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- W3125543389 abstract "Background: Irritable bowel syndrome (IBS) is a common functional bowel disorder. The global incidence of IBS is as high as 9% to 23%, accounting for about 50% of outpatients in gastroenterology, and the new case detection rate is 0.2% every year. IBS has become a global gastrointestinal functional disease. Although IBS is not a life-threatening disease, it seriously affects the quality of life of patients, causing huge economic and mental burden to individuals, society and families. Lipi Guben decoction (LPGBD) is an important auxiliary treatment for IBS, but lack of robust Evidence-based medicine evidence proving its efficacy. Therefore, we designed a randomized controlled trial to evaluate the efficacy and safety of LPGBD in the treatment of IBS. Methods: In this randomized controlled trial, a total of 100 eligible patients will be allocated to the blank control group or LPGBD group in a ratio of 1:1. The treatment period was 12 weeks. The primary outcome measure will be the total clinical effective rate. The Secondary outcomes will include IBS clinical symptom scores, IBS-Severity Scoring System, IBS-Quality of life, Hamilton Rating Scale for Anxiety, Hamilton Rating Scale for Depression, and Bristol Stool Form Scale. The safety outcome will include Echocardiogram, blood examination (including blood routine test, liver function test, and renal function test), urine routine test and stool routine test. The evaluation indicators and all safety results will be performed at baseline, week 4, week 8 and week 12. Results: This study will be helpful to evaluate the efficacy and safety of LPGBD in the treatment of IBS. Conclusion: LPGBD may improve the clinical efficacy of patients with IBS, which has important value in practical application Trial registration: Chictr20000039617, registration time: November 3, 2020" @default.
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- W3125543389 date "2021-01-22" @default.
- W3125543389 modified "2023-09-29" @default.
- W3125543389 title "Lipi Guben decoction in treating diarrheal irritable bowel syndrome" @default.
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- W3125543389 doi "https://doi.org/10.1097/md.0000000000023887" @default.
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