Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125298061> ?p ?o ?g. }
- W3125298061 endingPage "1435" @default.
- W3125298061 startingPage "1423" @default.
- W3125298061 abstract "Many germ cells are eliminated during development, long before oogenesis or spermatogenesis. In mouse fetal testes, the majority of germ cell apoptosis coincides with the onset of male differentiation, suggesting coordination of these processes. We studied fetal germ-cell fates and discovered that both apoptosis and differentiation initiate in clonally related clusters. Lineage tracing confirmed that germ cells die as clones independent of intercellular bridges, suggesting that shared intrinsic properties are apoptotic determinants. We identified transcriptional heterogeneity among fetal germ cells that included an apoptosis-susceptible population characterized by failure to differentiate, whereas successful differentiation to prospermatogonia occurred through the expression of epigenetically regulated genes, including LINE1. Our results indicate that the fetal germ-cell fate is based on discrete cell-heritable identities. Elevated DNA methylation in the apoptosis-susceptible subpopulation supports our hypothesis that earlier errors in germ-cell epigenetic reprogramming derail differentiation in cellular progeny, leading to fetal apoptotic selection that ultimately improves the gamete quality." @default.
- W3125298061 created "2021-02-01" @default.
- W3125298061 creator A5004652722 @default.
- W3125298061 creator A5043899656 @default.
- W3125298061 creator A5061137912 @default.
- W3125298061 creator A5069100117 @default.
- W3125298061 creator A5080751444 @default.
- W3125298061 creator A5081870168 @default.
- W3125298061 date "2020-11-16" @default.
- W3125298061 modified "2023-10-15" @default.
- W3125298061 title "Apoptosis in the fetal testis eliminates developmentally defective germ cell clones" @default.
- W3125298061 cites W1767355390 @default.
- W3125298061 cites W1981531462 @default.
- W3125298061 cites W1985717790 @default.
- W3125298061 cites W1989027475 @default.
- W3125298061 cites W1990654003 @default.
- W3125298061 cites W1994831927 @default.
- W3125298061 cites W2006059948 @default.
- W3125298061 cites W2008516975 @default.
- W3125298061 cites W2008597649 @default.
- W3125298061 cites W2011081704 @default.
- W3125298061 cites W2019980431 @default.
- W3125298061 cites W2022127993 @default.
- W3125298061 cites W2022980477 @default.
- W3125298061 cites W2023844789 @default.
- W3125298061 cites W2030151514 @default.
- W3125298061 cites W2034661247 @default.
- W3125298061 cites W2051438014 @default.
- W3125298061 cites W2060153293 @default.
- W3125298061 cites W2060676189 @default.
- W3125298061 cites W2067102637 @default.
- W3125298061 cites W2070255306 @default.
- W3125298061 cites W2071040218 @default.
- W3125298061 cites W2071365780 @default.
- W3125298061 cites W2073966710 @default.
- W3125298061 cites W2074212982 @default.
- W3125298061 cites W2084214967 @default.
- W3125298061 cites W2084775418 @default.
- W3125298061 cites W2086778634 @default.
- W3125298061 cites W2092673707 @default.
- W3125298061 cites W2095639093 @default.
- W3125298061 cites W2096652998 @default.
- W3125298061 cites W2103616303 @default.
- W3125298061 cites W2115721083 @default.
- W3125298061 cites W2117144912 @default.
- W3125298061 cites W2121629312 @default.
- W3125298061 cites W2129895314 @default.
- W3125298061 cites W2130410032 @default.
- W3125298061 cites W2131793548 @default.
- W3125298061 cites W2151727566 @default.
- W3125298061 cites W2155183319 @default.
- W3125298061 cites W2157592237 @default.
- W3125298061 cites W2160710558 @default.
- W3125298061 cites W2161603964 @default.
- W3125298061 cites W2163067447 @default.
- W3125298061 cites W2168901267 @default.
- W3125298061 cites W2214074259 @default.
- W3125298061 cites W2402849265 @default.
- W3125298061 cites W2463736608 @default.
- W3125298061 cites W2520507621 @default.
- W3125298061 cites W2610617015 @default.
- W3125298061 cites W2613868166 @default.
- W3125298061 cites W2789804929 @default.
- W3125298061 cites W2790381244 @default.
- W3125298061 cites W2802719176 @default.
- W3125298061 cites W2946247230 @default.
- W3125298061 cites W2953152325 @default.
- W3125298061 doi "https://doi.org/10.1038/s41556-020-00603-8" @default.
- W3125298061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8389187" @default.
- W3125298061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33199844" @default.
- W3125298061 hasPublicationYear "2020" @default.
- W3125298061 type Work @default.
- W3125298061 sameAs 3125298061 @default.
- W3125298061 citedByCount "25" @default.
- W3125298061 countsByYear W31252980612020 @default.
- W3125298061 countsByYear W31252980612021 @default.
- W3125298061 countsByYear W31252980612022 @default.
- W3125298061 countsByYear W31252980612023 @default.
- W3125298061 crossrefType "journal-article" @default.
- W3125298061 hasAuthorship W3125298061A5004652722 @default.
- W3125298061 hasAuthorship W3125298061A5043899656 @default.
- W3125298061 hasAuthorship W3125298061A5061137912 @default.
- W3125298061 hasAuthorship W3125298061A5069100117 @default.
- W3125298061 hasAuthorship W3125298061A5080751444 @default.
- W3125298061 hasAuthorship W3125298061A5081870168 @default.
- W3125298061 hasBestOaLocation W31252980612 @default.
- W3125298061 hasConcept C104317684 @default.
- W3125298061 hasConcept C109825262 @default.
- W3125298061 hasConcept C144024400 @default.
- W3125298061 hasConcept C148738053 @default.
- W3125298061 hasConcept C1491633281 @default.
- W3125298061 hasConcept C149923435 @default.
- W3125298061 hasConcept C150194340 @default.
- W3125298061 hasConcept C190283241 @default.
- W3125298061 hasConcept C190446060 @default.
- W3125298061 hasConcept C190727270 @default.
- W3125298061 hasConcept C2779122487 @default.
- W3125298061 hasConcept C2908647359 @default.