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• W3125180129 endingPage "271" @default.
• W3125180129 startingPage "271" @default.
• W3125180129 abstract "The attachment of bacteria and other microbes to natural and artificial surfaces leads to the development of biofilms, which can further cause nosocomial infections. Thus, an important field of research is the development of new materials capable of preventing the initial adhesion of pathogenic microorganisms. In this work, novel polymer/particle composite materials, based on a polythiourethane (PTU) matrix and either spherical (s-ZnO) or tetrapodal (t-ZnO) shaped ZnO fillers, were developed and characterized with respect to their mechanical, chemical and surface properties. To then evaluate their potential as anti-fouling surfaces, the adhesion of two different pathogenic microorganism species, Staphylococcus aureus and Candida glabrata, was studied using atomic force microscopy (AFM). Our results show that the adhesion of both S. aureus and C. glabrata to PTU and PTU/ZnO is decreased compared to a model surface polydimethylsiloxane (PDMS). It was furthermore found that the amount of both s-ZnO and t-ZnO filler had a direct influence on the adhesion of S. aureus, as increasing amounts of ZnO particles resulted in reduced adhesion of the cells. For both microorganisms, material composites with 5 wt.% of t-ZnO particles showed the greatest potential for anti-fouling with significantly decreased adhesion of cells. Altogether, both pathogens exhibit a reduced capacity to adhere to the newly developed nanomaterials used in this study, thus showing their potential for bio-medical applications." @default.
• W3125180129 created "2021-02-01" @default.
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• W3125180129 date "2021-01-21" @default.
• W3125180129 modified "2023-09-30" @default.
• W3125180129 title "Development of Polythiourethane/ZnO-Based Anti-Fouling Materials and Evaluation of the Adhesion of Staphylococcus aureus and Candida glabrata Using Single-Cell Force Spectroscopy" @default.
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• W3125180129 doi "https://doi.org/10.3390/nano11020271" @default.
• W3125180129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7909824" @default.
• W3125180129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33494168" @default.
• W3125180129 hasPublicationYear "2021" @default.
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