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• W3124932017 endingPage "105827" @default.
• W3124932017 startingPage "105827" @default.
• W3124932017 abstract "Progesterone modulates many processes in the body, acting through nuclear receptors (nPR) in various organs and tissues. However, a number of effects are mediated by membrane progesterone receptors (mPRs), which are members of the progestin and adipoQ (PAQR) receptor family. These receptors are found in most tissues and immune cells. They are expressed in various cancer cells and appear to play an important role in the development of tumors. The role of mPRs in the development of insulin resistance and metabolic syndrome has also attracted attention. Since progesterone efficiently binds to both nPRs and mPRs, investigation of the functions of the mPRs both at the level of the whole body and at the cell level requires ligands that selectively interact with mPRs, but not with nPRs, with an affinity comparable with that of the natural hormone. The development of such ligands faces difficulties primarily due to the lack of data on the three-dimensional structure of the ligand-binding site of mPR. This review is the first attempt to summarize available data on the structures of compounds interacting with mPRs and analyze them in terms of the differences in binding to membrane and nuclear receptors. Based on the identified main structural fragments of molecules, which affect the efficiency of binding to mPRs and are responsible for the selectivity of interactions, we propose directions of modification of the steroid scaffold to create new selective mPRs ligands." @default.
• W3124932017 created "2021-02-01" @default.
• W3124932017 creator A5004093801 @default.
• W3124932017 creator A5050018783 @default.
• W3124932017 creator A5067771992 @default.
• W3124932017 creator A5081425605 @default.
• W3124932017 date "2021-03-01" @default.
• W3124932017 modified "2023-10-04" @default.
• W3124932017 title "Selective ligands of membrane progesterone receptors as a key to studying their biological functions in vitro and in vivo" @default.
• W3124932017 cites W1179637309 @default.
• W3124932017 cites W1907321242 @default.
• W3124932017 cites W1964029531 @default.
• W3124932017 cites W1968480446 @default.
• W3124932017 cites W1971532261 @default.
• W3124932017 cites W1979636612 @default.
• W3124932017 cites W1982941640 @default.
• W3124932017 cites W1984751527 @default.
• W3124932017 cites W1986206057 @default.
• W3124932017 cites W1988676996 @default.
• W3124932017 cites W1993452986 @default.
• W3124932017 cites W1994672969 @default.
• W3124932017 cites W2005050501 @default.
• W3124932017 cites W2005353812 @default.
• W3124932017 cites W2012255717 @default.
• W3124932017 cites W2014370769 @default.
• W3124932017 cites W2014442933 @default.
• W3124932017 cites W2030555662 @default.
• W3124932017 cites W2036287976 @default.
• W3124932017 cites W2036451134 @default.
• W3124932017 cites W2044152222 @default.
• W3124932017 cites W2045973849 @default.
• W3124932017 cites W2046358196 @default.
• W3124932017 cites W2070156806 @default.
• W3124932017 cites W2082926621 @default.
• W3124932017 cites W2087561186 @default.
• W3124932017 cites W2098963564 @default.
• W3124932017 cites W2117645041 @default.
• W3124932017 cites W2119937601 @default.
• W3124932017 cites W2120895898 @default.
• W3124932017 cites W2125367143 @default.
• W3124932017 cites W2131061165 @default.
• W3124932017 cites W2133341433 @default.
• W3124932017 cites W2134419353 @default.
• W3124932017 cites W2154844619 @default.
• W3124932017 cites W2163218569 @default.
• W3124932017 cites W2165403578 @default.
• W3124932017 cites W2171021705 @default.
• W3124932017 cites W2174560127 @default.
• W3124932017 cites W2193944659 @default.
• W3124932017 cites W22744554 @default.
• W3124932017 cites W2278992199 @default.
• W3124932017 cites W2281734632 @default.
• W3124932017 cites W2286310281 @default.
• W3124932017 cites W2327714939 @default.
• W3124932017 cites W2465571301 @default.
• W3124932017 cites W2466653524 @default.
• W3124932017 cites W2498954697 @default.
• W3124932017 cites W2566707067 @default.
• W3124932017 cites W2585251380 @default.
• W3124932017 cites W2664285244 @default.
• W3124932017 cites W2724282355 @default.
• W3124932017 cites W2737691306 @default.
• W3124932017 cites W2758086724 @default.
• W3124932017 cites W2783187175 @default.
• W3124932017 cites W2803910595 @default.
• W3124932017 cites W2805203076 @default.
• W3124932017 cites W2808683307 @default.
• W3124932017 cites W2889236922 @default.
• W3124932017 cites W2905457396 @default.
• W3124932017 cites W2913625334 @default.
• W3124932017 cites W2916928708 @default.
• W3124932017 cites W2921576806 @default.
• W3124932017 cites W2950716936 @default.
• W3124932017 cites W2954149403 @default.
• W3124932017 cites W2964131578 @default.
• W3124932017 cites W2967818490 @default.
• W3124932017 cites W2971042146 @default.
• W3124932017 cites W2980324624 @default.
• W3124932017 cites W2990554747 @default.
• W3124932017 cites W2991862301 @default.
• W3124932017 cites W3007113358 @default.
• W3124932017 cites W3015841865 @default.
• W3124932017 cites W3034521003 @default.
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• W3124932017 doi "https://doi.org/10.1016/j.jsbmb.2021.105827" @default.
• W3124932017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33497793" @default.
• W3124932017 hasPublicationYear "2021" @default.
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