Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124717840> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3124717840 endingPage "40" @default.
- W3124717840 startingPage "23" @default.
- W3124717840 abstract "The main objective of the present study was to develop proliposomal formulations to enhance the oral bioavailability of rosuvastatin calcium by improving solubility, dissolution and/or intestinal permeability. Proliposomal powder formulations were prepared with drug varying the Phospholipon 90H and cholesterol ratio in the range of 1:0 to 1:1 using pearlitol SD200 as carrier by film deposition method. The prepared proliposomal powder was filled into capsules. The bioavailability enhancement of proliposomes loaded with drug was studied focusing on phospholipid composition and drug:lipid ratio. Prepared proliposomes were characterized for their particle size distribution, zeta potential, entrapment efficiency, in vitro dissolution study and thermal characteristics to understand the phase transition behavior. Further, the formulated proliposomes were subjected to stability behaviour, ex vivo permeation studies using rat intestine followed by in vivo studies. Physicochemical studies help in optimization of formulations. Enhancement in dissolution is due to incorporation of rosuvastatin calcium into the phospholipids and change in the physical state from crystalline to amorphous, thus improving oral bioavailability. Ex vivo studies show significant permeation enhancement across gastrointestinal membrane compared to control. In conclusion, proliposomes provide a powerful and functional way of distribution of inadequately soluble rosuvastatin calcium drug which is proved from in vivo studies based on the enhanced oral delivery. Keywords: Proliposomes, cholesterol, liposomes, permeability, bioavailability Cite this Article Smitha Gandra, S. Sharath C. Reddy, S. Nagasri, V. Vyshnavi, Raju Jukanti. Improved Intestinal Absorption and Bioavailability Enhancement of Rosuvastatin Calcium via Proliposome Powder. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2020; 7(3): 23–40p." @default.
- W3124717840 created "2021-02-01" @default.
- W3124717840 creator A5046948213 @default.
- W3124717840 creator A5050889108 @default.
- W3124717840 creator A5052268358 @default.
- W3124717840 creator A5052360627 @default.
- W3124717840 creator A5077453836 @default.
- W3124717840 date "2021-01-16" @default.
- W3124717840 modified "2023-09-27" @default.
- W3124717840 title "Improved Intestinal Absorption and Bioavailability Enhancement of Rosuvastatin Calcium via Proliposome Powder" @default.
- W3124717840 hasPublicationYear "2021" @default.
- W3124717840 type Work @default.
- W3124717840 sameAs 3124717840 @default.
- W3124717840 citedByCount "0" @default.
- W3124717840 crossrefType "journal-article" @default.
- W3124717840 hasAuthorship W3124717840A5046948213 @default.
- W3124717840 hasAuthorship W3124717840A5050889108 @default.
- W3124717840 hasAuthorship W3124717840A5052268358 @default.
- W3124717840 hasAuthorship W3124717840A5052360627 @default.
- W3124717840 hasAuthorship W3124717840A5077453836 @default.
- W3124717840 hasConcept C112705442 @default.
- W3124717840 hasConcept C125287762 @default.
- W3124717840 hasConcept C155574463 @default.
- W3124717840 hasConcept C155672457 @default.
- W3124717840 hasConcept C159985019 @default.
- W3124717840 hasConcept C171250308 @default.
- W3124717840 hasConcept C178790620 @default.
- W3124717840 hasConcept C181389837 @default.
- W3124717840 hasConcept C185154212 @default.
- W3124717840 hasConcept C185592680 @default.
- W3124717840 hasConcept C192562407 @default.
- W3124717840 hasConcept C202751555 @default.
- W3124717840 hasConcept C26291073 @default.
- W3124717840 hasConcept C2780499067 @default.
- W3124717840 hasConcept C2908737378 @default.
- W3124717840 hasConcept C41625074 @default.
- W3124717840 hasConcept C43617362 @default.
- W3124717840 hasConcept C50670333 @default.
- W3124717840 hasConcept C519063684 @default.
- W3124717840 hasConcept C55493867 @default.
- W3124717840 hasConcept C71924100 @default.
- W3124717840 hasConcept C86181022 @default.
- W3124717840 hasConcept C98274493 @default.
- W3124717840 hasConceptScore W3124717840C112705442 @default.
- W3124717840 hasConceptScore W3124717840C125287762 @default.
- W3124717840 hasConceptScore W3124717840C155574463 @default.
- W3124717840 hasConceptScore W3124717840C155672457 @default.
- W3124717840 hasConceptScore W3124717840C159985019 @default.
- W3124717840 hasConceptScore W3124717840C171250308 @default.
- W3124717840 hasConceptScore W3124717840C178790620 @default.
- W3124717840 hasConceptScore W3124717840C181389837 @default.
- W3124717840 hasConceptScore W3124717840C185154212 @default.
- W3124717840 hasConceptScore W3124717840C185592680 @default.
- W3124717840 hasConceptScore W3124717840C192562407 @default.
- W3124717840 hasConceptScore W3124717840C202751555 @default.
- W3124717840 hasConceptScore W3124717840C26291073 @default.
- W3124717840 hasConceptScore W3124717840C2780499067 @default.
- W3124717840 hasConceptScore W3124717840C2908737378 @default.
- W3124717840 hasConceptScore W3124717840C41625074 @default.
- W3124717840 hasConceptScore W3124717840C43617362 @default.
- W3124717840 hasConceptScore W3124717840C50670333 @default.
- W3124717840 hasConceptScore W3124717840C519063684 @default.
- W3124717840 hasConceptScore W3124717840C55493867 @default.
- W3124717840 hasConceptScore W3124717840C71924100 @default.
- W3124717840 hasConceptScore W3124717840C86181022 @default.
- W3124717840 hasConceptScore W3124717840C98274493 @default.
- W3124717840 hasIssue "3" @default.
- W3124717840 hasLocation W31247178401 @default.
- W3124717840 hasOpenAccess W3124717840 @default.
- W3124717840 hasPrimaryLocation W31247178401 @default.
- W3124717840 hasRelatedWork W1953269783 @default.
- W3124717840 hasRelatedWork W1970000720 @default.
- W3124717840 hasRelatedWork W1980896120 @default.
- W3124717840 hasRelatedWork W2014196311 @default.
- W3124717840 hasRelatedWork W2020102929 @default.
- W3124717840 hasRelatedWork W2092110267 @default.
- W3124717840 hasRelatedWork W2610799360 @default.
- W3124717840 hasRelatedWork W2795621675 @default.
- W3124717840 hasRelatedWork W2829237472 @default.
- W3124717840 hasRelatedWork W2950893525 @default.
- W3124717840 hasRelatedWork W2951463094 @default.
- W3124717840 hasRelatedWork W2998889154 @default.
- W3124717840 hasRelatedWork W3012446953 @default.
- W3124717840 hasRelatedWork W3026004378 @default.
- W3124717840 hasRelatedWork W3109152888 @default.
- W3124717840 hasRelatedWork W3109291160 @default.
- W3124717840 hasRelatedWork W3119971136 @default.
- W3124717840 hasRelatedWork W3207827260 @default.
- W3124717840 hasRelatedWork W2346245384 @default.
- W3124717840 hasRelatedWork W2994661161 @default.
- W3124717840 hasVolume "7" @default.
- W3124717840 isParatext "false" @default.
- W3124717840 isRetracted "false" @default.
- W3124717840 magId "3124717840" @default.
- W3124717840 workType "article" @default.