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- W3125303609 abstract "Clades are monophyletic groups composed of a common ancestor and all its lineal descendants. As the propensity of virulence of a disease depends upon the type of clade the virus belongs to and it causes different fatality rates of disease in different countries, so the clade-wise analysis of SARS-CoV-2 isolates collected from different countries can illuminate the actual evolutionary relationships between them. In this study, 1566 SARS-CoV-2 genome sequences across ten Asian countries are collected, clustered, and characterized based on the clade they belong to. The isolates are compared to the Wuhan reference sequence” hCoV-19/Wuhan/WIV04/19″ to identify the mutations that occurred at different protein regions. Structural changes in amino acids due to mutations lead to functional instability of the proteins. Detailed clade-wise functional assessments are carried out to quantify the stability and vulnerability of the mutations occurring in SARS-CoV-2 genomes which can shade light on personalized prevention and treatment of the disease and encourage towards the invention of clade-specific vaccines." @default.
- W3125303609 created "2021-02-01" @default.
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- W3125303609 date "2021-04-01" @default.
- W3125303609 modified "2023-10-12" @default.
- W3125303609 title "Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs" @default.
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- W3125303609 doi "https://doi.org/10.1016/j.meegid.2021.104724" @default.
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