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• W3124858898 abstract "Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes. Triple‑negative breast cancer (TNBC) is difficult‑to‑treat, pro-inflammatory and highly metastatic. We demonstrate that TNBC cells express TLR9, are responsive to TLR9 ligands, and treatment of TNBC cells with chemotherapy increases the release of nucleic acid-containing Damage Associated Molecular Patterns (DAMPs) in cell culture. Such culture-derived and BC-patient derived DAMPs increase TLR9 activation and TNBC cell invasion in vitro. Notably, treatment with the nucleic acid scavenger (NAS) PAMAM-G3 significantly mitigates such effects. In mice that develop spontaneous BC induced by polyoma middle T oncoprotein (MMTV-PyMT), treatment with NAS reduced lung metastasis. Thus, NAS treatment may mitigate cancer induced inflammation and metastasis and represents a novel therapeutic approach for combating breast cancer." @default.
• W3124858898 created "2021-02-01" @default.
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• W3124858898 date "2020-01-01" @default.
• W3124858898 modified "2023-09-27" @default.
• W3124858898 title "Nucleic-Acid Scavengers Mitigate Breast Cancer Induced Inflammation, Invasion, and Metastasis" @default.
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• W3124858898 doi "https://doi.org/10.2139/ssrn.3748589" @default.
• W3124858898 hasPublicationYear "2020" @default.
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