Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124965034> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3124965034 abstract "Understanding which phenotypes are accessible from which genotypes is fundamental for understanding the evolutionary process. This notion of accessibility can be used to define a relation of nearness among phenotypes, independently of their similarity. Because of neutrality, phenotypes denote equivalence classes of genotypes. The definition of neighborhood relations among phenotypes relies, therefore, on the statistics of neighborhood relations among equivalence classes of genotypes in genotype space. The folding of RNA sequences (genotypes) into secondary structures (phenotypes) is an ideal case to implement these concepts. We study the extent to which the folding of RNA sequences induces a ``statistical topology'' on the set of minimum free energy secondary structures. The resulting nearness relation suggests a notion of ``continuous'' structure transformation. We can, then, rationalize major transitions in evolutionary trajectories at the level of RNA structures by identifying those transformations which are irreducibly discontinuous. This is shown by means of computer simulations. The statistical topology organizing the set of RNA shapes explains why neutral drift in sequence space plays a key role in evolutionary optimization." @default.
- W3124965034 created "2021-02-01" @default.
- W3124965034 creator A5001129387 @default.
- W3124965034 creator A5067812040 @default.
- W3124965034 date "1998-02-01" @default.
- W3124965034 modified "2023-09-27" @default.
- W3124965034 title "Shaping Space: The Possible and the Attainable in RNA Genotype-Phenotype Mapping" @default.
- W3124965034 hasPublicationYear "1998" @default.
- W3124965034 type Work @default.
- W3124965034 sameAs 3124965034 @default.
- W3124965034 citedByCount "0" @default.
- W3124965034 crossrefType "posted-content" @default.
- W3124965034 hasAuthorship W3124965034A5001129387 @default.
- W3124965034 hasAuthorship W3124965034A5067812040 @default.
- W3124965034 hasConcept C114614502 @default.
- W3124965034 hasConcept C132954091 @default.
- W3124965034 hasConcept C156103551 @default.
- W3124965034 hasConcept C177264268 @default.
- W3124965034 hasConcept C184720557 @default.
- W3124965034 hasConcept C199360897 @default.
- W3124965034 hasConcept C202444582 @default.
- W3124965034 hasConcept C2780069185 @default.
- W3124965034 hasConcept C30711495 @default.
- W3124965034 hasConcept C33923547 @default.
- W3124965034 hasConcept C41008148 @default.
- W3124965034 hasConcept C70721500 @default.
- W3124965034 hasConcept C80444323 @default.
- W3124965034 hasConcept C86803240 @default.
- W3124965034 hasConceptScore W3124965034C114614502 @default.
- W3124965034 hasConceptScore W3124965034C132954091 @default.
- W3124965034 hasConceptScore W3124965034C156103551 @default.
- W3124965034 hasConceptScore W3124965034C177264268 @default.
- W3124965034 hasConceptScore W3124965034C184720557 @default.
- W3124965034 hasConceptScore W3124965034C199360897 @default.
- W3124965034 hasConceptScore W3124965034C202444582 @default.
- W3124965034 hasConceptScore W3124965034C2780069185 @default.
- W3124965034 hasConceptScore W3124965034C30711495 @default.
- W3124965034 hasConceptScore W3124965034C33923547 @default.
- W3124965034 hasConceptScore W3124965034C41008148 @default.
- W3124965034 hasConceptScore W3124965034C70721500 @default.
- W3124965034 hasConceptScore W3124965034C80444323 @default.
- W3124965034 hasConceptScore W3124965034C86803240 @default.
- W3124965034 hasLocation W31249650341 @default.
- W3124965034 hasOpenAccess W3124965034 @default.
- W3124965034 hasPrimaryLocation W31249650341 @default.
- W3124965034 hasRelatedWork W1549237449 @default.
- W3124965034 hasRelatedWork W1684052628 @default.
- W3124965034 hasRelatedWork W1981542950 @default.
- W3124965034 hasRelatedWork W1989841732 @default.
- W3124965034 hasRelatedWork W2033952757 @default.
- W3124965034 hasRelatedWork W2043971857 @default.
- W3124965034 hasRelatedWork W2052214482 @default.
- W3124965034 hasRelatedWork W2059557910 @default.
- W3124965034 hasRelatedWork W2109326795 @default.
- W3124965034 hasRelatedWork W2218828295 @default.
- W3124965034 hasRelatedWork W2238770515 @default.
- W3124965034 hasRelatedWork W2511170192 @default.
- W3124965034 hasRelatedWork W2950268122 @default.
- W3124965034 hasRelatedWork W3105540032 @default.
- W3124965034 hasRelatedWork W3121909646 @default.
- W3124965034 hasRelatedWork W3125950950 @default.
- W3124965034 hasRelatedWork W3126135469 @default.
- W3124965034 hasRelatedWork W35191114 @default.
- W3124965034 hasRelatedWork W74038344 @default.
- W3124965034 hasRelatedWork W1862470060 @default.
- W3124965034 isParatext "false" @default.
- W3124965034 isRetracted "false" @default.
- W3124965034 magId "3124965034" @default.
- W3124965034 workType "article" @default.