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- W3125325632 abstract "Adenoid cystic carcinoma of the lower respiratory tract is a rare indolent neoplasm with prolonged survival, propensity for recurrences and metastasis years after initial therapy(1). We report the presentation, treatment and outcome an uncommon tumor adenoid cystic carcinoma of trachea.METHOD We collected retrospective data about our patient, treated in 2007 from our Hospital Information system. RESULTS 40 year old gentleman presented with the complaints of cough and progressive dyspnea of 9 months duration and hoarseness for 1 month duration. Bronchoscopy showed shiny soft polypoid lesion almost completely obstructing the tracheal lumen. MRI of the neck showed there was a mid-tracheal growth from 4 cm to 5.7 cm of carina partially obstructing the lumen with peri-tracheal fat planes involvement and few peritracheal nodes. He underwent tracheal resection with primary anastomosis. Histopathology specimen was reported as Intermediate to high grade adenoid cystic carcinoma with perineural invasion, infiltrating entire thickness with extension into soft tissue involving the margins. He subsequently received postoperative adjuvant radiation therapy using Cobalt 60 beam and a dose of 40 Gy in 20 fractions to midplane by AP-PA technique during phase 1 and 20 Gy in 10 fractions to tumor volume with oblique pair beams during phase 2. He tolerated the treatment well. He was disease free till August 2015 (8 years of follow up). CONCLUSION ACC of the trachea is a rare presentation of an indolent neoplasm .Successful tumor control with optimal conventional techniques still holds promise in the current era of conformal techniques.The challenge is to find the best therapeutic regimen aiming for a true cure and also to discover the best systemic therapy by expounding on molecular studies leading to targeted cell therapy to address a currently notable chemoresistant cancer. A multicenter long-term study including ACC of the head and neck region will be desirable." @default.
- W3125325632 created "2021-02-01" @default.
- W3125325632 creator A5081046177 @default.
- W3125325632 date "2019-12-30" @default.
- W3125325632 modified "2023-09-23" @default.
- W3125325632 title "ADENOID CYSTIC CARCINOMA TRACHEA UNUSUAL CASE" @default.
- W3125325632 hasPublicationYear "2019" @default.
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