Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125092178> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3125092178 abstract "This research sought to study the influence and potentialmechanism of paeoniflorin and albiflorin on strychnine and brucine transport in MDCK-MDR1 cells regulated by P-gp. Cytotoxicity of drugs was tested by MTT assay, and the transport studies were performed in both directions in MDCK-MDR1 cells. The influence of drugs on P-gp ATPase, and the efflux function of P-gp, the expression levels of P-gp and MDR1 mRNA were also estimated. Strychnine and brucine showed well absorption, and the main transport mechanism might be passive diffusion. Verapamil could significantly decrease the efflux rate (ER) of strychnine and brucine, while the ER of strychnine and brucine was increased significantly when co-administrated with paeoniflorin or albiflorin, indicating that paeoniflorin and albiflorin could promote the efflux of these two alkaloids. Strychnine and brucine could activate the activity of P-gp ATPase, suppress the efflux function of P-gp, but have no significant effect on the expression of P-gp. In addition, strychnine could upregulate the expression of MDR1 mRNA. Paeoniflorin and albiflorin could increase the transmembrane transport of strychnine and brucine mediated by P-gp when co-administrated with strychnine or brucine via stimulating the activity of P-gp ATPase, enhancing the efflux function of P-g, increasing the expression levels of MDR1 mRNA and P-gp." @default.
- W3125092178 created "2021-02-01" @default.
- W3125092178 creator A5003379845 @default.
- W3125092178 creator A5003501484 @default.
- W3125092178 creator A5022888334 @default.
- W3125092178 creator A5024712945 @default.
- W3125092178 creator A5055810182 @default.
- W3125092178 creator A5063005161 @default.
- W3125092178 date "2020-10-01" @default.
- W3125092178 modified "2023-10-15" @default.
- W3125092178 title "The Influence and Mechanism of Paeoniflorin and Albiflorin on Strychnine and Brucine Transport Through Madin-Darby Canine Kidney/Multidrug Resistance1 Cells In Vitro Model" @default.
- W3125092178 doi "https://doi.org/10.1166/jbmb.2020.1998" @default.
- W3125092178 hasPublicationYear "2020" @default.
- W3125092178 type Work @default.
- W3125092178 sameAs 3125092178 @default.
- W3125092178 citedByCount "0" @default.
- W3125092178 crossrefType "journal-article" @default.
- W3125092178 hasAuthorship W3125092178A5003379845 @default.
- W3125092178 hasAuthorship W3125092178A5003501484 @default.
- W3125092178 hasAuthorship W3125092178A5022888334 @default.
- W3125092178 hasAuthorship W3125092178A5024712945 @default.
- W3125092178 hasAuthorship W3125092178A5055810182 @default.
- W3125092178 hasAuthorship W3125092178A5063005161 @default.
- W3125092178 hasConcept C104317684 @default.
- W3125092178 hasConcept C149011108 @default.
- W3125092178 hasConcept C179998833 @default.
- W3125092178 hasConcept C185592680 @default.
- W3125092178 hasConcept C200082930 @default.
- W3125092178 hasConcept C2776918747 @default.
- W3125092178 hasConcept C2777725853 @default.
- W3125092178 hasConcept C2780536827 @default.
- W3125092178 hasConcept C2780813057 @default.
- W3125092178 hasConcept C43617362 @default.
- W3125092178 hasConcept C55493867 @default.
- W3125092178 hasConcept C86803240 @default.
- W3125092178 hasConcept C98274493 @default.
- W3125092178 hasConceptScore W3125092178C104317684 @default.
- W3125092178 hasConceptScore W3125092178C149011108 @default.
- W3125092178 hasConceptScore W3125092178C179998833 @default.
- W3125092178 hasConceptScore W3125092178C185592680 @default.
- W3125092178 hasConceptScore W3125092178C200082930 @default.
- W3125092178 hasConceptScore W3125092178C2776918747 @default.
- W3125092178 hasConceptScore W3125092178C2777725853 @default.
- W3125092178 hasConceptScore W3125092178C2780536827 @default.
- W3125092178 hasConceptScore W3125092178C2780813057 @default.
- W3125092178 hasConceptScore W3125092178C43617362 @default.
- W3125092178 hasConceptScore W3125092178C55493867 @default.
- W3125092178 hasConceptScore W3125092178C86803240 @default.
- W3125092178 hasConceptScore W3125092178C98274493 @default.
- W3125092178 hasLocation W31250921781 @default.
- W3125092178 hasOpenAccess W3125092178 @default.
- W3125092178 hasPrimaryLocation W31250921781 @default.
- W3125092178 hasRelatedWork W10899817 @default.
- W3125092178 hasRelatedWork W2223006 @default.
- W3125092178 hasRelatedWork W24588434 @default.
- W3125092178 hasRelatedWork W25995060 @default.
- W3125092178 hasRelatedWork W27258246 @default.
- W3125092178 hasRelatedWork W30248127 @default.
- W3125092178 hasRelatedWork W32628894 @default.
- W3125092178 hasRelatedWork W34156799 @default.
- W3125092178 hasRelatedWork W4772137 @default.
- W3125092178 hasRelatedWork W6273245 @default.
- W3125092178 isParatext "false" @default.
- W3125092178 isRetracted "false" @default.
- W3125092178 magId "3125092178" @default.
- W3125092178 workType "article" @default.