Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124790106> ?p ?o ?g. }
- W3124790106 abstract "Abstract Accurate decoding of nucleic acid variation is critical to understand the complexity and regulation of genome function. Here we use a single-molecule magnetic tweezer (MT) platform to identify sequence variation and map a range of important epigenetic base modifications with high sensitivity, specificity, and precision in the same single molecules of DNA or RNA. We have also developed a highly specific amplification-free CRISPR-Cas enrichment strategy to isolate genomic regions from native DNA. We demonstrate enrichment of DNA from both E. coli and the FMR1 5’UTR coming from cells derived from a Fragile X carrier. From these kilobase-length enriched molecules we could characterize the differential levels of adenine and cytosine base modifications on E. coli , and the repeat expansion length and methylation status of FMR1 . Together these results demonstrate that our platform can detect a variety of genetic, epigenetic, and base modification changes concomitantly within the same single molecules." @default.
- W3124790106 created "2021-02-01" @default.
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- W3124790106 date "2021-01-29" @default.
- W3124790106 modified "2023-10-15" @default.
- W3124790106 title "Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA" @default.
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- W3124790106 doi "https://doi.org/10.1038/s42003-021-01648-7" @default.
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