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- W3125308934 abstract "Abstract Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane. Different repair mechanisms and the bio-physical parameters required for efficient repair are now emerging from different research groups. However, less is known about when these mechanisms come into play. This review focuses on the existence of membrane disruptions and repair mechanisms in both physiological and pathological conditions, and across multiple cell types, albeit to different degrees. Fundamentally, irrespective of the source of membrane disruption, aberrant calcium influx is the common stimulus that activates the membrane repair response. Inadequate repair responses can tip the balance between physiology and pathology, highlighting the significance of plasma membrane integrity. For example, an over-activated repair response can promote cancer invasion, while the inability to efficiently repair membrane can drive neurodegeneration and muscular dystrophies. The interdisciplinary view explored here emphasises the widespread potential of targeting plasma membrane repair mechanisms for therapeutic purposes." @default.
- W3125308934 created "2021-02-01" @default.
- W3125308934 creator A5080420524 @default.
- W3125308934 creator A5080458261 @default.
- W3125308934 date "2021-01-19" @default.
- W3125308934 modified "2023-10-18" @default.
- W3125308934 title "Plasma membrane integrity in health and disease: significance and therapeutic potential" @default.
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