Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125479316> ?p ?o ?g. }
- W3125479316 abstract "Abstract The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus within the Orthocoronavirinae causing an emergent infectious disease in humans, the ongoing coronavirus disease 2019 pandemic (COVID-19). Due to the high zoonotic potential of these viruses, it is critical to unravel their evolutionary history of host species shift, adaptation and emergence. Only such knowledge can guide virus discovery, surveillance and research efforts to identify viruses posing a pandemic risk in humans. We present a comprehensive analysis of the composition and codon usage bias of the 82 Orthocoronavirinae members, infecting 47 different avian and mammalian hosts. Our results clearly establish that synonymous codon usage varies widely among viruses and is only weakly dependent on the type of host they infect. Instead, we identify mutational bias towards AT-enrichment and selection against CpG dinucleotides as the main factors responsible of the codon usage bias variation. Further insight on the mutational equilibrium within Orthocoronavirinae revealed that most coronavirus genomes are close to their neutral equilibrium, the exception is the three recently-infecting human coronaviruses, which lie further away from the mutational equilibrium than their endemic human coronavirus counterparts. Finally, our results suggest that while replicating in humans SARS-CoV-2 is slowly becoming AT-richer, likely until attaining a new mutational equilibrium." @default.
- W3125479316 created "2021-02-01" @default.
- W3125479316 creator A5006544717 @default.
- W3125479316 creator A5074079969 @default.
- W3125479316 date "2021-01-26" @default.
- W3125479316 modified "2023-10-14" @default.
- W3125479316 title "Variability in codon usage in Coronaviruses is mainly driven by mutational bias and selective constraints on CpG dinucleotide" @default.
- W3125479316 cites W1573009562 @default.
- W3125479316 cites W1963781218 @default.
- W3125479316 cites W1976608804 @default.
- W3125479316 cites W1989298969 @default.
- W3125479316 cites W1998092469 @default.
- W3125479316 cites W2000364429 @default.
- W3125479316 cites W2008811126 @default.
- W3125479316 cites W2011343696 @default.
- W3125479316 cites W2011828065 @default.
- W3125479316 cites W2013321787 @default.
- W3125479316 cites W2024800238 @default.
- W3125479316 cites W2029132648 @default.
- W3125479316 cites W2032783993 @default.
- W3125479316 cites W2034525444 @default.
- W3125479316 cites W2035438291 @default.
- W3125479316 cites W2035475950 @default.
- W3125479316 cites W2039790548 @default.
- W3125479316 cites W2051242197 @default.
- W3125479316 cites W2057088297 @default.
- W3125479316 cites W2058689581 @default.
- W3125479316 cites W2066829062 @default.
- W3125479316 cites W2073010081 @default.
- W3125479316 cites W2076793571 @default.
- W3125479316 cites W2077523678 @default.
- W3125479316 cites W2084241014 @default.
- W3125479316 cites W2095685450 @default.
- W3125479316 cites W2096406964 @default.
- W3125479316 cites W2099731870 @default.
- W3125479316 cites W2100238259 @default.
- W3125479316 cites W2101551832 @default.
- W3125479316 cites W2104474203 @default.
- W3125479316 cites W2109878231 @default.
- W3125479316 cites W2115622704 @default.
- W3125479316 cites W2121043033 @default.
- W3125479316 cites W2134463805 @default.
- W3125479316 cites W2140488419 @default.
- W3125479316 cites W2141052558 @default.
- W3125479316 cites W2141344219 @default.
- W3125479316 cites W2142391696 @default.
- W3125479316 cites W2147126179 @default.
- W3125479316 cites W2147363251 @default.
- W3125479316 cites W2148734328 @default.
- W3125479316 cites W2148972293 @default.
- W3125479316 cites W2156536014 @default.
- W3125479316 cites W2159365979 @default.
- W3125479316 cites W2163194377 @default.
- W3125479316 cites W2164393923 @default.
- W3125479316 cites W2164618276 @default.
- W3125479316 cites W2165479490 @default.
- W3125479316 cites W2186868783 @default.
- W3125479316 cites W2275381817 @default.
- W3125479316 cites W2281124081 @default.
- W3125479316 cites W2282841281 @default.
- W3125479316 cites W2283228097 @default.
- W3125479316 cites W2524169008 @default.
- W3125479316 cites W2558756978 @default.
- W3125479316 cites W2588835098 @default.
- W3125479316 cites W2624323480 @default.
- W3125479316 cites W2624387535 @default.
- W3125479316 cites W2700382303 @default.
- W3125479316 cites W2722272303 @default.
- W3125479316 cites W2757826226 @default.
- W3125479316 cites W2759289851 @default.
- W3125479316 cites W2794858691 @default.
- W3125479316 cites W2806155816 @default.
- W3125479316 cites W2903899730 @default.
- W3125479316 cites W2950345860 @default.
- W3125479316 cites W2951559571 @default.
- W3125479316 cites W2953071745 @default.
- W3125479316 cites W2954334349 @default.
- W3125479316 cites W2972032753 @default.
- W3125479316 cites W2993223524 @default.
- W3125479316 cites W2996177842 @default.
- W3125479316 cites W3000771439 @default.
- W3125479316 cites W3001897055 @default.
- W3125479316 cites W3012215772 @default.
- W3125479316 cites W3013452103 @default.
- W3125479316 cites W3014449331 @default.
- W3125479316 cites W3015622879 @default.
- W3125479316 cites W3021164156 @default.
- W3125479316 cites W3023883119 @default.
- W3125479316 cites W3025482887 @default.
- W3125479316 cites W3025620739 @default.
- W3125479316 cites W3029771624 @default.
- W3125479316 cites W3035280753 @default.
- W3125479316 cites W3035786310 @default.
- W3125479316 cites W3043112513 @default.
- W3125479316 cites W3046566329 @default.
- W3125479316 cites W3085533176 @default.
- W3125479316 doi "https://doi.org/10.1101/2021.01.26.428296" @default.
- W3125479316 hasPublicationYear "2021" @default.
- W3125479316 type Work @default.
- W3125479316 sameAs 3125479316 @default.