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- W3124952119 abstract "Mycobacterium tuberculosis (MTB) infection is characterized by granulomatous lung lesions and systemic inflammatory responses during active disease. Inflammasome activation is involved in regulation of inflammation. Inflammasomes are multiprotein complexes serving a platform for activation of caspase-1, which cleaves the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 into their active forms. These cytokines play an essential role in MTB control. MTB infection triggers activation of the nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes in vitro, but only AIM2 and apoptosis-associated speck-like protein containing a caspase-activation recruitment domain (ASC), rather than NLRP3 or caspase-1, favor host survival and restriction of mycobacterial replication in vivo. Interferons (IFNs) inhibits MTB-induced inflammasome activation and IL-1 signaling. In this review, we focus on activation and regulation of the NLRP3 and AIM2 inflammasomes after exposure to MTB, as well as the effect of inflammasome activation on host defense against the infection." @default.
- W3124952119 created "2021-02-01" @default.
- W3124952119 creator A5001829459 @default.
- W3124952119 creator A5014333401 @default.
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- W3124952119 creator A5043044863 @default.
- W3124952119 creator A5049264654 @default.
- W3124952119 creator A5080125836 @default.
- W3124952119 date "2021-01-25" @default.
- W3124952119 modified "2023-10-13" @default.
- W3124952119 title "The Roles of Inflammasomes in Host Defense against Mycobacterium tuberculosis" @default.
- W3124952119 cites W1489330398 @default.
- W3124952119 cites W1501181174 @default.
- W3124952119 cites W1533217355 @default.
- W3124952119 cites W1543052543 @default.
- W3124952119 cites W1551561822 @default.
- W3124952119 cites W1552410459 @default.
- W3124952119 cites W1563133958 @default.
- W3124952119 cites W1615829672 @default.
- W3124952119 cites W1667606852 @default.
- W3124952119 cites W1756750202 @default.
- W3124952119 cites W1837402067 @default.
- W3124952119 cites W1842407033 @default.
- W3124952119 cites W1896675849 @default.
- W3124952119 cites W1897605380 @default.
- W3124952119 cites W1940294549 @default.
- W3124952119 cites W1964253344 @default.
- W3124952119 cites W1965390251 @default.
- W3124952119 cites W1965769177 @default.
- W3124952119 cites W1966829374 @default.
- W3124952119 cites W1967139098 @default.
- W3124952119 cites W1967784427 @default.
- W3124952119 cites W1969019747 @default.
- W3124952119 cites W1971244052 @default.
- W3124952119 cites W1973720948 @default.
- W3124952119 cites W1974412717 @default.
- W3124952119 cites W1978007043 @default.
- W3124952119 cites W1978516910 @default.
- W3124952119 cites W1979677164 @default.
- W3124952119 cites W1984355221 @default.
- W3124952119 cites W1985779248 @default.
- W3124952119 cites W1986648174 @default.
- W3124952119 cites W1992799735 @default.
- W3124952119 cites W1993340666 @default.
- W3124952119 cites W1996691476 @default.
- W3124952119 cites W1998055077 @default.
- W3124952119 cites W2000765205 @default.
- W3124952119 cites W2001856777 @default.
- W3124952119 cites W2002175938 @default.
- W3124952119 cites W2007432455 @default.
- W3124952119 cites W2008643985 @default.
- W3124952119 cites W2008742439 @default.
- W3124952119 cites W2010146052 @default.
- W3124952119 cites W2015263036 @default.
- W3124952119 cites W2016512909 @default.
- W3124952119 cites W2017883909 @default.
- W3124952119 cites W2018563185 @default.
- W3124952119 cites W2023478821 @default.
- W3124952119 cites W2024919703 @default.
- W3124952119 cites W2027562913 @default.
- W3124952119 cites W2029717255 @default.
- W3124952119 cites W2033236322 @default.
- W3124952119 cites W2034615108 @default.
- W3124952119 cites W2034831207 @default.
- W3124952119 cites W2035630729 @default.
- W3124952119 cites W2040289165 @default.
- W3124952119 cites W2041088729 @default.
- W3124952119 cites W2041352944 @default.
- W3124952119 cites W2042288276 @default.
- W3124952119 cites W2042816890 @default.
- W3124952119 cites W2043823247 @default.
- W3124952119 cites W2051792510 @default.
- W3124952119 cites W2052571878 @default.
- W3124952119 cites W2052791500 @default.
- W3124952119 cites W2053429123 @default.
- W3124952119 cites W2055727949 @default.
- W3124952119 cites W2061957280 @default.
- W3124952119 cites W2065217848 @default.
- W3124952119 cites W2067406680 @default.
- W3124952119 cites W2067776060 @default.
- W3124952119 cites W2068419165 @default.
- W3124952119 cites W2071889908 @default.
- W3124952119 cites W2072277765 @default.
- W3124952119 cites W2079484449 @default.
- W3124952119 cites W2081286173 @default.
- W3124952119 cites W2089938437 @default.
- W3124952119 cites W2090697934 @default.
- W3124952119 cites W2091229884 @default.
- W3124952119 cites W2091318049 @default.
- W3124952119 cites W2092713838 @default.
- W3124952119 cites W2093403863 @default.
- W3124952119 cites W2093539486 @default.
- W3124952119 cites W2094746130 @default.
- W3124952119 cites W2096558846 @default.
- W3124952119 cites W2096569856 @default.
- W3124952119 cites W2102806888 @default.
- W3124952119 cites W2102888433 @default.