FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124877883> ?p ?o ?g. }

• W3124877883 abstract "Abstract Protein structure and dynamics can be probed using X-ray crystallography. Whereas the Bragg peaks are only sensitive to the average unit-cell electron density, the signal between the Bragg peaks -- diffuse scattering -- is sensitive to spatial correlations in electron-density variations. Although diffuse scattering contains valuable information about protein dynamics, the diffuse signal is more difficult to isolate from the background compared to the Bragg signal, and the reproducibility of diffuse signal is not yet well understood. We present a systematic study of the reproducibility of diffuse scattering from isocyanide hydratase (ICH) in three different protein forms. Both replicate diffuse datasets and datasets obtained from different mutants were similar in pairwise comparisons (Pearson correlation coefficient (CC) ≥0.8). The data were processed in a manner inspired by previously published methods using custom software with modular design, enabling us to perform an analysis of various data processing choices to determine how to obtain the highest quality data as assessed using unbiased measures of symmetry and reproducibility. The diffuse data then were used to characterize atomic mobility using a liquid-like motions (LLM) model. This characterization was able to discriminate between distinct anisotropic atomic displacement parameter (ADP) models arising from different anisotropic scaling choices that agreed comparably with the Bragg data. Our results emphasize the importance of data reproducibility as a model-free measure of diffuse data quality, illustrate the ability of LLM analysis of diffuse scattering to select among alternative ADP models, and offer insights into the design of successful diffuse scattering experiments." @default.
• W3124877883 created "2021-02-01" @default.
• W3124877883 creator A5005718983 @default.
• W3124877883 creator A5022059748 @default.
• W3124877883 creator A5030457068 @default.
• W3124877883 creator A5030920869 @default.
• W3124877883 creator A5041973369 @default.
• W3124877883 creator A5056060411 @default.
• W3124877883 creator A5066230952 @default.
• W3124877883 creator A5082562968 @default.
• W3124877883 date "2021-01-26" @default.
• W3124877883 modified "2023-10-16" @default.
• W3124877883 title "Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters" @default.
• W3124877883 cites W1524947750 @default.
• W3124877883 cites W1545998089 @default.
• W3124877883 cites W1963551611 @default.
• W3124877883 cites W1977457371 @default.
• W3124877883 cites W1992652354 @default.
• W3124877883 cites W1997145576 @default.
• W3124877883 cites W2002211468 @default.
• W3124877883 cites W2007876421 @default.
• W3124877883 cites W2019701891 @default.
• W3124877883 cites W2020002529 @default.
• W3124877883 cites W2020657023 @default.
• W3124877883 cites W2033053209 @default.
• W3124877883 cites W2033885033 @default.
• W3124877883 cites W2061224013 @default.
• W3124877883 cites W2072593380 @default.
• W3124877883 cites W2085701920 @default.
• W3124877883 cites W2108921801 @default.
• W3124877883 cites W2108959691 @default.
• W3124877883 cites W2110808180 @default.
• W3124877883 cites W2116305502 @default.
• W3124877883 cites W2131417105 @default.
• W3124877883 cites W2139654449 @default.
• W3124877883 cites W2143408543 @default.
• W3124877883 cites W2159211495 @default.
• W3124877883 cites W2163804195 @default.
• W3124877883 cites W2180229411 @default.
• W3124877883 cites W2264985423 @default.
• W3124877883 cites W2318560876 @default.
• W3124877883 cites W2620265724 @default.
• W3124877883 cites W2793311671 @default.
• W3124877883 cites W2906334883 @default.
• W3124877883 cites W2913847888 @default.
• W3124877883 cites W2951455412 @default.
• W3124877883 cites W2952770773 @default.
• W3124877883 cites W2995667212 @default.
• W3124877883 cites W3006322941 @default.
• W3124877883 cites W3014674861 @default.
• W3124877883 cites W3102129664 @default.
• W3124877883 cites W3103145119 @default.
• W3124877883 cites W4210675630 @default.
• W3124877883 cites W4230546834 @default.
• W3124877883 cites W4248872320 @default.
• W3124877883 doi "https://doi.org/10.1101/2021.01.24.428002" @default.
• W3124877883 hasPublicationYear "2021" @default.
• W3124877883 type Work @default.
• W3124877883 sameAs 3124877883 @default.
• W3124877883 citedByCount "0" @default.
• W3124877883 crossrefType "posted-content" @default.
• W3124877883 hasAuthorship W3124877883A5005718983 @default.
• W3124877883 hasAuthorship W3124877883A5022059748 @default.
• W3124877883 hasAuthorship W3124877883A5030457068 @default.
• W3124877883 hasAuthorship W3124877883A5030920869 @default.
• W3124877883 hasAuthorship W3124877883A5041973369 @default.
• W3124877883 hasAuthorship W3124877883A5056060411 @default.
• W3124877883 hasAuthorship W3124877883A5066230952 @default.
• W3124877883 hasAuthorship W3124877883A5082562968 @default.
• W3124877883 hasBestOaLocation W31248778831 @default.
• W3124877883 hasConcept C105795698 @default.
• W3124877883 hasConcept C120665830 @default.
• W3124877883 hasConcept C121332964 @default.
• W3124877883 hasConcept C168834538 @default.
• W3124877883 hasConcept C186060115 @default.
• W3124877883 hasConcept C191486275 @default.
• W3124877883 hasConcept C192562407 @default.
• W3124877883 hasConcept C2780944729 @default.
• W3124877883 hasConcept C30475298 @default.
• W3124877883 hasConcept C33923547 @default.
• W3124877883 hasConcept C86803240 @default.
• W3124877883 hasConcept C9893847 @default.
• W3124877883 hasConceptScore W3124877883C105795698 @default.
• W3124877883 hasConceptScore W3124877883C120665830 @default.
• W3124877883 hasConceptScore W3124877883C121332964 @default.
• W3124877883 hasConceptScore W3124877883C168834538 @default.
• W3124877883 hasConceptScore W3124877883C186060115 @default.
• W3124877883 hasConceptScore W3124877883C191486275 @default.
• W3124877883 hasConceptScore W3124877883C192562407 @default.
• W3124877883 hasConceptScore W3124877883C2780944729 @default.
• W3124877883 hasConceptScore W3124877883C30475298 @default.
• W3124877883 hasConceptScore W3124877883C33923547 @default.
• W3124877883 hasConceptScore W3124877883C86803240 @default.
• W3124877883 hasConceptScore W3124877883C9893847 @default.
• W3124877883 hasLocation W31248778831 @default.
• W3124877883 hasLocation W31248778832 @default.
• W3124877883 hasLocation W31248778833 @default.
• W3124877883 hasLocation W31248778834 @default.
• W3124877883 hasOpenAccess W3124877883 @default.
• W3124877883 hasPrimaryLocation W31248778831 @default.

• next