FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125222955> ?p ?o ?g. }

• W3125222955 abstract "Blockade of PD-1, an indispensable physiological immunoregulatory mechanism, enhances immune activities and is widely used in the immunotherapy of cancer. This treatment often accompanies inflammatory complication called immune-related adverse events (irAE), most frequently in the skin. To analyze how skin inflammation develops by the blockade of PD-1-dependent immunoregulation, we studied the exacerbation of oxazolone-induced contact hypersensitivity by PD-L1 blockade. The inactivation of PD-1 signaling enhanced swelling of the skin with massive CD8 + T cell infiltration. Among PD-1-expressing cells, T cells were the predominant targets of anti-PD-L1 mAb treatment since PD-L1 blockade did not affect skin inflammation in RAG2 -/- mice. PD-L1 blockade during immunization with oxazolone significantly promoted the development of hapten-reactive T cells in the draining lymph nodes. The enhancement of local CD8 + T cell-dominant immune responses by PD-L1 blockade was correlated with the upregulation of CXCL9 and CXCL10. Challenges with a low dose of oxazolone did not demonstrate any significant dermatitis; however, the influence of PD-L1 blockade on T cell immunity was strong enough to cause the emergence of notable dermatitis in this suboptimal dosing, suggesting its relevance to dermal irAE development. In the low-dose setting, the blockade of CXCR3, receptor of CXCL9/10, prevented the induction of T cell-dominant inflammation by anti-PD-L1 mAb. This experimental approach reproduced CD8 + T cell-dominant form of cutaneous inflammation by the blockade of PD-L1 that has been observed in dermal irAE in human patients." @default.
• W3125222955 created "2021-02-01" @default.
• W3125222955 creator A5001442802 @default.
• W3125222955 creator A5004107843 @default.
• W3125222955 creator A5019039647 @default.
• W3125222955 creator A5038021836 @default.
• W3125222955 creator A5058510937 @default.
• W3125222955 creator A5073894405 @default.
• W3125222955 creator A5076187024 @default.
• W3125222955 date "2021-01-27" @default.
• W3125222955 modified "2023-09-26" @default.
• W3125222955 title "Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events" @default.
• W3125222955 cites W1678477267 @default.
• W3125222955 cites W1695995011 @default.
• W3125222955 cites W1950507937 @default.
• W3125222955 cites W1953840492 @default.
• W3125222955 cites W1972452655 @default.
• W3125222955 cites W1975445094 @default.
• W3125222955 cites W1991307757 @default.
• W3125222955 cites W2012805475 @default.
• W3125222955 cites W2018549708 @default.
• W3125222955 cites W2050184930 @default.
• W3125222955 cites W2051605675 @default.
• W3125222955 cites W2055522050 @default.
• W3125222955 cites W2056535502 @default.
• W3125222955 cites W2063264144 @default.
• W3125222955 cites W2063563584 @default.
• W3125222955 cites W2082355065 @default.
• W3125222955 cites W2082816999 @default.
• W3125222955 cites W2087447905 @default.
• W3125222955 cites W2104750134 @default.
• W3125222955 cites W2106943429 @default.
• W3125222955 cites W2120056104 @default.
• W3125222955 cites W2122940411 @default.
• W3125222955 cites W2129071472 @default.
• W3125222955 cites W2143478772 @default.
• W3125222955 cites W2153942285 @default.
• W3125222955 cites W2160834915 @default.
• W3125222955 cites W2161889530 @default.
• W3125222955 cites W2162970323 @default.
• W3125222955 cites W2178232953 @default.
• W3125222955 cites W2265285917 @default.
• W3125222955 cites W2301706587 @default.
• W3125222955 cites W2397739282 @default.
• W3125222955 cites W2404485673 @default.
• W3125222955 cites W2573158190 @default.
• W3125222955 cites W2606806644 @default.
• W3125222955 cites W2615301036 @default.
• W3125222955 cites W2751965733 @default.
• W3125222955 cites W2763062891 @default.
• W3125222955 cites W2807184339 @default.
• W3125222955 cites W2890056446 @default.
• W3125222955 cites W2894717949 @default.
• W3125222955 cites W2902268061 @default.
• W3125222955 cites W2909551877 @default.
• W3125222955 cites W2912725678 @default.
• W3125222955 cites W2945224722 @default.
• W3125222955 cites W2965378827 @default.
• W3125222955 cites W2969426509 @default.
• W3125222955 cites W2976280045 @default.
• W3125222955 cites W2977648831 @default.
• W3125222955 cites W2981460140 @default.
• W3125222955 cites W2996923341 @default.
• W3125222955 cites W2997277554 @default.
• W3125222955 cites W3023745224 @default.
• W3125222955 cites W3026699635 @default.
• W3125222955 cites W3092900611 @default.
• W3125222955 doi "https://doi.org/10.3389/fimmu.2020.618711" @default.
• W3125222955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7873368" @default.
• W3125222955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33584713" @default.
• W3125222955 hasPublicationYear "2021" @default.
• W3125222955 type Work @default.
• W3125222955 sameAs 3125222955 @default.
• W3125222955 citedByCount "2" @default.
• W3125222955 countsByYear W31252229552022 @default.
• W3125222955 crossrefType "journal-article" @default.
• W3125222955 hasAuthorship W3125222955A5001442802 @default.
• W3125222955 hasAuthorship W3125222955A5004107843 @default.
• W3125222955 hasAuthorship W3125222955A5019039647 @default.
• W3125222955 hasAuthorship W3125222955A5038021836 @default.
• W3125222955 hasAuthorship W3125222955A5058510937 @default.
• W3125222955 hasAuthorship W3125222955A5073894405 @default.
• W3125222955 hasAuthorship W3125222955A5076187024 @default.
• W3125222955 hasBestOaLocation W31252229551 @default.
• W3125222955 hasConcept C126322002 @default.
• W3125222955 hasConcept C154317977 @default.
• W3125222955 hasConcept C167672396 @default.
• W3125222955 hasConcept C170493617 @default.
• W3125222955 hasConcept C202751555 @default.
• W3125222955 hasConcept C203014093 @default.
• W3125222955 hasConcept C2776090121 @default.
• W3125222955 hasConcept C2776914184 @default.
• W3125222955 hasConcept C2778468042 @default.
• W3125222955 hasConcept C2779790080 @default.
• W3125222955 hasConcept C55493867 @default.
• W3125222955 hasConcept C71924100 @default.
• W3125222955 hasConcept C86803240 @default.
• W3125222955 hasConcept C8891405 @default.
• W3125222955 hasConceptScore W3125222955C126322002 @default.
• W3125222955 hasConceptScore W3125222955C154317977 @default.

• next