FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125103697> ?p ?o ?g. }

• W3125103697 endingPage "28" @default.
• W3125103697 startingPage "23" @default.
• W3125103697 abstract "The mechanical force of blood flow is a fundamental determinant of vascular homeostasis. This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as being essential to placental development and function. Here, we focus on the role of FSS in regulating fetoplacental circulatory flow, both in normal pregnancy and that affected by fetal growth restriction (FGR). The fetus is reliant on placental perfusion to meet its circulatory and metabolic demands. Failure of normal vascular adaptation and the mechanisms enabling responsive interaction between fetoplacental and maternal circulations can result in FGR. FSS generates vasodilatation at least partly through the release of endothelial nitric oxide, a process thought to be vital for adequate blood flow. Where FGR is caused by placental dysfunction, placental vascular anatomy is altered, alongside endothelial dysfunction and hypoxia, each impacting upon the complex balance of FSS forces. Identifying specific mechanical sensors and the mechanisms governing how FSS force is converted into biochemical signals is a fast-paced area of research. Here, we raise awareness of Piezo1 proteins, recently discovered to be FSS-sensitive in fetoplacental endothelium, and with emerging roles in NO generation, vascular tone and angiogenesis. We discuss the emerging concept that activating mechanosensors such as Piezo1 ultimately results in the orchestrated processes of placental vascular adaptation. Piecing together the mechanisms governing endothelial responses to FSS in placental insufficiency is an important step towards developing new treatments for FGR." @default.
• W3125103697 created "2021-02-01" @default.
• W3125103697 creator A5000992391 @default.
• W3125103697 creator A5006167520 @default.
• W3125103697 creator A5027312074 @default.
• W3125103697 creator A5050588172 @default.
• W3125103697 creator A5067903035 @default.
• W3125103697 date "2021-09-01" @default.
• W3125103697 modified "2023-10-17" @default.
• W3125103697 title "Placental blood flow sensing and regulation in fetal growth restriction" @default.
• W3125103697 cites W1550707014 @default.
• W3125103697 cites W1581668752 @default.
• W3125103697 cites W1914868353 @default.
• W3125103697 cites W1979071912 @default.
• W3125103697 cites W1983897833 @default.
• W3125103697 cites W1988321289 @default.
• W3125103697 cites W1991643569 @default.
• W3125103697 cites W1992792350 @default.
• W3125103697 cites W1993794913 @default.
• W3125103697 cites W2003213503 @default.
• W3125103697 cites W2018466264 @default.
• W3125103697 cites W2025848071 @default.
• W3125103697 cites W2030107038 @default.
• W3125103697 cites W2041034845 @default.
• W3125103697 cites W2068921512 @default.
• W3125103697 cites W2070665466 @default.
• W3125103697 cites W2084099835 @default.
• W3125103697 cites W2095565236 @default.
• W3125103697 cites W2095759493 @default.
• W3125103697 cites W2100842913 @default.
• W3125103697 cites W2101005553 @default.
• W3125103697 cites W2111352614 @default.
• W3125103697 cites W2116145833 @default.
• W3125103697 cites W2116833507 @default.
• W3125103697 cites W2127461430 @default.
• W3125103697 cites W2149091090 @default.
• W3125103697 cites W2151927310 @default.
• W3125103697 cites W2154712507 @default.
• W3125103697 cites W2161020445 @default.
• W3125103697 cites W2167052889 @default.
• W3125103697 cites W2356785084 @default.
• W3125103697 cites W2396404851 @default.
• W3125103697 cites W2492287082 @default.
• W3125103697 cites W2519262228 @default.
• W3125103697 cites W2542750476 @default.
• W3125103697 cites W2567670768 @default.
• W3125103697 cites W2592385138 @default.
• W3125103697 cites W2768467254 @default.
• W3125103697 cites W2772417060 @default.
• W3125103697 cites W2779962245 @default.
• W3125103697 cites W2790251179 @default.
• W3125103697 cites W2793971933 @default.
• W3125103697 cites W2803038140 @default.
• W3125103697 cites W2886094490 @default.
• W3125103697 cites W2886224776 @default.
• W3125103697 cites W2888921562 @default.
• W3125103697 cites W2928471418 @default.
• W3125103697 cites W2960665032 @default.
• W3125103697 cites W2973598194 @default.
• W3125103697 cites W2975355175 @default.
• W3125103697 cites W3008164084 @default.
• W3125103697 cites W3014610410 @default.
• W3125103697 cites W3014739956 @default.
• W3125103697 cites W3047139909 @default.
• W3125103697 cites W3047886196 @default.
• W3125103697 cites W3089844102 @default.
• W3125103697 cites W45499648 @default.
• W3125103697 cites W2085175448 @default.
• W3125103697 doi "https://doi.org/10.1016/j.placenta.2021.01.007" @default.
• W3125103697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8448138" @default.
• W3125103697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33509641" @default.
• W3125103697 hasPublicationYear "2021" @default.
• W3125103697 type Work @default.
• W3125103697 sameAs 3125103697 @default.
• W3125103697 citedByCount "8" @default.
• W3125103697 countsByYear W31251036972021 @default.
• W3125103697 countsByYear W31251036972022 @default.
• W3125103697 countsByYear W31251036972023 @default.
• W3125103697 crossrefType "journal-article" @default.
• W3125103697 hasAuthorship W3125103697A5000992391 @default.
• W3125103697 hasAuthorship W3125103697A5006167520 @default.
• W3125103697 hasAuthorship W3125103697A5027312074 @default.
• W3125103697 hasAuthorship W3125103697A5050588172 @default.
• W3125103697 hasAuthorship W3125103697A5067903035 @default.
• W3125103697 hasBestOaLocation W31251036971 @default.
• W3125103697 hasConcept C120770815 @default.
• W3125103697 hasConcept C126322002 @default.
• W3125103697 hasConcept C134018914 @default.
• W3125103697 hasConcept C158846371 @default.
• W3125103697 hasConcept C169760540 @default.
• W3125103697 hasConcept C172680121 @default.
• W3125103697 hasConcept C2776886772 @default.
• W3125103697 hasConcept C2776953305 @default.
• W3125103697 hasConcept C2776992346 @default.
• W3125103697 hasConcept C2779234561 @default.
• W3125103697 hasConcept C2780394083 @default.
• W3125103697 hasConcept C54355233 @default.
• W3125103697 hasConcept C71924100 @default.

• next