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- W3124921669 abstract "Floating spheroidal aggregates of mouse embryonic stem cells can develop into polarized/elongated organoids, namely gastruloids. We set up a high-performing assay to measure gastruloid formation efficiency (GFE), and found that GFE decreases as pluripotency progresses from naive (GFE ≥ 95%) to primed (GFE = 0) state. Specifically, we show that primed EpiSCs fail to generate proper cell aggregates, while early-primed EpiLCs aggregate but eventually fail to develop into elongated gastruloids. Moreover, we characterized proline-induced cells (PiCs), a LIF-dependent reversible early-primed state of pluripotency, and show that PiCs are able to generate gastruloids (GFE ∼ 50%) and are also competent to differentiate into primordial germ cell-like cells. Thus, we propose the GFE assay as a valuable functional tool to discriminate different states of the pluripotency continuum." @default.
- W3124921669 created "2021-02-01" @default.
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- W3124921669 date "2021-02-01" @default.
- W3124921669 modified "2023-10-16" @default.
- W3124921669 title "Gastruloid Development Competence Discriminates Different States of Pluripotency" @default.
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- W3124921669 doi "https://doi.org/10.1016/j.stemcr.2020.12.013" @default.
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