FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125205308> ?p ?o ?g. }

• W3125205308 endingPage "67" @default.
• W3125205308 startingPage "55" @default.
• W3125205308 abstract "Objective Creeping fat, the wrapping of mesenteric fat around the bowel wall, is a typical feature of Crohn’s disease, and is associated with stricture formation and bowel obstruction. How creeping fat forms is unknown, and we interrogated potential mechanisms using novel intestinal tissue and cell interaction systems. Design Tissues from normal, UC, non-strictured and strictured Crohn’s disease intestinal specimens were obtained. The muscularis propria matrisome was determined via proteomics. Mesenteric fat explants, primary human preadipocytes and adipocytes were used in multiple ex vivo and in vitro cell migration systems on muscularis propria muscle cell derived or native extracellular matrix. Functional experiments included integrin characterisation via flow cytometry and their inhibition with specific blocking antibodies and chemicals. Results Crohn’s disease muscularis propria cells produced an extracellular matrix scaffold which is in direct spatial and functional contact with the immediately overlaid creeping fat. The scaffold contained multiple proteins, but only fibronectin production was singularly upregulated by transforming growth factor-β1. The muscle cell-derived matrix triggered migration of preadipocytes out of mesenteric fat, fibronectin being the dominant factor responsible for their migration. Blockade of α5β1 on the preadipocyte surface inhibited their migration out of mesenteric fat and on 3D decellularised intestinal tissue extracellular matrix. Conclusion Crohn’s disease creeping fat appears to result from the migration of preadipocytes out of mesenteric fat and differentiation into adipocytes in response to an increased production of fibronectin by activated muscularis propria cells. These new mechanistic insights may lead to novel approaches for prevention of creeping fat-associated stricture formation." @default.
• W3125205308 created "2021-02-01" @default.
• W3125205308 creator A5001254185 @default.
• W3125205308 creator A5003726335 @default.
• W3125205308 creator A5004785859 @default.
• W3125205308 creator A5005984287 @default.
• W3125205308 creator A5010057922 @default.
• W3125205308 creator A5012305407 @default.
• W3125205308 creator A5013764770 @default.
• W3125205308 creator A5036347175 @default.
• W3125205308 creator A5036764652 @default.
• W3125205308 creator A5043396915 @default.
• W3125205308 creator A5045134312 @default.
• W3125205308 creator A5049239234 @default.
• W3125205308 creator A5052443838 @default.
• W3125205308 creator A5055224390 @default.
• W3125205308 creator A5059698867 @default.
• W3125205308 creator A5067816171 @default.
• W3125205308 creator A5075877965 @default.
• W3125205308 creator A5076035375 @default.
• W3125205308 creator A5082271623 @default.
• W3125205308 creator A5091264218 @default.
• W3125205308 date "2021-01-19" @default.
• W3125205308 modified "2023-10-15" @default.
• W3125205308 title "Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn’s disease" @default.
• W3125205308 cites W149720224 @default.
• W3125205308 cites W1546880496 @default.
• W3125205308 cites W1761013599 @default.
• W3125205308 cites W1923800096 @default.
• W3125205308 cites W1973236001 @default.
• W3125205308 cites W1988156447 @default.
• W3125205308 cites W1989770537 @default.
• W3125205308 cites W2003574906 @default.
• W3125205308 cites W2007146069 @default.
• W3125205308 cites W2025371271 @default.
• W3125205308 cites W2025620210 @default.
• W3125205308 cites W2081931036 @default.
• W3125205308 cites W2085804112 @default.
• W3125205308 cites W2093478973 @default.
• W3125205308 cites W2106733239 @default.
• W3125205308 cites W2115416944 @default.
• W3125205308 cites W2119784105 @default.
• W3125205308 cites W2130922818 @default.
• W3125205308 cites W2131270144 @default.
• W3125205308 cites W2131495509 @default.
• W3125205308 cites W2134742663 @default.
• W3125205308 cites W2136965317 @default.
• W3125205308 cites W2149127304 @default.
• W3125205308 cites W2159360181 @default.
• W3125205308 cites W2160911117 @default.
• W3125205308 cites W2164017430 @default.
• W3125205308 cites W2170398231 @default.
• W3125205308 cites W2474578758 @default.
• W3125205308 cites W2519168730 @default.
• W3125205308 cites W2529401211 @default.
• W3125205308 cites W2613397238 @default.
• W3125205308 cites W2789880064 @default.
• W3125205308 cites W2888121871 @default.
• W3125205308 cites W2897196041 @default.
• W3125205308 cites W2906768986 @default.
• W3125205308 cites W2954980995 @default.
• W3125205308 cites W2970829499 @default.
• W3125205308 cites W2979051140 @default.
• W3125205308 cites W3001162266 @default.
• W3125205308 cites W3022541434 @default.
• W3125205308 cites W3027755488 @default.
• W3125205308 cites W3088648928 @default.
• W3125205308 cites W4235004829 @default.
• W3125205308 doi "https://doi.org/10.1136/gutjnl-2020-323719" @default.
• W3125205308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8286985" @default.
• W3125205308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33468536" @default.
• W3125205308 hasPublicationYear "2021" @default.
• W3125205308 type Work @default.
• W3125205308 sameAs 3125205308 @default.
• W3125205308 citedByCount "28" @default.
• W3125205308 countsByYear W31252053082021 @default.
• W3125205308 countsByYear W31252053082022 @default.
• W3125205308 countsByYear W31252053082023 @default.
• W3125205308 crossrefType "journal-article" @default.
• W3125205308 hasAuthorship W3125205308A5001254185 @default.
• W3125205308 hasAuthorship W3125205308A5003726335 @default.
• W3125205308 hasAuthorship W3125205308A5004785859 @default.
• W3125205308 hasAuthorship W3125205308A5005984287 @default.
• W3125205308 hasAuthorship W3125205308A5010057922 @default.
• W3125205308 hasAuthorship W3125205308A5012305407 @default.
• W3125205308 hasAuthorship W3125205308A5013764770 @default.
• W3125205308 hasAuthorship W3125205308A5036347175 @default.
• W3125205308 hasAuthorship W3125205308A5036764652 @default.
• W3125205308 hasAuthorship W3125205308A5043396915 @default.
• W3125205308 hasAuthorship W3125205308A5045134312 @default.
• W3125205308 hasAuthorship W3125205308A5049239234 @default.
• W3125205308 hasAuthorship W3125205308A5052443838 @default.
• W3125205308 hasAuthorship W3125205308A5055224390 @default.
• W3125205308 hasAuthorship W3125205308A5059698867 @default.
• W3125205308 hasAuthorship W3125205308A5067816171 @default.
• W3125205308 hasAuthorship W3125205308A5075877965 @default.
• W3125205308 hasAuthorship W3125205308A5076035375 @default.
• W3125205308 hasAuthorship W3125205308A5082271623 @default.

• next