FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125322707> ?p ?o ?g. }

• W3125322707 abstract "Abstract This study presents a novel strategy that employs quantitative structure–activity relationship models for nanomaterials (Nano‐QSAR) for predicting transcriptomic pathway level response using lung tissue inflammation, an essential key event (KEs) in the existing adverse outcome pathway (AOP) for lung fibrosis, as a model response. Transcriptomic profiles of mouse lungs exposed to ten different multiwalled carbon nanotubes (MWCNTs) are analyzed using statistical and bioinformatics tools. Three pathways “agranulocyte adhesion and diapedesis,” “granulocyte adhesion and diapedesis,” and “acute phase signaling,” that (1) are commonly perturbed across the MWCNTs panel, (2) show dose response (Benchmark dose, BMDs), and (3) are anchored to the KEs identified in the lung fibrosis AOP, are considered in modelling. The three pathways are associated with tissue inflammation. The results show that the aspect ratio (κ) of MWCNTs is directly correlated with the pathway BMDs. The study establishes a methodology for QSAR construction based on canonical pathways and proposes a MWCNTs grouping strategy based on the κ‐values of the specific pathway associated genes. Finally, the study shows how the AOP framework can help guide QSAR modelling efforts; conversely, the outcome of the QSAR modelling can aid in refining certain aspects of the AOP in question (here, lung fibrosis)." @default.
• W3125322707 created "2021-02-01" @default.
• W3125322707 creator A5016513487 @default.
• W3125322707 creator A5027737864 @default.
• W3125322707 creator A5029689432 @default.
• W3125322707 creator A5048740200 @default.
• W3125322707 creator A5070480452 @default.
• W3125322707 creator A5082041803 @default.
• W3125322707 date "2021-01-27" @default.
• W3125322707 modified "2023-10-11" @default.
• W3125322707 title "Transcriptomics‐Based and AOP‐Informed Structure–Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes" @default.
• W3125322707 cites W1681224145 @default.
• W3125322707 cites W1905949689 @default.
• W3125322707 cites W1907554865 @default.
• W3125322707 cites W2000089305 @default.
• W3125322707 cites W2004788588 @default.
• W3125322707 cites W2036508923 @default.
• W3125322707 cites W2038304359 @default.
• W3125322707 cites W2038944150 @default.
• W3125322707 cites W2043548074 @default.
• W3125322707 cites W2067943075 @default.
• W3125322707 cites W2070782540 @default.
• W3125322707 cites W2095748236 @default.
• W3125322707 cites W2114330067 @default.
• W3125322707 cites W2120819444 @default.
• W3125322707 cites W2125111560 @default.
• W3125322707 cites W2142480093 @default.
• W3125322707 cites W2288337015 @default.
• W3125322707 cites W2297465774 @default.
• W3125322707 cites W2313757172 @default.
• W3125322707 cites W2398789413 @default.
• W3125322707 cites W2400138616 @default.
• W3125322707 cites W2463738079 @default.
• W3125322707 cites W2547353025 @default.
• W3125322707 cites W2548570236 @default.
• W3125322707 cites W2604444379 @default.
• W3125322707 cites W2754449970 @default.
• W3125322707 cites W2762451325 @default.
• W3125322707 cites W2791294307 @default.
• W3125322707 cites W2792909702 @default.
• W3125322707 cites W2801634291 @default.
• W3125322707 cites W2895848858 @default.
• W3125322707 cites W2943221775 @default.
• W3125322707 cites W2948244556 @default.
• W3125322707 cites W2990074081 @default.
• W3125322707 cites W3023042104 @default.
• W3125322707 cites W3032195143 @default.
• W3125322707 cites W4253536136 @default.
• W3125322707 cites W644895208 @default.
• W3125322707 doi "https://doi.org/10.1002/smll.202003465" @default.
• W3125322707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33502096" @default.
• W3125322707 hasPublicationYear "2021" @default.
• W3125322707 type Work @default.
• W3125322707 sameAs 3125322707 @default.
• W3125322707 citedByCount "27" @default.
• W3125322707 countsByYear W31253227072021 @default.
• W3125322707 countsByYear W31253227072022 @default.
• W3125322707 countsByYear W31253227072023 @default.
• W3125322707 crossrefType "journal-article" @default.
• W3125322707 hasAuthorship W3125322707A5016513487 @default.
• W3125322707 hasAuthorship W3125322707A5027737864 @default.
• W3125322707 hasAuthorship W3125322707A5029689432 @default.
• W3125322707 hasAuthorship W3125322707A5048740200 @default.
• W3125322707 hasAuthorship W3125322707A5070480452 @default.
• W3125322707 hasAuthorship W3125322707A5082041803 @default.
• W3125322707 hasBestOaLocation W31253227071 @default.
• W3125322707 hasConcept C104317684 @default.
• W3125322707 hasConcept C142724271 @default.
• W3125322707 hasConcept C150194340 @default.
• W3125322707 hasConcept C162317418 @default.
• W3125322707 hasConcept C164126121 @default.
• W3125322707 hasConcept C185592680 @default.
• W3125322707 hasConcept C192562407 @default.
• W3125322707 hasConcept C203014093 @default.
• W3125322707 hasConcept C2776914184 @default.
• W3125322707 hasConcept C2779230013 @default.
• W3125322707 hasConcept C2780559512 @default.
• W3125322707 hasConcept C2910206359 @default.
• W3125322707 hasConcept C55493867 @default.
• W3125322707 hasConcept C60644358 @default.
• W3125322707 hasConcept C70721500 @default.
• W3125322707 hasConcept C71924100 @default.
• W3125322707 hasConcept C86803240 @default.
• W3125322707 hasConcept C93231420 @default.
• W3125322707 hasConceptScore W3125322707C104317684 @default.
• W3125322707 hasConceptScore W3125322707C142724271 @default.
• W3125322707 hasConceptScore W3125322707C150194340 @default.
• W3125322707 hasConceptScore W3125322707C162317418 @default.
• W3125322707 hasConceptScore W3125322707C164126121 @default.
• W3125322707 hasConceptScore W3125322707C185592680 @default.
• W3125322707 hasConceptScore W3125322707C192562407 @default.
• W3125322707 hasConceptScore W3125322707C203014093 @default.
• W3125322707 hasConceptScore W3125322707C2776914184 @default.
• W3125322707 hasConceptScore W3125322707C2779230013 @default.
• W3125322707 hasConceptScore W3125322707C2780559512 @default.
• W3125322707 hasConceptScore W3125322707C2910206359 @default.
• W3125322707 hasConceptScore W3125322707C55493867 @default.
• W3125322707 hasConceptScore W3125322707C60644358 @default.
• W3125322707 hasConceptScore W3125322707C70721500 @default.
• W3125322707 hasConceptScore W3125322707C71924100 @default.

• next