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- W3125268557 abstract "The adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used genome-wide association mapping coupled with genetic correlation analyses. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified negative genetic correlations among traits related to host colonization and survival in stressful environments. Such genetic constraints indicate that pleiotropic effects could limit the pathogen's ability to cause host damage. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations." @default.
- W3125268557 created "2021-02-01" @default.
- W3125268557 creator A5017444708 @default.
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- W3125268557 creator A5034723472 @default.
- W3125268557 creator A5037432627 @default.
- W3125268557 creator A5056400720 @default.
- W3125268557 date "2021-01-15" @default.
- W3125268557 modified "2023-10-17" @default.
- W3125268557 title "Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments" @default.
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