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• W3124821859 abstract "Introduction Bilateral ureteral reimplantation at the time of the complete primary repair of bladder exstrophy (BUR-CPRE) has been proposed and has demonstrated favorable outcomes in the past. However, the potential benefits, including prevention of vesicoureteral reflux (VUR) and renal scarring must be tempered with any risks of reimplantation, persistent VUR, and the potential for overtreatment. We aimed to determine the impact of BUR-CPRE on reflux rates, renogram findings and bladder capacity. Methods An IRB approved registry of children treated for bladder exstrophy epispadias complex (BEEC) during a long-term international collaboration hosted in a region with high prevalence of BEEC was queried. Children undergoing primary CPRE for bladder exstrophy (BE) were identified. Surgical procedure and outcome measures nuclear medicine dimercaptosuccinic acid (DMSA) scintigraphy scans, voiding cystourethrogram (VCUG), and urodynamic study (UDS) were assessed for presence and degree of VUR, renogram abnormalities, and bladder capacity. Results A total cohort of 147 patients with BEEC was queried; 52 children (37 males, 71%) underwent primary CPRE for BE between 2009 and 2019 at median age of 1.1 years (IQR 0.6–1.9 years) with median follow up 4.4 years (IQR 2.4–6.4 years). BUR-CPRE was performed in 22/52 (42%). After BUR-CPRE, children were less likely to have VUR (any VUR present in 9 of 20 with imaging (45%) compared to 23 of 26 with imaging (82%) in the CPRE alone group (p = 0.007)). VUR in the BUR-CPRE group tended to be unilateral and lower grade in comparison to the CPRE alone group. DMSA abnormalities were less common in the BUR-CPRE group (4/19 (21%) vs.12/27 (44%)), although the difference did not reach statistical significance (p = 0.1). At 4 years follow-up, the BUR-CPRE group had a larger bladder capacity (p = 0.016). Discussion After BUR-CPRE, children had a lower rate of VUR, and when present, VUR was more often unilateral and lower grade compared to the CPRE alone group. Fewer numbers of children in the BUR-CPRE group depicted DMSA abnormalities. No children developed obstruction after BUR-CPRE and none have undergone repeat reimplantation. We documented a larger bladder capacity at the time of maximum follow-up available (4 years)—but further data are needed to confirm this observation. Conclusion Summary TablePrimary outcomes – VUR status and DMSA abnormalities Outcome BUR at the time of CPRE (n = 20) No BUR at time of CPRE (n = 28) p-value Any VUR present∗ 9 (45%) 23 (82%) 0.007 Bilateral VUR∗ 4 (20%) 19 (68%) 0.004 High-grade VUR∗ (grades 4 or 5) 2 (10%) 11 (44%) 0.016 DMSA abnormalities 4/19 (21%) 12/27 (44%) 0.1 Bladder capacity at 1 year of follow-up (n, median, IQR) N = 19Median = 20 (15–30) ml N = 13Median = 30 (15–40) ml 0.25 Bladder capacity at 4 years of follow-up (n, median, IQR)∗ N = 6Median = 78.5 (60–130) ml N = 16Median = 40 (32–56) ml 0.02 Open table in a new tab" @default.
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• W3124821859 date "2021-06-01" @default.
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• W3124821859 title "Impact of bilateral ureteral reimplantation at the time of complete primary repair of bladder exstrophy on reflux rates, renogram abnormalities and bladder capacity" @default.
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• W3124821859 doi "https://doi.org/10.1016/j.jpurol.2021.01.020" @default.
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