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• W3125048266 abstract "Pathogen-associated molecular patterns activate the immune system via pattern recognition receptors. Recently, newly discovered pathogen-associated molecular patterns, d-glycero-β-d-mannoheptose phosphate and d-glycero-β-d-mannoheptose 1,7-biphosphate, were shown to induce a TRAF-interacting protein with a forkhead-associated domain-dependent immune response in human embryonic kidney cells and colonic epithelial cells. Concurrently, ADP-heptose was shown to bind α-kinase 1 and activate TIFA via phosphorylation leading to an immune cascade to ultimately activate NF-κB. These pathogen-associated molecular patterns have raised interest in the pharmaceutical industry for their potential use as immunomodulators. However, little is understood about the host cell uptake of d-glycero-β-d-mannoheptose phosphate, d-glycero-β-d-mannoheptose 1,7-biphosphate, and ADP-heptose in vivo and derivatives of these molecules are needed to interrogate this. In this regard, herein we describe 7-O-modifications of d-glycero-β-d-mannoheptose phosphate to produce molecular probes toward the development of a useful toolbox for biologists. A convergent strategy that involves introduction of a substituent at O-7 before alkene oxidation was investigated and proved successful in the generation of a range of molecular probes." @default.
• W3125048266 created "2021-02-01" @default.
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• W3125048266 date "2021-01-15" @default.
• W3125048266 modified "2023-09-27" @default.
• W3125048266 title "<scp>d</scp>-<i>Glycero</i>-β-<scp>d</scp>-<i>manno</i>heptose Phosphate 7-<i>O</i>-Modifications" @default.
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• W3125048266 doi "https://doi.org/10.1021/acs.joc.0c02333" @default.
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