FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125144493> ?p ?o ?g. }

• W3125144493 abstract "Abstract Transcriptional regulation by Wnt signalling is primarily thought to be accomplished by a complex of β-catenin and TCF family transcription factors (TFs). Although numerous studies have suggested that additional TFs play roles in regulating Wnt target genes, their mechanisms of action have not been investigated in detail. We characterised a Wnt-responsive element (WRE) downstream of the Wnt target gene Axin2 and found that TCFs and Caudal-related homeodomain (CDX) proteins were required for its activation. Using a new separation-of-function TCF mutant, we found that WRE activity requires the formation of a TCF/CDX complex. Our systematic mutagenesis of this enhancer identified other sequences essential for activation by Wnt signalling, including several copies of a novel CAG DNA motif. Computational and experimental evidence indicates that the TCF/CDX/CAG mode of regulation is prevalent in multiple WREs. Put together, our results demonstrate the complex nature of cis- and trans- interactions required for signal-dependent enhancer activity." @default.
• W3125144493 created "2021-02-01" @default.
• W3125144493 creator A5032827654 @default.
• W3125144493 creator A5039136921 @default.
• W3125144493 creator A5039692681 @default.
• W3125144493 creator A5066840372 @default.
• W3125144493 date "2021-01-17" @default.
• W3125144493 modified "2023-09-23" @default.
• W3125144493 title "Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif" @default.
• W3125144493 cites W1598293541 @default.
• W3125144493 cites W1628437161 @default.
• W3125144493 cites W1956262850 @default.
• W3125144493 cites W1977632740 @default.
• W3125144493 cites W1977709885 @default.
• W3125144493 cites W1978826904 @default.
• W3125144493 cites W1981967310 @default.
• W3125144493 cites W1987122345 @default.
• W3125144493 cites W1987865998 @default.
• W3125144493 cites W1991460649 @default.
• W3125144493 cites W1996583924 @default.
• W3125144493 cites W1997767982 @default.
• W3125144493 cites W2001770641 @default.
• W3125144493 cites W2003778163 @default.
• W3125144493 cites W2006419043 @default.
• W3125144493 cites W2007771300 @default.
• W3125144493 cites W2008047506 @default.
• W3125144493 cites W2008557163 @default.
• W3125144493 cites W2017593144 @default.
• W3125144493 cites W2021654829 @default.
• W3125144493 cites W2022120062 @default.
• W3125144493 cites W2028326666 @default.
• W3125144493 cites W2038087401 @default.
• W3125144493 cites W2038206901 @default.
• W3125144493 cites W2045362835 @default.
• W3125144493 cites W2045984249 @default.
• W3125144493 cites W2050902755 @default.
• W3125144493 cites W2057629607 @default.
• W3125144493 cites W2066078074 @default.
• W3125144493 cites W2067109855 @default.
• W3125144493 cites W2080152736 @default.
• W3125144493 cites W2086876386 @default.
• W3125144493 cites W2096171021 @default.
• W3125144493 cites W2098188064 @default.
• W3125144493 cites W2100700900 @default.
• W3125144493 cites W2102512718 @default.
• W3125144493 cites W2102619694 @default.
• W3125144493 cites W2108244474 @default.
• W3125144493 cites W2109144433 @default.
• W3125144493 cites W2112517492 @default.
• W3125144493 cites W2116315632 @default.
• W3125144493 cites W2120662540 @default.
• W3125144493 cites W2122852240 @default.
• W3125144493 cites W2123187473 @default.
• W3125144493 cites W2123389364 @default.
• W3125144493 cites W2124017740 @default.
• W3125144493 cites W2127575026 @default.
• W3125144493 cites W2128016314 @default.
• W3125144493 cites W2140952049 @default.
• W3125144493 cites W2143625921 @default.
• W3125144493 cites W2144796426 @default.
• W3125144493 cites W2146167376 @default.
• W3125144493 cites W2147825409 @default.
• W3125144493 cites W2148070899 @default.
• W3125144493 cites W2152611630 @default.
• W3125144493 cites W2157009395 @default.
• W3125144493 cites W2160193499 @default.
• W3125144493 cites W2162295076 @default.
• W3125144493 cites W2164562289 @default.
• W3125144493 cites W2166310590 @default.
• W3125144493 cites W2166897005 @default.
• W3125144493 cites W2168272873 @default.
• W3125144493 cites W2171996338 @default.
• W3125144493 cites W2278320459 @default.
• W3125144493 cites W2293907333 @default.
• W3125144493 cites W2295352084 @default.
• W3125144493 cites W2345943684 @default.
• W3125144493 cites W2443986749 @default.
• W3125144493 cites W2524507363 @default.
• W3125144493 cites W2566241189 @default.
• W3125144493 cites W2570066480 @default.
• W3125144493 cites W2604477135 @default.
• W3125144493 cites W2617293027 @default.
• W3125144493 cites W2739924433 @default.
• W3125144493 cites W2752417195 @default.
• W3125144493 cites W2785792383 @default.
• W3125144493 cites W2803479625 @default.
• W3125144493 cites W2952452404 @default.
• W3125144493 cites W3056694453 @default.
• W3125144493 cites W3094105865 @default.
• W3125144493 cites W3094755456 @default.
• W3125144493 cites W4246359243 @default.
• W3125144493 doi "https://doi.org/10.1101/2021.01.15.426889" @default.
• W3125144493 hasPublicationYear "2021" @default.
• W3125144493 type Work @default.
• W3125144493 sameAs 3125144493 @default.
• W3125144493 citedByCount "0" @default.
• W3125144493 crossrefType "posted-content" @default.
• W3125144493 hasAuthorship W3125144493A5032827654 @default.
• W3125144493 hasAuthorship W3125144493A5039136921 @default.
• W3125144493 hasAuthorship W3125144493A5039692681 @default.

• next