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- W3124998766 abstract "Chronic pouchitis may afflict up to 10% of patients with ulcerative colitis (UC) after total proctocolectomy and ileal pouch-anal anastomosis (IPAA).1 Intestinal dysbiosis after IPAA has been implicated in the pathogenesis of pouchitis, as patients often respond to probiotic and antibiotic therapy.2, 3 However, those who develop chronic pouchitis require frequent or continuous antibiotics to control symptoms of stool frequency, urgency, abdominal cramping, and hematochezia. The most severe cases are refractory to antibiotics and require biologic agents or pouch excision with permanent ileostomy. Fecal microbiota transplant (FMT), while only allowed clinically for the treatment of recurrent Clostridioides difficile infection (CDI) under the Food and Drug Administration’s policy of enforcement discretion in the United States, has shown benefit in the treatment of UC compared with placebo in 3 of 4 randomized trials, with an associated increase in microbial diversity.4, 5 Given the microbial basis for the..." @default.
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- W3124998766 date "2021-01-27" @default.
- W3124998766 modified "2023-09-27" @default.
- W3124998766 title "Fecal Microbiota Transplantation for Chronic Pouchitis: Promising Novel Therapeutic or Lost Cause?" @default.
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- W3124998766 doi "https://doi.org/10.1093/ibd/izab002" @default.
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