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• W3125343191 abstract "Disruptions of brain-gut axis have been implicated in the progression of a variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and injuries, including traumatic brain injury (TBI). TBI is a chronic disease process characterized by persistent secondary injury processes which can be exacerbated by subsequent challenges. Enteric pathogen infection during chronic TBI worsened cortical lesion volume; however, the pathophysiological mechanisms underlying the damaging effects of enteric challenge during chronic TBI remain unknown. This preclinical study examined the effect of intestinal inflammation during chronic TBI on associated neurobehavioral and neuropathological outcomes, systemic inflammation, and dysautonomia.Dextran sodium sulfate (DSS) was administered to adult male C57BL/6NCrl mice 28 days following craniotomy (Sham) or TBI for 7 days to induce intestinal inflammation, followed by a return to normal drinking water for an additional 7 to 28 days for recovery; uninjured animals (Naïve) served as an additional control group. Behavioral testing was carried out prior to, during, and following DSS administration to assess changes in motor and cognitive function, social behavior, and mood. Electrocardiography was performed to examine autonomic balance. Brains were collected for histological and molecular analyses of injury lesion, neurodegeneration, and neuroinflammation. Blood, colons, spleens, mesenteric lymph nodes (mLNs), and thymus were collected for morphometric analyses and/or immune characterization by flow cytometry.Intestinal inflammation 28 days after craniotomy or TBI persistently induced, or exacerbated, respectively, deficits in fine motor coordination, cognition, social behavior, and anxiety-like behavior. Behavioral changes were associated with an induction, or exacerbation, of hippocampal neuronal cell loss and microglial activation in Sham and TBI mice administered DSS, respectively. Acute DSS administration resulted in a sustained systemic immune response with increases in myeloid cells in blood and spleen, as well as myeloid cells and lymphocytes in mesenteric lymph nodes. Dysautonomia was also induced in Sham and TBI mice administered DSS, with increased sympathetic tone beginning during DSS administration and persisting through the first recovery week.Intestinal inflammation during chronic experimental TBI causes a sustained systemic immune response and altered autonomic balance that are associated with microglial activation, increased neurodegeneration, and persistent neurological deficits." @default.
• W3125343191 created "2021-02-01" @default.
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• W3125343191 date "2021-01-18" @default.
• W3125343191 modified "2023-10-17" @default.
• W3125343191 title "Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits" @default.
• W3125343191 cites W1482462123 @default.
• W3125343191 cites W1512073517 @default.
• W3125343191 cites W1571044946 @default.
• W3125343191 cites W1577384402 @default.
• W3125343191 cites W1596258860 @default.
• W3125343191 cites W1833774496 @default.
• W3125343191 cites W1865242748 @default.
• W3125343191 cites W1913365550 @default.
• W3125343191 cites W1967084138 @default.
• W3125343191 cites W1970629813 @default.
• W3125343191 cites W1974831104 @default.
• W3125343191 cites W1974995288 @default.
• W3125343191 cites W1981910546 @default.
• W3125343191 cites W1983449280 @default.
• W3125343191 cites W1983615367 @default.
• W3125343191 cites W1986367298 @default.
• W3125343191 cites W1988706813 @default.
• W3125343191 cites W1993834781 @default.
• W3125343191 cites W1994282093 @default.
• W3125343191 cites W1994580609 @default.
• W3125343191 cites W1998598469 @default.
• W3125343191 cites W2003110685 @default.
• W3125343191 cites W2003440769 @default.
• W3125343191 cites W2013415299 @default.
• W3125343191 cites W2016152913 @default.
• W3125343191 cites W2018706685 @default.
• W3125343191 cites W2022119717 @default.
• W3125343191 cites W2034109955 @default.
• W3125343191 cites W2035408187 @default.
• W3125343191 cites W2047211632 @default.
• W3125343191 cites W2047253772 @default.
• W3125343191 cites W2050552145 @default.
• W3125343191 cites W2052160605 @default.
• W3125343191 cites W2056013076 @default.
• W3125343191 cites W2058035812 @default.
• W3125343191 cites W2061931936 @default.
• W3125343191 cites W2067451082 @default.
• W3125343191 cites W2068121565 @default.
• W3125343191 cites W2069225082 @default.
• W3125343191 cites W2071772175 @default.
• W3125343191 cites W2076847906 @default.
• W3125343191 cites W2081084897 @default.
• W3125343191 cites W2085702304 @default.
• W3125343191 cites W2086010796 @default.
• W3125343191 cites W2087412997 @default.
• W3125343191 cites W2088342461 @default.
• W3125343191 cites W2091975706 @default.
• W3125343191 cites W2092044187 @default.
• W3125343191 cites W2096019298 @default.
• W3125343191 cites W2097861438 @default.
• W3125343191 cites W2117673387 @default.
• W3125343191 cites W2125284469 @default.
• W3125343191 cites W2129939868 @default.
• W3125343191 cites W2137619324 @default.
• W3125343191 cites W2138629438 @default.
• W3125343191 cites W2141046689 @default.
• W3125343191 cites W2144531560 @default.
• W3125343191 cites W2146828356 @default.
• W3125343191 cites W2149958822 @default.
• W3125343191 cites W2154170498 @default.
• W3125343191 cites W2158658606 @default.
• W3125343191 cites W2158928937 @default.
• W3125343191 cites W2171688713 @default.
• W3125343191 cites W2209119157 @default.
• W3125343191 cites W2237921172 @default.
• W3125343191 cites W2285064633 @default.
• W3125343191 cites W2290890702 @default.
• W3125343191 cites W2332044667 @default.
• W3125343191 cites W2335851787 @default.
• W3125343191 cites W2335873363 @default.
• W3125343191 cites W2345500865 @default.
• W3125343191 cites W2345917271 @default.
• W3125343191 cites W2414288692 @default.
• W3125343191 cites W2517695096 @default.
• W3125343191 cites W2518987888 @default.
• W3125343191 cites W2585189863 @default.
• W3125343191 cites W2588997555 @default.
• W3125343191 cites W2594452358 @default.
• W3125343191 cites W2595497435 @default.
• W3125343191 cites W2598458188 @default.
• W3125343191 cites W2600321955 @default.
• W3125343191 cites W2606006288 @default.
• W3125343191 cites W2614123838 @default.
• W3125343191 cites W2616944621 @default.
• W3125343191 cites W2730074009 @default.

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