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- W3124806095 abstract "Background: Ghana adopted the treat all policy in 2016 working towards achieving the UNAIDS 90-90-90 target by 2020. Human immunodeficiency virus (HIV) testing algorithms based on rapid diagnostic tests (RDTs) are widely used for HIV testing and counselling programs in areas with limited laboratory capacity, including Ghana. Bad weather and improper storage could affect the test kits and result in wrong diagnosis. The WHO therefore recommends periodic post market assessment of these test kits. However, little is known about the performance of these test in the Wa municipal several years after they have been deployed for HIV testing in the Upper West Region. We assessed the sensitivity and the specificity of First Response and OraQuick HIV RDT kits in the Wa municipality. Methods and materials: We conveniently sampled 286 subjects at the Wa Regional Hospital blood donation center and the voluntary counselling and testing unit. We used a questionnaire to collect demographic information of the subjects. We tested each subject with First Response and OraQuick test kits using parallel algorithm. We collected venous blood samples of the subjects into SST tubes for ELISA at the National Public Health and Reference Laboratory. We analyzed data into frequencies and determined the sensitivity, specificity and predictive values of the test kits using STATA. Results: The sensitivity of First Response was 88% and OraQuick 98%. The specificity of First Response was 92% and OraQuick 94%. The PPV for First response was 91% and OraQuick 95%. First Response had NPV of 89% and OraQuick 98%. There was a single case of HIV false positive on Anti-retroviral therapy. Conclusion: The two test kits being used in the Upper West Region performed below the WHO recommendations. The general performance of OraQuick was however better than First Response. We recommended that National AIDS Control Programme and the Food and Drugs Authority should reassess the test kits and that is being carried out." @default.
- W3124806095 created "2021-02-01" @default.
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- W3124806095 date "2020-12-01" @default.
- W3124806095 modified "2023-09-25" @default.
- W3124806095 title "Post-market assessment of two rapid diagnostic test kits used in the diagnosis of HIV in the Wa municipality - Ghana, 2018" @default.
- W3124806095 doi "https://doi.org/10.1016/j.ijid.2020.09.748" @default.
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