FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125372914> ?p ?o ?g. }

• W3125372914 endingPage "162" @default.
• W3125372914 startingPage "152" @default.
• W3125372914 abstract "Inflammatory processes play an important role in the pathophysiology of major depressive disorder (MDD), but their relevance for specific symptoms such as neurocognitive impairment is rarely investigated.In this observational study, we investigated the changes of leukocyte chemokine (C-C motif) receptor 5 (CCR5) and ligand 5 (CCL5) mRNA levels and inflammatory cytokines in 60 MDD patients before (PRE) and after 5 weeks (W5) of antidepressive treatment in relation to therapy response and alterations in cognitive functions by means of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We hypothesized that elevated CCR5 and CCL5 levels in depressed patients would decrease upon treatment and could differ with regard to cognitive impairment associated with MDD.Both CCR5 and CCL5 levels were significantly decreased in the responder group compared to nonresponders even before treatment. The cytokine IL-6 as a marker of inflammation in depression did not show a difference before treatment in future responders versus nonresponders, but decreased significantly upon antidepressive therapy. Regarding neurocognitive impairment in MDD patients, an increased misperception of the emotion anger after 5 weeks of treatment proved to be associated with a more pronounced change in CCR5, and the perception of the emotion disgust became faster along with a stronger decrease in CCL5 over the same time. Executive functions typically impaired in MDD patients were not markedly associated with alterations in CCR5/CCL5.CCR5 and CCL5 are important in the targeting of immune cells by HIV. This is the first study providing valuable hints that both CCR5 and CCL5 might also serve as markers of therapy response prediction in MDD. Regarding neurocognitive impairment in depression, CCR5 and CCL5 did not reveal characteristic changes upon MDD treatment such as executive functions, which are probably delayed. However, changes of emotional perception appear to be an earlier responding feature." @default.
• W3125372914 created "2021-02-01" @default.
• W3125372914 creator A5000469824 @default.
• W3125372914 creator A5008825383 @default.
• W3125372914 creator A5036384343 @default.
• W3125372914 creator A5048419237 @default.
• W3125372914 creator A5050065025 @default.
• W3125372914 creator A5050266772 @default.
• W3125372914 creator A5052606056 @default.
• W3125372914 creator A5061720289 @default.
• W3125372914 creator A5071160306 @default.
• W3125372914 creator A5075548935 @default.
• W3125372914 creator A5079611323 @default.
• W3125372914 date "2020-01-01" @default.
• W3125372914 modified "2023-10-16" @default.
• W3125372914 title "Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment" @default.
• W3125372914 cites W1606369535 @default.
• W3125372914 cites W1692828690 @default.
• W3125372914 cites W1951724000 @default.
• W3125372914 cites W1985438873 @default.
• W3125372914 cites W1987785379 @default.
• W3125372914 cites W1989701896 @default.
• W3125372914 cites W1996454121 @default.
• W3125372914 cites W1997192150 @default.
• W3125372914 cites W2003982930 @default.
• W3125372914 cites W2011696424 @default.
• W3125372914 cites W2019459590 @default.
• W3125372914 cites W2024411037 @default.
• W3125372914 cites W2034038466 @default.
• W3125372914 cites W2040016252 @default.
• W3125372914 cites W2059431497 @default.
• W3125372914 cites W2064953858 @default.
• W3125372914 cites W2069809946 @default.
• W3125372914 cites W2075926473 @default.
• W3125372914 cites W2081558146 @default.
• W3125372914 cites W2098082628 @default.
• W3125372914 cites W2111825772 @default.
• W3125372914 cites W2112350722 @default.
• W3125372914 cites W2114613490 @default.
• W3125372914 cites W2129579709 @default.
• W3125372914 cites W2134586420 @default.
• W3125372914 cites W2134948477 @default.
• W3125372914 cites W2165273254 @default.
• W3125372914 cites W2202941903 @default.
• W3125372914 cites W2280064070 @default.
• W3125372914 cites W2310081349 @default.
• W3125372914 cites W2416732024 @default.
• W3125372914 cites W2561607968 @default.
• W3125372914 cites W2582903515 @default.
• W3125372914 cites W2608743161 @default.
• W3125372914 cites W2624751168 @default.
• W3125372914 cites W2755049020 @default.
• W3125372914 cites W2760604407 @default.
• W3125372914 cites W2809450761 @default.
• W3125372914 cites W2917730612 @default.
• W3125372914 cites W2919938711 @default.
• W3125372914 cites W2922405748 @default.
• W3125372914 cites W2945318633 @default.
• W3125372914 cites W2968391207 @default.
• W3125372914 cites W2969919519 @default.
• W3125372914 cites W2973677178 @default.
• W3125372914 cites W3008933628 @default.
• W3125372914 cites W3018326882 @default.
• W3125372914 cites W336706996 @default.
• W3125372914 cites W581977681 @default.
• W3125372914 cites W766038751 @default.
• W3125372914 cites W92043842 @default.
• W3125372914 cites W2464034395 @default.
• W3125372914 doi "https://doi.org/10.1159/000513093" @default.
• W3125372914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8006585" @default.
• W3125372914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33503626" @default.
• W3125372914 hasPublicationYear "2020" @default.
• W3125372914 type Work @default.
• W3125372914 sameAs 3125372914 @default.
• W3125372914 citedByCount "9" @default.
• W3125372914 countsByYear W31253729142021 @default.
• W3125372914 countsByYear W31253729142022 @default.
• W3125372914 countsByYear W31253729142023 @default.
• W3125372914 crossrefType "journal-article" @default.
• W3125372914 hasAuthorship W3125372914A5000469824 @default.
• W3125372914 hasAuthorship W3125372914A5008825383 @default.
• W3125372914 hasAuthorship W3125372914A5036384343 @default.
• W3125372914 hasAuthorship W3125372914A5048419237 @default.
• W3125372914 hasAuthorship W3125372914A5050065025 @default.
• W3125372914 hasAuthorship W3125372914A5050266772 @default.
• W3125372914 hasAuthorship W3125372914A5052606056 @default.
• W3125372914 hasAuthorship W3125372914A5061720289 @default.
• W3125372914 hasAuthorship W3125372914A5071160306 @default.
• W3125372914 hasAuthorship W3125372914A5075548935 @default.
• W3125372914 hasAuthorship W3125372914A5079611323 @default.
• W3125372914 hasBestOaLocation W31253729141 @default.
• W3125372914 hasConcept C116484652 @default.
• W3125372914 hasConcept C118552586 @default.
• W3125372914 hasConcept C126322002 @default.
• W3125372914 hasConcept C13373296 @default.
• W3125372914 hasConcept C139719470 @default.
• W3125372914 hasConcept C143998085 @default.
• W3125372914 hasConcept C15744967 @default.

• next