FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W312497926> ?p ?o ?g. }

• W312497926 endingPage "8" @default.
• W312497926 startingPage "551" @default.
• W312497926 abstract "The anti-P. falciparum sporozoite vaccine consisting of the synthetic peptide, Ac-Cys-(NANP)3, conjugated to the protein tetanus toxoid (TT), [Ac-Cys-(NANP)3]25-TT, is currently undergoing human trials. The purpose of the present study was to assess various immunological parameters of this vaccine in mice, which have practical implications in humans. Two injections of [Ac-Cys-(NANP)3]25-TT adsorbed to Al(OH)3 were required to elicit a high antibody response against both Ac-Cys-(NANP)3 and TT. The vaccine initiated equivalent Ac-Cys-(NANP)3 priming for a secondary IgG response in 1-week-old and adult mice. Immunization of female mice with TT or [Ac-Cys-(NANP)3]23-TT prior to mating resulted in offspring that passively received anti-Ac-Cys-(NANP)3 and/or anti-TT antibody and that had reduced secondary responses to Ac-Cys-(NANP)3 and TT. Tertiary challenge with vaccine could substantially overcome such inhibition. Preimmunization of adult mice with TT resulted in a specific inhibition of the anti-Ac-Cys-(NANP)3 antibody response that disappeared following tertiary challenge with the vaccine. The conjugate initiated an antibody response against Ac-Cys-(NANP)3 and TT in mice of 16 different genotypes; only very low T-cell proliferative responses to (NANP)3 were observed for some of these strains. Mice injected with (NANP)3 coupled to protein demonstrated a secondary response to Ac-Cys-(NANP)3 when challenged with (NANP)3 on a heterologous carrier, indicating that B-cell priming alone may be sufficient for a secondary antibody response. These results demonstrate that the vaccine has favourable and unfavourable characteristics in mice; the potential for both exists in humans." @default.
• W312497926 created "2016-06-24" @default.
• W312497926 creator A5035468085 @default.
• W312497926 creator A5038251611 @default.
• W312497926 creator A5045229986 @default.
• W312497926 creator A5050410237 @default.
• W312497926 creator A5070268220 @default.
• W312497926 date "1988-07-01" @default.
• W312497926 modified "2023-10-18" @default.
• W312497926 title "Assessment in mice of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, P. falciparum." @default.
• W312497926 cites W1602294030 @default.
• W312497926 cites W1634845148 @default.
• W312497926 cites W1658245484 @default.
• W312497926 cites W1781631981 @default.
• W312497926 cites W1785244322 @default.
• W312497926 cites W1969138884 @default.
• W312497926 cites W1991676798 @default.
• W312497926 cites W1991766005 @default.
• W312497926 cites W1992999474 @default.
• W312497926 cites W1995297054 @default.
• W312497926 cites W2002568336 @default.
• W312497926 cites W2005944558 @default.
• W312497926 cites W2006592829 @default.
• W312497926 cites W2012381566 @default.
• W312497926 cites W2018549076 @default.
• W312497926 cites W2019752820 @default.
• W312497926 cites W2033090330 @default.
• W312497926 cites W2063122125 @default.
• W312497926 cites W2074407786 @default.
• W312497926 cites W2074459264 @default.
• W312497926 cites W2077685056 @default.
• W312497926 cites W2080477691 @default.
• W312497926 cites W2095369948 @default.
• W312497926 cites W2097979520 @default.
• W312497926 cites W2120000058 @default.
• W312497926 cites W2135620943 @default.
• W312497926 cites W2159845643 @default.
• W312497926 cites W2162472008 @default.
• W312497926 cites W2289400617 @default.
• W312497926 cites W2411408574 @default.
• W312497926 cites W316627930 @default.
• W312497926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1385072" @default.
• W312497926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3044983" @default.
• W312497926 hasPublicationYear "1988" @default.
• W312497926 type Work @default.
• W312497926 sameAs 312497926 @default.
• W312497926 citedByCount "4" @default.
• W312497926 countsByYear W3124979262022 @default.
• W312497926 crossrefType "journal-article" @default.
• W312497926 hasAuthorship W312497926A5035468085 @default.
• W312497926 hasAuthorship W312497926A5038251611 @default.
• W312497926 hasAuthorship W312497926A5045229986 @default.
• W312497926 hasAuthorship W312497926A5050410237 @default.
• W312497926 hasAuthorship W312497926A5070268220 @default.
• W312497926 hasConcept C100701293 @default.
• W312497926 hasConcept C159047783 @default.
• W312497926 hasConcept C159654299 @default.
• W312497926 hasConcept C203014093 @default.
• W312497926 hasConcept C22070199 @default.
• W312497926 hasConcept C2777351567 @default.
• W312497926 hasConcept C2779841045 @default.
• W312497926 hasConcept C2780801004 @default.
• W312497926 hasConcept C2780868878 @default.
• W312497926 hasConcept C59822182 @default.
• W312497926 hasConcept C81444415 @default.
• W312497926 hasConcept C86803240 @default.
• W312497926 hasConceptScore W312497926C100701293 @default.
• W312497926 hasConceptScore W312497926C159047783 @default.
• W312497926 hasConceptScore W312497926C159654299 @default.
• W312497926 hasConceptScore W312497926C203014093 @default.
• W312497926 hasConceptScore W312497926C22070199 @default.
• W312497926 hasConceptScore W312497926C2777351567 @default.
• W312497926 hasConceptScore W312497926C2779841045 @default.
• W312497926 hasConceptScore W312497926C2780801004 @default.
• W312497926 hasConceptScore W312497926C2780868878 @default.
• W312497926 hasConceptScore W312497926C59822182 @default.
• W312497926 hasConceptScore W312497926C81444415 @default.
• W312497926 hasConceptScore W312497926C86803240 @default.
• W312497926 hasIssue "3" @default.
• W312497926 hasLocation W3124979261 @default.
• W312497926 hasOpenAccess W312497926 @default.
• W312497926 hasPrimaryLocation W3124979261 @default.
• W312497926 hasRelatedWork W1628283138 @default.
• W312497926 hasRelatedWork W1987139724 @default.
• W312497926 hasRelatedWork W2024226059 @default.
• W312497926 hasRelatedWork W2072107399 @default.
• W312497926 hasRelatedWork W2076935057 @default.
• W312497926 hasRelatedWork W2100407330 @default.
• W312497926 hasRelatedWork W2397974850 @default.
• W312497926 hasRelatedWork W2398075918 @default.
• W312497926 hasRelatedWork W2564614797 @default.
• W312497926 hasRelatedWork W3022614672 @default.
• W312497926 hasVolume "64" @default.
• W312497926 isParatext "false" @default.
• W312497926 isRetracted "false" @default.
• W312497926 magId "312497926" @default.
• W312497926 workType "article" @default.