FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125277858> ?p ?o ?g. }

• W3125277858 endingPage "607" @default.
• W3125277858 startingPage "598" @default.
• W3125277858 abstract "The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism-related single nucleotide polymorphisms (SNPs), whose effect on NAFLD fibrosis is significantly modified by sex and menopausal status. We performed a cross-sectional, proof-of-concept study of 616 patients in the Duke NAFLD Clinical Database and Biorepository. The primary outcome was nonalcoholic steatohepatitis-Clinical Research Network (NASH-CRN) fibrosis stage. Menopause status was self-reported; age 51 years was used as a surrogate for menopause in patients with missing menopause data. The Metabochip was used to obtain 98,359 SNP genotypes in known metabolic pathway genes for each patient. We used additive genetic models to characterize sex and menopause-specific effects of SNP genotypes on NAFLD fibrosis stage. In the main effects analysis, none of the SNPs were associated with fibrosis at P < 0.05 after correcting for multiple comparisons. Twenty-five SNPs significantly interacted with sex/menopause to affect fibrosis stage (interaction P < 0.0001). After removal of loci in linkage disequilibrium, 10 independent loci were identified. Six were in the following genes: KCNIP4 (potassium voltage-gated channel interacting protein 4), PSORS1C1 (psoriasis susceptibility 1 candidate 1), KLHL8 (Kelch-like family member 8), GLRA1 (glycine receptor alpha 1), NOTCH2 (notch receptor 2), and PRKCH (protein kinase C eta), and four SNPs were intergenic. In stratified models, four SNPs were significant in premenopausal and postmenopausal women, three only in postmenopausal women, two in men and postmenopausal women, and one only in premenopausal women. Conclusion: We identified 10 loci with a significant sex/menopause interaction with respect to fibrosis. None of these SNPs were significant in all sex/menopause groups, suggesting modulation of genetic susceptibility to fibrosis by sex and menopause status. Future studies of genetic predictors of NAFLD progression should account for sex and menopause." @default.
• W3125277858 created "2021-02-01" @default.
• W3125277858 creator A5000423671 @default.
• W3125277858 creator A5011069724 @default.
• W3125277858 creator A5012085033 @default.
• W3125277858 creator A5020766248 @default.
• W3125277858 creator A5047141065 @default.
• W3125277858 creator A5049761062 @default.
• W3125277858 creator A5052915681 @default.
• W3125277858 creator A5061857570 @default.
• W3125277858 creator A5063412266 @default.
• W3125277858 creator A5075081857 @default.
• W3125277858 creator A5090688781 @default.
• W3125277858 date "2021-01-18" @default.
• W3125277858 modified "2023-10-17" @default.
• W3125277858 title "Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD" @default.
• W3125277858 cites W1799045559 @default.
• W3125277858 cites W1965512299 @default.
• W3125277858 cites W1966549856 @default.
• W3125277858 cites W1983634862 @default.
• W3125277858 cites W2002404972 @default.
• W3125277858 cites W2043372701 @default.
• W3125277858 cites W2054311777 @default.
• W3125277858 cites W2054608703 @default.
• W3125277858 cites W2056315356 @default.
• W3125277858 cites W2058252119 @default.
• W3125277858 cites W2058979870 @default.
• W3125277858 cites W2061182191 @default.
• W3125277858 cites W2083588619 @default.
• W3125277858 cites W2094504975 @default.
• W3125277858 cites W2101357408 @default.
• W3125277858 cites W2122884875 @default.
• W3125277858 cites W2137516998 @default.
• W3125277858 cites W2152115036 @default.
• W3125277858 cites W2161633633 @default.
• W3125277858 cites W2163065789 @default.
• W3125277858 cites W2204688218 @default.
• W3125277858 cites W2566842452 @default.
• W3125277858 cites W2615304062 @default.
• W3125277858 cites W2757709805 @default.
• W3125277858 cites W2772038101 @default.
• W3125277858 cites W2794722370 @default.
• W3125277858 cites W2797059772 @default.
• W3125277858 cites W2805977157 @default.
• W3125277858 cites W2913477601 @default.
• W3125277858 cites W2934946727 @default.
• W3125277858 cites W2960093361 @default.
• W3125277858 cites W3012389723 @default.
• W3125277858 cites W3015361084 @default.
• W3125277858 cites W3023490585 @default.
• W3125277858 cites W90736706 @default.
• W3125277858 doi "https://doi.org/10.1002/hep4.1668" @default.
• W3125277858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8034580" @default.
• W3125277858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33860118" @default.
• W3125277858 hasPublicationYear "2021" @default.
• W3125277858 type Work @default.
• W3125277858 sameAs 3125277858 @default.
• W3125277858 citedByCount "11" @default.
• W3125277858 countsByYear W31252778582022 @default.
• W3125277858 countsByYear W31252778582023 @default.
• W3125277858 crossrefType "journal-article" @default.
• W3125277858 hasAuthorship W3125277858A5000423671 @default.
• W3125277858 hasAuthorship W3125277858A5011069724 @default.
• W3125277858 hasAuthorship W3125277858A5012085033 @default.
• W3125277858 hasAuthorship W3125277858A5020766248 @default.
• W3125277858 hasAuthorship W3125277858A5047141065 @default.
• W3125277858 hasAuthorship W3125277858A5049761062 @default.
• W3125277858 hasAuthorship W3125277858A5052915681 @default.
• W3125277858 hasAuthorship W3125277858A5061857570 @default.
• W3125277858 hasAuthorship W3125277858A5063412266 @default.
• W3125277858 hasAuthorship W3125277858A5075081857 @default.
• W3125277858 hasAuthorship W3125277858A5090688781 @default.
• W3125277858 hasBestOaLocation W31252778581 @default.
• W3125277858 hasConcept C104317684 @default.
• W3125277858 hasConcept C126322002 @default.
• W3125277858 hasConcept C134018914 @default.
• W3125277858 hasConcept C135763542 @default.
• W3125277858 hasConcept C139275648 @default.
• W3125277858 hasConcept C143998085 @default.
• W3125277858 hasConcept C153209595 @default.
• W3125277858 hasConcept C2776954865 @default.
• W3125277858 hasConcept C2778562196 @default.
• W3125277858 hasConcept C2778772119 @default.
• W3125277858 hasConcept C2779134260 @default.
• W3125277858 hasConcept C2780559512 @default.
• W3125277858 hasConcept C35605836 @default.
• W3125277858 hasConcept C54355233 @default.
• W3125277858 hasConcept C60644358 @default.
• W3125277858 hasConcept C71924100 @default.
• W3125277858 hasConcept C86803240 @default.
• W3125277858 hasConceptScore W3125277858C104317684 @default.
• W3125277858 hasConceptScore W3125277858C126322002 @default.
• W3125277858 hasConceptScore W3125277858C134018914 @default.
• W3125277858 hasConceptScore W3125277858C135763542 @default.
• W3125277858 hasConceptScore W3125277858C139275648 @default.
• W3125277858 hasConceptScore W3125277858C143998085 @default.
• W3125277858 hasConceptScore W3125277858C153209595 @default.
• W3125277858 hasConceptScore W3125277858C2776954865 @default.

• next