FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125504744> ?p ?o ?g. }

• W3125504744 endingPage "961" @default.
• W3125504744 startingPage "961" @default.
• W3125504744 abstract "We have shown that autoxidized polyphenolic nutraceuticals oxidize H2S to polysulfides and thiosulfate and this may convey their cytoprotective effects. Polyphenol reactivity is largely attributed to the B ring, which is usually a form of hydroxyquinone (HQ). Here, we examine the effects of HQs on sulfur metabolism using H2S- and polysulfide-specific fluorophores (AzMC and SSP4, respectively) and thiosulfate sensitive silver nanoparticles (AgNP). In buffer, 1,4-dihydroxybenzene (1,4-DB), 1,4-benzoquinone (1,4-BQ), pyrogallol (PG) and gallic acid (GA) oxidized H2S to polysulfides and thiosulfate, whereas 1,2-DB, 1,3-DB, 1,2-dihydroxy,3,4-benzoquinone and shikimic acid did not. In addition, 1,4-DB, 1,4-BQ, PG and GA also increased polysulfide production in HEK293 cells. In buffer, H2S oxidation by 1,4-DB was oxygen-dependent, partially inhibited by tempol and trolox, and absorbance spectra were consistent with redox cycling between HQ autoxidation and H2S-mediated reduction. Neither 1,2-DB, 1,3-DB, 1,4-DB nor 1,4-BQ reduced polysulfides to H2S in either 21% or 0% oxygen. Epinephrine and norepinephrine also oxidized H2S to polysulfides and thiosulfate; dopamine and tyrosine were ineffective. Polyphenones were also examined, but only 2,5-dihydroxy- and 2,3,4-trihydroxybenzophenones oxidized H2S. These results show that H2S is readily oxidized by specific hydroxyquinones and quinones, most likely through the formation of a semiquinone radical intermediate derived from either reaction of oxygen with the reduced quinones, or from direct reaction between H2S and quinones. We propose that polysulfide production by these reactions contributes to the health-promoting benefits of polyphenolic nutraceuticals." @default.
• W3125504744 created "2021-02-01" @default.
• W3125504744 creator A5054617879 @default.
• W3125504744 creator A5068771083 @default.
• W3125504744 creator A5069935336 @default.
• W3125504744 date "2021-01-19" @default.
• W3125504744 modified "2023-10-03" @default.
• W3125504744 title "Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects" @default.
• W3125504744 cites W1480235891 @default.
• W3125504744 cites W1592062002 @default.
• W3125504744 cites W1638584560 @default.
• W3125504744 cites W1750690213 @default.
• W3125504744 cites W1966332737 @default.
• W3125504744 cites W1967006697 @default.
• W3125504744 cites W1967876659 @default.
• W3125504744 cites W1969729473 @default.
• W3125504744 cites W1976539175 @default.
• W3125504744 cites W1977348409 @default.
• W3125504744 cites W1977574452 @default.
• W3125504744 cites W1980021465 @default.
• W3125504744 cites W1985368964 @default.
• W3125504744 cites W1989740856 @default.
• W3125504744 cites W1995890978 @default.
• W3125504744 cites W1998785898 @default.
• W3125504744 cites W2000732112 @default.
• W3125504744 cites W2003067838 @default.
• W3125504744 cites W2003957081 @default.
• W3125504744 cites W2005118820 @default.
• W3125504744 cites W2006242918 @default.
• W3125504744 cites W2017857953 @default.
• W3125504744 cites W2020716000 @default.
• W3125504744 cites W2027146935 @default.
• W3125504744 cites W2052791725 @default.
• W3125504744 cites W2056538157 @default.
• W3125504744 cites W2064926408 @default.
• W3125504744 cites W2066472053 @default.
• W3125504744 cites W2067266295 @default.
• W3125504744 cites W2067962779 @default.
• W3125504744 cites W2071456480 @default.
• W3125504744 cites W2072302129 @default.
• W3125504744 cites W2080883259 @default.
• W3125504744 cites W2100565760 @default.
• W3125504744 cites W2115932664 @default.
• W3125504744 cites W2153351158 @default.
• W3125504744 cites W2155060586 @default.
• W3125504744 cites W2240649179 @default.
• W3125504744 cites W2312754984 @default.
• W3125504744 cites W2328656558 @default.
• W3125504744 cites W2330666918 @default.
• W3125504744 cites W2330718573 @default.
• W3125504744 cites W2502617434 @default.
• W3125504744 cites W2520903395 @default.
• W3125504744 cites W2524803401 @default.
• W3125504744 cites W2600053143 @default.
• W3125504744 cites W2694095774 @default.
• W3125504744 cites W2737070457 @default.
• W3125504744 cites W2746806160 @default.
• W3125504744 cites W2747066494 @default.
• W3125504744 cites W2768440581 @default.
• W3125504744 cites W2785611327 @default.
• W3125504744 cites W2802985983 @default.
• W3125504744 cites W2806510721 @default.
• W3125504744 cites W2807146497 @default.
• W3125504744 cites W2884658410 @default.
• W3125504744 cites W2885520602 @default.
• W3125504744 cites W2890036883 @default.
• W3125504744 cites W2908752416 @default.
• W3125504744 cites W2917570553 @default.
• W3125504744 cites W2964240146 @default.
• W3125504744 cites W2971235488 @default.
• W3125504744 cites W2981578609 @default.
• W3125504744 cites W2982701129 @default.
• W3125504744 cites W2995926412 @default.
• W3125504744 cites W3004604014 @default.
• W3125504744 cites W3014892080 @default.
• W3125504744 cites W3037172782 @default.
• W3125504744 cites W3087544605 @default.
• W3125504744 cites W4237251389 @default.
• W3125504744 doi "https://doi.org/10.3390/ijms22020961" @default.
• W3125504744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7835830" @default.
• W3125504744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33478045" @default.
• W3125504744 hasPublicationYear "2021" @default.
• W3125504744 type Work @default.
• W3125504744 sameAs 3125504744 @default.
• W3125504744 citedByCount "14" @default.
• W3125504744 countsByYear W31255047442021 @default.
• W3125504744 countsByYear W31255047442022 @default.
• W3125504744 countsByYear W31255047442023 @default.
• W3125504744 crossrefType "journal-article" @default.
• W3125504744 hasAuthorship W3125504744A5054617879 @default.
• W3125504744 hasAuthorship W3125504744A5068771083 @default.
• W3125504744 hasAuthorship W3125504744A5069935336 @default.
• W3125504744 hasBestOaLocation W31255047441 @default.
• W3125504744 hasConcept C147789679 @default.
• W3125504744 hasConcept C155647269 @default.
• W3125504744 hasConcept C17525397 @default.
• W3125504744 hasConcept C178790620 @default.
• W3125504744 hasConcept C179104552 @default.

• next