Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125482080> ?p ?o ?g. }
- W3125482080 abstract "Toll-like receptor 2 (TLR2) is implicated in various pathologies, mainly in terms of its function within innate immune cells. However, TLR2 is also present in endothelial cells. Here, we explored the physiological and pathophysiological roles of endothelial TLR2 signaling. We found that TLR2 was highly abundant in the endothelium within various tissues using TLR2-IRES-EGFP reporter mice and was required for proinflammatory endothelial cell function. Endothelial cells lacking TLR2 exhibited reduced proinflammatory potential at the protein, cell, and tissue levels. Loss of endothelial TLR2 blunted the inflammatory response to both exogenous and endogenous danger signals in endothelial cells in culture and in vivo. Endothelial TLR2 promoted tumor growth, angiogenesis, and protumorigenic immune cell recruitment in a mouse model of prostate cancer. Furthermore, the cell surface localization of P-selectin and the subsequent production of other critical cell adhesion molecules (such as E-selectin, ICAM-1 and VCAM-1) that recruit immune cells required endothelial TLR2. Our findings demonstrate that endothelial cells actively contribute to innate immune pathways and propose that endothelial TLR2 has a pathological role in proinflammatory conditions." @default.
- W3125482080 created "2021-02-01" @default.
- W3125482080 creator A5006472419 @default.
- W3125482080 creator A5009011367 @default.
- W3125482080 creator A5021055627 @default.
- W3125482080 creator A5021348310 @default.
- W3125482080 creator A5032316244 @default.
- W3125482080 creator A5043277346 @default.
- W3125482080 creator A5053281496 @default.
- W3125482080 creator A5090246252 @default.
- W3125482080 date "2021-01-19" @default.
- W3125482080 modified "2023-10-02" @default.
- W3125482080 title "Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis" @default.
- W3125482080 cites W1612531854 @default.
- W3125482080 cites W1962125373 @default.
- W3125482080 cites W1969103696 @default.
- W3125482080 cites W1972230443 @default.
- W3125482080 cites W1975915404 @default.
- W3125482080 cites W1978369960 @default.
- W3125482080 cites W2004288786 @default.
- W3125482080 cites W2009592273 @default.
- W3125482080 cites W2013586539 @default.
- W3125482080 cites W2021736304 @default.
- W3125482080 cites W2022512688 @default.
- W3125482080 cites W2033023829 @default.
- W3125482080 cites W2042197511 @default.
- W3125482080 cites W2050728089 @default.
- W3125482080 cites W2051637267 @default.
- W3125482080 cites W2059217150 @default.
- W3125482080 cites W2065878448 @default.
- W3125482080 cites W2069544210 @default.
- W3125482080 cites W2072232931 @default.
- W3125482080 cites W2072787615 @default.
- W3125482080 cites W2073741182 @default.
- W3125482080 cites W2082510462 @default.
- W3125482080 cites W2086131760 @default.
- W3125482080 cites W2087224318 @default.
- W3125482080 cites W2087668378 @default.
- W3125482080 cites W2092032357 @default.
- W3125482080 cites W2104285446 @default.
- W3125482080 cites W2105286884 @default.
- W3125482080 cites W2106102605 @default.
- W3125482080 cites W2124109795 @default.
- W3125482080 cites W2125747195 @default.
- W3125482080 cites W2138207763 @default.
- W3125482080 cites W2144032514 @default.
- W3125482080 cites W2149611550 @default.
- W3125482080 cites W2152415811 @default.
- W3125482080 cites W2153539209 @default.
- W3125482080 cites W2157339124 @default.
- W3125482080 cites W2157752762 @default.
- W3125482080 cites W2161091841 @default.
- W3125482080 cites W2168852012 @default.
- W3125482080 cites W2170164215 @default.
- W3125482080 cites W2170551349 @default.
- W3125482080 cites W2203467993 @default.
- W3125482080 cites W224680839 @default.
- W3125482080 cites W2257383956 @default.
- W3125482080 cites W2735527928 @default.
- W3125482080 cites W2746841787 @default.
- W3125482080 cites W2773157047 @default.
- W3125482080 cites W2799310615 @default.
- W3125482080 cites W2888828176 @default.
- W3125482080 cites W2889222907 @default.
- W3125482080 cites W2948132055 @default.
- W3125482080 cites W3006650868 @default.
- W3125482080 cites W3027918021 @default.
- W3125482080 cites W39392417 @default.
- W3125482080 doi "https://doi.org/10.1126/scisignal.abc5371" @default.
- W3125482080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8112454" @default.
- W3125482080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33986920" @default.
- W3125482080 hasPublicationYear "2021" @default.
- W3125482080 type Work @default.
- W3125482080 sameAs 3125482080 @default.
- W3125482080 citedByCount "22" @default.
- W3125482080 countsByYear W31254820802021 @default.
- W3125482080 countsByYear W31254820802022 @default.
- W3125482080 countsByYear W31254820802023 @default.
- W3125482080 crossrefType "journal-article" @default.
- W3125482080 hasAuthorship W3125482080A5006472419 @default.
- W3125482080 hasAuthorship W3125482080A5009011367 @default.
- W3125482080 hasAuthorship W3125482080A5021055627 @default.
- W3125482080 hasAuthorship W3125482080A5021348310 @default.
- W3125482080 hasAuthorship W3125482080A5032316244 @default.
- W3125482080 hasAuthorship W3125482080A5043277346 @default.
- W3125482080 hasAuthorship W3125482080A5053281496 @default.
- W3125482080 hasAuthorship W3125482080A5090246252 @default.
- W3125482080 hasBestOaLocation W31254820802 @default.
- W3125482080 hasConcept C123012128 @default.
- W3125482080 hasConcept C134018914 @default.
- W3125482080 hasConcept C136449434 @default.
- W3125482080 hasConcept C16224149 @default.
- W3125482080 hasConcept C164027704 @default.
- W3125482080 hasConcept C202751555 @default.
- W3125482080 hasConcept C203014093 @default.
- W3125482080 hasConcept C2776914184 @default.
- W3125482080 hasConcept C2776992346 @default.
- W3125482080 hasConcept C2780394083 @default.
- W3125482080 hasConcept C2781236682 @default.
- W3125482080 hasConcept C502942594 @default.