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- W3125064248 endingPage "111997" @default.
- W3125064248 startingPage "111997" @default.
- W3125064248 abstract "Chronic inflammation is crucial for the pathological process of tumors due to increasing the infiltration of cytokines, growth factors, and chemokines to the tumor microenvironment. Phenolic compounds are considered natural remedies for inflammation and cancer. Mangiferin is a C-glycosyl xanthone that possesses numerous pharmacological activities. It has the potential to attenuate inflammation in different organs through the mechanisms of inhibiting pattern recognition receptors, regulating cell signaling pathways, activating autophagy, inhibiting the secretion of inflammatory mediators, and protecting intestinal barrier integrity, which in turn prevents cancer. In this review, the recent advances in the anti-inflammation and anti-cancer mechanisms of mangiferin as well as its safety and toxicity were summarized. The impacts of modified mangiferin and the synergic effects with other components were also discussed. Understanding the molecular targets of mangiferin is of great significance for its better application in the amelioration of inflammation-related diseases. • Mangiferin has the potential to attenuate inflammation in different organs. • Mangiferin regulates receptors, cell signalings, and cytokines. • Mangiferin activates autophagy and protects intestinal barrier integrity. • Mangiferin shows potential therapeutic capability for inflammation-related cancer. • A dose of mangiferin less than 2 g/kg BW/day is generally considered safe." @default.
- W3125064248 created "2021-02-01" @default.
- W3125064248 creator A5081780038 @default.
- W3125064248 creator A5082079711 @default.
- W3125064248 creator A5086503871 @default.
- W3125064248 date "2021-03-01" @default.
- W3125064248 modified "2023-10-11" @default.
- W3125064248 title "Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms" @default.
- W3125064248 cites W1541540076 @default.
- W3125064248 cites W1702179723 @default.
- W3125064248 cites W1911483769 @default.
- W3125064248 cites W1952394616 @default.
- W3125064248 cites W1991328746 @default.
- W3125064248 cites W1997597510 @default.
- W3125064248 cites W2005805356 @default.
- W3125064248 cites W2009497505 @default.
- W3125064248 cites W2015336843 @default.
- W3125064248 cites W2024381556 @default.
- W3125064248 cites W2031084334 @default.
- W3125064248 cites W2031986590 @default.
- W3125064248 cites W2034402249 @default.
- W3125064248 cites W2038906350 @default.
- W3125064248 cites W2042433863 @default.
- W3125064248 cites W2061768810 @default.
- W3125064248 cites W2080356646 @default.
- W3125064248 cites W2082629846 @default.
- W3125064248 cites W2085014260 @default.
- W3125064248 cites W2094506874 @default.
- W3125064248 cites W2099951919 @default.
- W3125064248 cites W2100035590 @default.
- W3125064248 cites W2144189273 @default.
- W3125064248 cites W2173871950 @default.
- W3125064248 cites W2183120901 @default.
- W3125064248 cites W2278016680 @default.
- W3125064248 cites W2282580521 @default.
- W3125064248 cites W2292995640 @default.
- W3125064248 cites W2298525657 @default.
- W3125064248 cites W2301478078 @default.
- W3125064248 cites W2329172048 @default.
- W3125064248 cites W2344222630 @default.
- W3125064248 cites W2399810943 @default.
- W3125064248 cites W2405052429 @default.
- W3125064248 cites W2409212671 @default.
- W3125064248 cites W2410865333 @default.
- W3125064248 cites W2428968292 @default.
- W3125064248 cites W2470164054 @default.
- W3125064248 cites W2475765940 @default.
- W3125064248 cites W2486949243 @default.
- W3125064248 cites W2506148354 @default.
- W3125064248 cites W2513932865 @default.
- W3125064248 cites W2515199119 @default.
- W3125064248 cites W2520951105 @default.
- W3125064248 cites W2526946522 @default.
- W3125064248 cites W2531849773 @default.
- W3125064248 cites W2535932582 @default.
- W3125064248 cites W2544538458 @default.
- W3125064248 cites W2551146842 @default.
- W3125064248 cites W2562641013 @default.
- W3125064248 cites W2563782583 @default.
- W3125064248 cites W2590125666 @default.
- W3125064248 cites W2591036296 @default.
- W3125064248 cites W2598560533 @default.
- W3125064248 cites W2599614749 @default.
- W3125064248 cites W2605817542 @default.
- W3125064248 cites W2608155315 @default.
- W3125064248 cites W2613535326 @default.
- W3125064248 cites W2623247885 @default.
- W3125064248 cites W2651958066 @default.
- W3125064248 cites W2734834192 @default.
- W3125064248 cites W2735513656 @default.
- W3125064248 cites W2754053556 @default.
- W3125064248 cites W2763304713 @default.
- W3125064248 cites W2765533007 @default.
- W3125064248 cites W2769259997 @default.
- W3125064248 cites W2769811155 @default.
- W3125064248 cites W2771451409 @default.
- W3125064248 cites W2772813323 @default.
- W3125064248 cites W2779116051 @default.
- W3125064248 cites W2788317308 @default.
- W3125064248 cites W2789938235 @default.
- W3125064248 cites W2791295577 @default.
- W3125064248 cites W2799473901 @default.
- W3125064248 cites W2800375422 @default.
- W3125064248 cites W2800620450 @default.
- W3125064248 cites W2802982036 @default.
- W3125064248 cites W2805181577 @default.
- W3125064248 cites W2806361510 @default.
- W3125064248 cites W2809650806 @default.
- W3125064248 cites W2809913030 @default.
- W3125064248 cites W2810936867 @default.
- W3125064248 cites W2856307204 @default.
- W3125064248 cites W2884126108 @default.
- W3125064248 cites W2884445384 @default.
- W3125064248 cites W2885093728 @default.
- W3125064248 cites W2885273732 @default.
- W3125064248 cites W2887239928 @default.
- W3125064248 cites W2890187387 @default.
- W3125064248 cites W2898270830 @default.