FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124916438> ?p ?o ?g. }

• W3124916438 abstract "Mutation of purR was previously shown to enhance the virulence of Staphylococcus aureus in a murine sepsis model, and this cannot be fully explained by increased expression of genes within the purine biosynthesis pathway. Rather, the increased production of specific S. aureus virulence factors, including alpha toxin and the fibronectin-binding proteins, was shown to play an important role. Mutation of purR was also shown previously to result in increased abundance of SarA. Here, we demonstrate by transposon sequencing that mutation of purR in the USA300 strain LAC increases fitness in a biofilm while mutation of sarA has the opposite effect. Therefore, we assessed the impact of sarA on reported purR-associated phenotypes by characterizing isogenic purR, sarA, and sarA/purR mutants. The results confirmed that mutation of purR results in increased abundance of alpha toxin, protein A, the fibronectin-binding proteins, and SarA, decreased production of extracellular proteases, an increased capacity to form a biofilm, and increased virulence in an osteomyelitis model. Mutation of sarA had the opposite effects on all of these phenotypes and, other than bacterial burdens in the bone, all of the phenotypes of sarA/purR mutants were comparable to those of sarA mutants. Limiting the production of extracellular proteases reversed all of the phenotypes of sarA mutants and most of those of sarA/purR mutants. We conclude that a critical component defining the virulence of a purR mutant is the enhanced production of SarA, which limits protease production to an extent that promotes the accumulation of critical S. aureus virulence factors." @default.
• W3124916438 created "2021-02-01" @default.
• W3124916438 creator A5007314004 @default.
• W3124916438 creator A5052367201 @default.
• W3124916438 creator A5065068682 @default.
• W3124916438 creator A5071433358 @default.
• W3124916438 creator A5075031124 @default.
• W3124916438 creator A5076939588 @default.
• W3124916438 date "2021-03-17" @default.
• W3124916438 modified "2023-10-16" @default.
• W3124916438 title "The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a <i>purR</i> Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases" @default.
• W3124916438 cites W1572163329 @default.
• W3124916438 cites W1870356554 @default.
• W3124916438 cites W1903035930 @default.
• W3124916438 cites W1987294201 @default.
• W3124916438 cites W1997584741 @default.
• W3124916438 cites W2016045705 @default.
• W3124916438 cites W2030924818 @default.
• W3124916438 cites W2055989417 @default.
• W3124916438 cites W2067234598 @default.
• W3124916438 cites W2094450113 @default.
• W3124916438 cites W2094667070 @default.
• W3124916438 cites W2094958156 @default.
• W3124916438 cites W2101525773 @default.
• W3124916438 cites W2102360445 @default.
• W3124916438 cites W2105466259 @default.
• W3124916438 cites W2106092196 @default.
• W3124916438 cites W2120735676 @default.
• W3124916438 cites W2127113854 @default.
• W3124916438 cites W2127498551 @default.
• W3124916438 cites W2143185955 @default.
• W3124916438 cites W2147841875 @default.
• W3124916438 cites W2150131459 @default.
• W3124916438 cites W2161886493 @default.
• W3124916438 cites W2218387596 @default.
• W3124916438 cites W2235116982 @default.
• W3124916438 cites W2286261581 @default.
• W3124916438 cites W2313619242 @default.
• W3124916438 cites W2346301418 @default.
• W3124916438 cites W2418745797 @default.
• W3124916438 cites W2462174854 @default.
• W3124916438 cites W2480204899 @default.
• W3124916438 cites W2606636476 @default.
• W3124916438 cites W2611236744 @default.
• W3124916438 cites W2729754411 @default.
• W3124916438 cites W2755460299 @default.
• W3124916438 cites W2770152359 @default.
• W3124916438 cites W2791280341 @default.
• W3124916438 cites W2808318509 @default.
• W3124916438 cites W2892041266 @default.
• W3124916438 cites W2909831596 @default.
• W3124916438 cites W2914290436 @default.
• W3124916438 cites W2943273540 @default.
• W3124916438 cites W2950015644 @default.
• W3124916438 cites W2988983324 @default.
• W3124916438 cites W2989733451 @default.
• W3124916438 cites W2991307198 @default.
• W3124916438 cites W3006876275 @default.
• W3124916438 cites W3024716087 @default.
• W3124916438 cites W4254687493 @default.
• W3124916438 doi "https://doi.org/10.1128/iai.00718-20" @default.
• W3124916438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8090970" @default.
• W3124916438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33468580" @default.
• W3124916438 hasPublicationYear "2021" @default.
• W3124916438 type Work @default.
• W3124916438 sameAs 3124916438 @default.
• W3124916438 citedByCount "6" @default.
• W3124916438 countsByYear W31249164382021 @default.
• W3124916438 countsByYear W31249164382022 @default.
• W3124916438 countsByYear W31249164382023 @default.
• W3124916438 crossrefType "journal-article" @default.
• W3124916438 hasAuthorship W3124916438A5007314004 @default.
• W3124916438 hasAuthorship W3124916438A5052367201 @default.
• W3124916438 hasAuthorship W3124916438A5065068682 @default.
• W3124916438 hasAuthorship W3124916438A5071433358 @default.
• W3124916438 hasAuthorship W3124916438A5075031124 @default.
• W3124916438 hasAuthorship W3124916438A5076939588 @default.
• W3124916438 hasBestOaLocation W31249164382 @default.
• W3124916438 hasConcept C104317684 @default.
• W3124916438 hasConcept C127716648 @default.
• W3124916438 hasConcept C143065580 @default.
• W3124916438 hasConcept C181199279 @default.
• W3124916438 hasConcept C182220744 @default.
• W3124916438 hasConcept C2779489039 @default.
• W3124916438 hasConcept C2781090273 @default.
• W3124916438 hasConcept C28406088 @default.
• W3124916438 hasConcept C501734568 @default.
• W3124916438 hasConcept C523546767 @default.
• W3124916438 hasConcept C54355233 @default.
• W3124916438 hasConcept C55493867 @default.
• W3124916438 hasConcept C60987743 @default.
• W3124916438 hasConcept C86803240 @default.
• W3124916438 hasConcept C89423630 @default.
• W3124916438 hasConceptScore W3124916438C104317684 @default.
• W3124916438 hasConceptScore W3124916438C127716648 @default.
• W3124916438 hasConceptScore W3124916438C143065580 @default.
• W3124916438 hasConceptScore W3124916438C181199279 @default.
• W3124916438 hasConceptScore W3124916438C182220744 @default.
• W3124916438 hasConceptScore W3124916438C2779489039 @default.
• W3124916438 hasConceptScore W3124916438C2781090273 @default.

• next