. Desidustat, a prolyl hydroxylase (PHD) inhibitor is useful for treatment of anemia associated with CKD, but its effect on the inflammatory and fibrotic changes in CKD is not evaluated. In this study, we investigated the effect of desidustat on the inflammatory and fibrotic changes in preclinical models of acute and chronic kidney injury. Acute kidney injury was induced in male Sprague Dawley rats by ischemia-reperfusion, in which effect of desidustat (15 mg/kg, PO) was estimated. In a separate experiment, male C57 mice were treated with adenine for 14 days to induce CKD. These mice were treated with desidustat (15 mg/kg, PO, alternate day) treatment for 14 days, with adenine continued. Desidustat prevented elevation of serum creatinine, urea, IL-1β, IL-6, and kidney injury molecule-1 (KIM-1), and elevated the erythropoietin levels in rats that were subjected to acute kidney injury. Mice treated with adenine developed CKD and anemia, and desidustat treatment caused improvement in serum creatinine, urea, and also improved hemoglobin and reduced hepatic and serum hepcidin. A significant reduction in IL-1β, IL-6, myeloperoxidase (MPO) and oxidative stress was observed by desidustat treatment. Desidustat treatment also reduced renal fibrosis as observed by histological analysis and hydroxyproline content. Desidustat treatment reduced the renal fibrosis and inflammation along with a reduction in anemia in preclinical models of kidney injury, which may translate to protective effects in CKD patients." @default.
• W3124678149 created "2021-02-01" @default.
• W3124678149 creator A5034915854 @default.
• W3124678149 creator A5042106860 @default.
• W3124678149 creator A5049955632 @default.
• W3124678149 creator A5070752590 @default.
• W3124678149 creator A5085056156 @default.
• W3124678149 creator A5089886107 @default.
• W3124678149 date "2021-01-22" @default.
• W3124678149 modified "2023-10-18" @default.
• W3124678149 title "Prolyl hydroxylase inhibitor desidustat protects against acute and chronic kidney injury by reducing inflammatory cytokines and oxidative stress" @default.
• W3124678149 cites W1590457525 @default.
• W3124678149 cites W1944492097 @default.
• W3124678149 cites W1994682152 @default.
• W3124678149 cites W2009192569 @default.
• W3124678149 cites W2021159014 @default.
• W3124678149 cites W2024559429 @default.
• W3124678149 cites W2035264210 @default.
• W3124678149 cites W2058419198 @default.
• W3124678149 cites W2068629997 @default.
• W3124678149 cites W2069070533 @default.
• W3124678149 cites W2071502104 @default.
• W3124678149 cites W2071712379 @default.
• W3124678149 cites W2088866343 @default.
• W3124678149 cites W2093008889 @default.
• W3124678149 cites W2101017316 @default.
• W3124678149 cites W2114363134 @default.
• W3124678149 cites W2129713109 @default.
• W3124678149 cites W2133801643 @default.
• W3124678149 cites W2144762512 @default.
• W3124678149 cites W2145632027 @default.
• W3124678149 cites W2164469730 @default.
• W3124678149 cites W2165347564 @default.
• W3124678149 cites W2170790620 @default.
• W3124678149 cites W2407889154 @default.
• W3124678149 cites W2566509413 @default.
• W3124678149 cites W2607034643 @default.
• W3124678149 cites W2778853238 @default.
• W3124678149 cites W2801814883 @default.
• W3124678149 cites W2811143061 @default.
• W3124678149 cites W2900546761 @default.
• W3124678149 cites W2912140935 @default.
• W3124678149 cites W2945654236 @default.
• W3124678149 cites W2949642899 @default.
• W3124678149 doi "https://doi.org/10.1002/ddr.21792" @default.
• W3124678149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33480036" @default.
• W3124678149 hasPublicationYear "2021" @default.
• W3124678149 type Work @default.
• W3124678149 sameAs 3124678149 @default.
• W3124678149 citedByCount "3" @default.
• W3124678149 countsByYear W31246781492022 @default.
• W3124678149 countsByYear W31246781492023 @default.
• W3124678149 crossrefType "journal-article" @default.
• W3124678149 hasAuthorship W3124678149A5034915854 @default.
• W3124678149 hasAuthorship W3124678149A5042106860 @default.
• W3124678149 hasAuthorship W3124678149A5049955632 @default.
• W3124678149 hasAuthorship W3124678149A5070752590 @default.
• W3124678149 hasAuthorship W3124678149A5085056156 @default.
• W3124678149 hasAuthorship W3124678149A5089886107 @default.
• W3124678149 hasConcept C126322002 @default.
• W3124678149 hasConcept C134018914 @default.
• W3124678149 hasConcept C203565725 @default.
• W3124678149 hasConcept C2776151105 @default.
• W3124678149 hasConcept C2776914184 @default.
• W3124678149 hasConcept C2778176769 @default.
• W3124678149 hasConcept C2778248108 @default.
• W3124678149 hasConcept C2778534260 @default.
• W3124678149 hasConcept C2778653478 @default.
• W3124678149 hasConcept C2780091579 @default.
• W3124678149 hasConcept C2780306776 @default.
• W3124678149 hasConcept C2780472472 @default.
• W3124678149 hasConcept C2780559512 @default.
• W3124678149 hasConcept C71924100 @default.
• W3124678149 hasConcept C98274493 @default.
• W3124678149 hasConceptScore W3124678149C126322002 @default.
• W3124678149 hasConceptScore W3124678149C134018914 @default.
• W3124678149 hasConceptScore W3124678149C203565725 @default.
• W3124678149 hasConceptScore W3124678149C2776151105 @default.
• W3124678149 hasConceptScore W3124678149C2776914184 @default.
• W3124678149 hasConceptScore W3124678149C2778176769 @default.
• W3124678149 hasConceptScore W3124678149C2778248108 @default.
• W3124678149 hasConceptScore W3124678149C2778534260 @default.
• W3124678149 hasConceptScore W3124678149C2778653478 @default.
• W3124678149 hasConceptScore W3124678149C2780091579 @default.
• W3124678149 hasConceptScore W3124678149C2780306776 @default.
• W3124678149 hasConceptScore W3124678149C2780472472 @default.
• W3124678149 hasConceptScore W3124678149C2780559512 @default.
• W3124678149 hasConceptScore W3124678149C71924100 @default.
• W3124678149 hasConceptScore W3124678149C98274493 @default.
• W3124678149 hasIssue "6" @default.
• W3124678149 hasLocation W31246781491 @default.
• W3124678149 hasLocation W31246781492 @default.
• W3124678149 hasOpenAccess W3124678149 @default.
• W3124678149 hasPrimaryLocation W31246781491 @default.
• W3124678149 hasRelatedWork W2042033030 @default.
• W3124678149 hasRelatedWork W2091329577 @default.
• W3124678149 hasRelatedWork W2098830437 @default.
• W3124678149 hasRelatedWork W2127085070 @default.

• next