Matches in SemOpenAlex for { <https://semopenalex.org/work/W3125580979> ?p ?o ?g. }
- W3125580979 abstract "Genome-wide association studies have identified many susceptibility genes for adolescent idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi-ethnic populations. LBX1 is the most promising candidate gene in the etiology of AIS. We aimed to appraise the literature for the association of LBX1 gene polymorphisms with susceptibility and curve progression in AIS. We also reviewed the function of the LBX1 gene in muscle progenitor cell migration and neuronal determination processes. Three susceptibility loci (rs11190870, rs625039, and rs11598564) near the LBX1 gene, as well as another susceptibility locus (rs678741), related to LBX1 regulation, have been successfully verified to have robust associations with AIS in multi-ethnic populations. The LBX1 gene plays an essential role in regulating the migration and proliferation of muscle precursor cells, and it is known to play a role in neuronal determination processes, especially for the fate of somatosensory relay neurons. The LBX1 gene is the most promising candidate gene in AIS susceptibility due to its position and possible functions in muscle progenitor cell migration and neuronal determination processes. The causality between susceptibility loci related to the LBX1 gene and the pathogenesis of AIS deserves to be explored with further integrated genome-wide and epigenome-wide association studies." @default.
- W3125580979 created "2021-02-01" @default.
- W3125580979 creator A5024380956 @default.
- W3125580979 creator A5029573546 @default.
- W3125580979 creator A5030181618 @default.
- W3125580979 creator A5039921012 @default.
- W3125580979 date "2021-01-18" @default.
- W3125580979 modified "2023-10-15" @default.
- W3125580979 title "The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis" @default.
- W3125580979 cites W1569416402 @default.
- W3125580979 cites W1572304090 @default.
- W3125580979 cites W1756743071 @default.
- W3125580979 cites W1837678638 @default.
- W3125580979 cites W1944377017 @default.
- W3125580979 cites W1967823832 @default.
- W3125580979 cites W1968235561 @default.
- W3125580979 cites W1971322258 @default.
- W3125580979 cites W1971401852 @default.
- W3125580979 cites W1975012076 @default.
- W3125580979 cites W1981970128 @default.
- W3125580979 cites W1982700114 @default.
- W3125580979 cites W1983265548 @default.
- W3125580979 cites W1986744707 @default.
- W3125580979 cites W1987164970 @default.
- W3125580979 cites W2000207589 @default.
- W3125580979 cites W2006112035 @default.
- W3125580979 cites W2006242332 @default.
- W3125580979 cites W2017664227 @default.
- W3125580979 cites W2021847617 @default.
- W3125580979 cites W2034947480 @default.
- W3125580979 cites W2035745568 @default.
- W3125580979 cites W2037727766 @default.
- W3125580979 cites W2071913782 @default.
- W3125580979 cites W2075676427 @default.
- W3125580979 cites W2076186219 @default.
- W3125580979 cites W2078044808 @default.
- W3125580979 cites W2082785396 @default.
- W3125580979 cites W2083300897 @default.
- W3125580979 cites W2098106877 @default.
- W3125580979 cites W2102629679 @default.
- W3125580979 cites W2128717994 @default.
- W3125580979 cites W2133901861 @default.
- W3125580979 cites W2138144988 @default.
- W3125580979 cites W2139909837 @default.
- W3125580979 cites W2155235043 @default.
- W3125580979 cites W2164389373 @default.
- W3125580979 cites W2164445038 @default.
- W3125580979 cites W2180503594 @default.
- W3125580979 cites W2268086000 @default.
- W3125580979 cites W2293098022 @default.
- W3125580979 cites W2321001766 @default.
- W3125580979 cites W2329008527 @default.
- W3125580979 cites W2333697267 @default.
- W3125580979 cites W2334146711 @default.
- W3125580979 cites W2366031580 @default.
- W3125580979 cites W2467085013 @default.
- W3125580979 cites W2477632658 @default.
- W3125580979 cites W2549220949 @default.
- W3125580979 cites W2551701966 @default.
- W3125580979 cites W2586734287 @default.
- W3125580979 cites W2592748303 @default.
- W3125580979 cites W2622416943 @default.
- W3125580979 cites W2743337585 @default.
- W3125580979 cites W2746520029 @default.
- W3125580979 cites W2749414791 @default.
- W3125580979 cites W2756400317 @default.
- W3125580979 cites W2757747178 @default.
- W3125580979 cites W2760408890 @default.
- W3125580979 cites W2809231138 @default.
- W3125580979 cites W2883781053 @default.
- W3125580979 cites W2888158408 @default.
- W3125580979 cites W2891785068 @default.
- W3125580979 cites W2892401655 @default.
- W3125580979 cites W2895170936 @default.
- W3125580979 cites W2895778205 @default.
- W3125580979 cites W2896808142 @default.
- W3125580979 cites W2903475674 @default.
- W3125580979 cites W2946421931 @default.
- W3125580979 cites W2961661954 @default.
- W3125580979 cites W2967394846 @default.
- W3125580979 cites W2982161088 @default.
- W3125580979 cites W2994364867 @default.
- W3125580979 cites W2994939556 @default.
- W3125580979 cites W3005697102 @default.
- W3125580979 cites W3035950360 @default.
- W3125580979 cites W80641945 @default.
- W3125580979 doi "https://doi.org/10.3389/fgene.2020.614984" @default.
- W3125580979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7848184" @default.
- W3125580979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33537061" @default.
- W3125580979 hasPublicationYear "2021" @default.
- W3125580979 type Work @default.
- W3125580979 sameAs 3125580979 @default.
- W3125580979 citedByCount "5" @default.
- W3125580979 countsByYear W31255809792022 @default.
- W3125580979 countsByYear W31255809792023 @default.
- W3125580979 crossrefType "journal-article" @default.
- W3125580979 hasAuthorship W3125580979A5024380956 @default.
- W3125580979 hasAuthorship W3125580979A5029573546 @default.
- W3125580979 hasAuthorship W3125580979A5030181618 @default.
- W3125580979 hasAuthorship W3125580979A5039921012 @default.