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- W3125284506 abstract "Tauopathies define a broad range of neurodegenerative diseases that encompass pathological aggregation of the microtubule-associated protein tau. Although tau aggregation is a central feature of these diseases, their underlying pathobiology is remarkably heterogeneous at the molecular level. In this review, we summarize critical differences that account for this heterogeneity and contrast the physiological and pathological functions of tau. We focus on the recent understanding of its prion-like behavior that accounts for its spread in the brain. Moreover, we acknowledge the limited appreciation about how upstream cellular changes influence tauopathy. Dysfunction of the highly conserved endosomal trafficking complex retromer is found in numerous tauopathies such as Alzheimer's disease, Pick's disease, and progressive supranuclear palsy, and we discuss how this has emerged as a major contributor to various aspects of neurodegenerative diseases. In particular, we highlight recent investigations that have elucidated the contribution of retromer dysfunction to distinct measures of tauopathy such as tau hyperphosphorylation, aggregation, and impaired cognition and behavior. Finally, we discuss the potential benefit of targeting retromer for modifying disease burden and identify important considerations with such an approach moving toward clinical translation." @default.
- W3125284506 created "2021-02-01" @default.
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- W3125284506 creator A5027744719 @default.
- W3125284506 creator A5059629314 @default.
- W3125284506 date "2021-01-20" @default.
- W3125284506 modified "2023-10-17" @default.
- W3125284506 title "Retromer dysfunction at the nexus of tauopathies" @default.
- W3125284506 cites W1177858961 @default.
- W3125284506 cites W1458127710 @default.
- W3125284506 cites W1465395011 @default.
- W3125284506 cites W1509571186 @default.
- W3125284506 cites W150987474 @default.
- W3125284506 cites W1511517753 @default.
- W3125284506 cites W1512606137 @default.
- W3125284506 cites W1568323816 @default.
- W3125284506 cites W1593693427 @default.
- W3125284506 cites W1611407165 @default.
- W3125284506 cites W1864669235 @default.
- W3125284506 cites W1901737651 @default.
- W3125284506 cites W1929269608 @default.
- W3125284506 cites W1932699762 @default.
- W3125284506 cites W1940013884 @default.
- W3125284506 cites W1953962861 @default.
- W3125284506 cites W1964319599 @default.
- W3125284506 cites W1966312717 @default.
- W3125284506 cites W1968276382 @default.
- W3125284506 cites W1968937229 @default.
- W3125284506 cites W1971032265 @default.
- W3125284506 cites W1972553694 @default.
- W3125284506 cites W1973276273 @default.
- W3125284506 cites W1974760231 @default.
- W3125284506 cites W1977879318 @default.
- W3125284506 cites W1979363343 @default.
- W3125284506 cites W1981662243 @default.
- W3125284506 cites W1982307380 @default.
- W3125284506 cites W1983044117 @default.
- W3125284506 cites W1984191940 @default.
- W3125284506 cites W1984827962 @default.
- W3125284506 cites W1987339168 @default.
- W3125284506 cites W1988107440 @default.
- W3125284506 cites W1989970381 @default.
- W3125284506 cites W1993201929 @default.
- W3125284506 cites W1994282166 @default.
- W3125284506 cites W1995737263 @default.
- W3125284506 cites W1995779519 @default.
- W3125284506 cites W1996675875 @default.
- W3125284506 cites W2005755021 @default.
- W3125284506 cites W2006520473 @default.
- W3125284506 cites W2011520932 @default.
- W3125284506 cites W2018983416 @default.
- W3125284506 cites W2021734242 @default.
- W3125284506 cites W2021919788 @default.
- W3125284506 cites W2022120158 @default.
- W3125284506 cites W2025693096 @default.
- W3125284506 cites W2026771024 @default.
- W3125284506 cites W2027938923 @default.
- W3125284506 cites W2029486567 @default.
- W3125284506 cites W2030317956 @default.
- W3125284506 cites W2030674642 @default.
- W3125284506 cites W2032989196 @default.
- W3125284506 cites W2033713371 @default.
- W3125284506 cites W2036755018 @default.
- W3125284506 cites W2038120434 @default.
- W3125284506 cites W2039270622 @default.
- W3125284506 cites W2043111202 @default.
- W3125284506 cites W2043583138 @default.
- W3125284506 cites W2044430292 @default.
- W3125284506 cites W2049746112 @default.
- W3125284506 cites W2050252352 @default.
- W3125284506 cites W2052742260 @default.
- W3125284506 cites W2053082937 @default.
- W3125284506 cites W2053210112 @default.
- W3125284506 cites W2057042201 @default.
- W3125284506 cites W2057249855 @default.
- W3125284506 cites W2058054836 @default.
- W3125284506 cites W2058570072 @default.
- W3125284506 cites W2058880763 @default.
- W3125284506 cites W2059124041 @default.
- W3125284506 cites W2060046173 @default.
- W3125284506 cites W2063479157 @default.
- W3125284506 cites W2063690790 @default.
- W3125284506 cites W2067729657 @default.
- W3125284506 cites W2073914665 @default.
- W3125284506 cites W2074040932 @default.
- W3125284506 cites W2077422298 @default.
- W3125284506 cites W2081014274 @default.
- W3125284506 cites W2081966615 @default.
- W3125284506 cites W2082429191 @default.
- W3125284506 cites W2083829293 @default.
- W3125284506 cites W2084453905 @default.
- W3125284506 cites W2086477221 @default.
- W3125284506 cites W2088685810 @default.
- W3125284506 cites W2089215677 @default.
- W3125284506 cites W2089472076 @default.
- W3125284506 cites W2089607910 @default.
- W3125284506 cites W2090150925 @default.